Human Papillomavirus in HNSCC: Recognition of a Distinct Disease Type

SEER Cancer Statistics Review, 1975-2003

2006 • 11,387 citations

Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer

2003 • 6,072 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

1995 • 3,371 citations

Classification of papillomaviruses

2004 • 3,098 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers

2000 • 3,004 citations

Human papillomavirus and cervical cancer

2007 • 2,789 citations

Improved Survival of Patients With Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial

2008 • 2,660 citations

Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer

2007 • 2,615 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review

2005 • 2,078 citations

Incidence Trends for Human Papillomavirus–Related and –Unrelated Oral Squamous Cell Carcinomas in the United States

2008 • 1,522 citations

Distinct Risk Factor Profiles for Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck Cancers

2008 • 1,492 citations

Human Papillomavirus and Oral Cancer: The International Agency for Research on Cancer Multicenter Study

2003 • 1,212 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Mechanisms of Human Papillomavirus-Induced Oncogenesis

2004 • 1,002 citations

Human Papillomavirus Infection as a Risk Factor for Squamous-Cell Carcinoma of the Head and Neck

2001 • 931 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

1996 • 904 citations

Human Papillomavirus-Associated Cancers in Patients With Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome

2000 • 884 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

Telomerase activation by the E6 gene product of human papillomavirus type 16

1996 • 825 citations

Molecular Classification Identifies a Subset of Human Papillomavirus–Associated Oropharyngeal Cancers With Favorable Prognosis

2006 • 794 citations

Tongue and tonsil carcinoma

2005 • 736 citations

A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen

2007 • 726 citations

Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta‐analysis

2007 • 724 citations

EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal Cancer

2008 • 609 citations

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1991 • 592 citations

Oral Cancer Risk in Relation to Sexual History and Evidence of Human Papillomavirus Infection

1998 • 591 citations

Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells

1995 • 577 citations

Human Papillomavirus Infection Requires Cell Surface Heparan Sulfate

2001 • 553 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

Rapid Clearance of Human Papillomavirus and Implications for Clinical Focus on Persistent Infections

2008 • 505 citations

Human papillomavirus as a risk factor for oral squamous cell carcinoma: A meta-analysis, 1982-1997

2001 • 495 citations

Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers

2003 • 479 citations

HUMAN PAPILLOMAVIRUSES

1994 • 470 citations

Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis

1983 • 463 citations

Systematic Review of Genomic Integration Sites of Human Papillomavirus Genomes in Epithelial Dysplasia and Invasive Cancer of the Female Lower Genital Tract

2004 • 454 citations

Human papillomavirus positive squamous cell carcinoma of the oropharynx

2001 • 450 citations

Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer

2006 • 437 citations

Carcinoma of the cervix and tobacco smoking: Collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies

2005 • 427 citations

The Epidemiology and Risk Factors of Head and Neck Cancer: a Focus on Human Papillomavirus

2007 • 417 citations

Combined analysis of HPV‐DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer

2007 • 415 citations

Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx

2003 • 412 citations

Cystic lymph node metastasis in patients with head and neck cancer: An HPV‐associated phenomenon

2008 • 408 citations

Self-assembly of human papillomavirus type 1 capsids by expression of the L1 protein alone or by coexpression of the L1 and L2 capsid proteins

1993 • 400 citations

Immune evasion in human papillomavirus-associated cervical cancer

2002 • 395 citations

Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control

2002 • 392 citations

Identification of the alpha6 integrin as a candidate receptor for papillomaviruses

1997 • 384 citations

Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity

2005 • 383 citations

Human papillomavirus and head and neck cancer: a systematic review and meta‐analysis

2006 • 377 citations

Human papillomavirus (HPV) DNA in tonsillar cancer: Clinical correlates, risk of relapse, and survival

2000 • 375 citations

Human papillomavirus (HPV) in head and neck cancer

1997 • 373 citations

Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.

1994 • 370 citations

Chemoselection As a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated With HPV16 Copy Number

2008 • 359 citations

Marked differences in survival rate between smokers and nonsmokers with HPV 16‐associated tonsillar carcinomas

2008 • 348 citations

Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas

2001 • 338 citations

Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein.

1996 • 329 citations

The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes

1993 • 328 citations

Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas

2001 • 309 citations

Human Papillomavirus and head and neck cancer: Epidemiology and molecular biology

1998 • 302 citations

Papillomavirus DNA in human tongue carcinomas

1985 • 301 citations

Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis.

2003 • 298 citations

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1987 • 294 citations

Human papillomavirus type 16 and squamous cell carcinoma of the head and neck.

2002 • 281 citations

Human papillomavirus life cycle: active and latent phases

1999 • 271 citations

Detection of Human Papillomavirus-16 in Fine-Needle Aspirates to Determine Tumor Origin in Patients with Metastatic Squamous Cell Carcinoma of the Head and Neck

2007 • 251 citations

A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16^INK4A and p53 in the absence of mutations in p53 exons 5–8

2003 • 243 citations

Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma

1996 • 241 citations

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties

1990 • 238 citations

Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: A population-based case-control study in southern Sweden

2005 • 237 citations

Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer

2002 • 236 citations

Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil

2003 • 233 citations

Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.

1989 • 227 citations

Inverse Relationship between Human Papillomavirus-16 Infection and Disruptivep53Gene Mutations in Squamous Cell Carcinoma of the Head and Neck

2008 • 225 citations

Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma.

1998 • 221 citations

Inhibition of p53 DNA binding by human papillomavirus E6 proteins

1994 • 214 citations

HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c‐myc during tumor formation

2007 • 214 citations

Immortalization of normal human oral keratinocytes with type 16 human papillomavirus

1991 • 212 citations

A comprehensive natural history model of HPV infection and cervical cancer to estimate the clinical impact of a prophylactic HPV‐16/18 vaccine

2003 • 203 citations

Human papillomaviruses in 91 oral cancers from indian betel quid chewers—high prevalence and multiplicity of infections

1995 • 199 citations

Human papillomavirus and cancers of the upper aerodigestive tract: a review of epidemiological and experimental evidence.

1996 • 194 citations

Transmission of High-Risk Human Papillomavirus (HPV) between Parents and Infant: a Prospective Study of HPV in Families in Finland

2005 • 191 citations

Oral cavity and pharynx cancer incidence rates in the United States, 1975–1998 ☆ ☆Portions of this manuscript were presented at the meeting of the American Association of Public Health Dentistry in October 1999.

2002 • 189 citations

Smoking and human papillomavirus infection: pooled analysis of the International Agency for Research on Cancer HPV Prevalence Surveys

2008 • 181 citations

Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.

1995 • 178 citations

Human papilloma virus and p53 in head and neck cancer: clinical correlates and survival.

1996 • 165 citations

Quantitative Role of the Human Papillomavirus Type 16 E5 Gene during the Productive Stage of the Viral Life Cycle

2003 • 163 citations

Changing patterns of tonsillar squamous cell carcinoma in the United States.

2000 • 160 citations

Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations.

2002 • 157 citations

Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated? Analysis of p53 exons 2-11 and human papillomavirus 16/18 E6 transcripts in 123 unselected tumor specimens.

2003 • 149 citations

Age-dependence of human papillomavirus DNA presence in oral squamous cell carcinomas

1996 • 145 citations

Human papillomavirus DMA in oral squamous cell carcinomas and normal mucosa

1994 • 138 citations

Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking

2007 • 134 citations

Prevalence of mucosotropic human papillomaviruses in squamous-cell carcinomas of the head and neck

1996 • 129 citations

Human Papillomaviruses

1994 • 127 citations

PCR detection of human papillomavirus of the mucosa: comparison between MY09/11 and GP5+/6+ primer sets

2004 • 125 citations

Immune status as a determinant of human papillomavirus detection and its association with anal epithelial abnormalities

1990 • 121 citations

Human papillomavirus type 16 and 18 DNA in oral squamous cell carcinoma and normal mucosa

2003 • 120 citations

Clinical and histologic features of vulvar carcinomas analyzed for human papillomavirus status: Evidence that squamous cell carcinoma of the vulva has more than one etiology

1991 • 120 citations

Interaction of human immunodeficiency and papilloma viruses: Association with anal epithelial abnormality in homosexual men

1990 • 118 citations

Centrosome abnormalities, genomic instability and carcinogenic progression

2001 • 115 citations

Human papillomavirus infection and anal carcinoma. Retrospective analysis by in situ hybridization and the polymerase chain reaction.

1992 • 113 citations

Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil.

1990 • 111 citations

Human Papillomavirus Prevalence and Types in Newborns and Parents

2004 • 111 citations

Prevalence of human papillomavirus types 16 and 18 in squamous‐cell carcinoma of the penis: A retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction

1992 • 109 citations

HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs

2005 • 106 citations

Human Papillomavirus Type 16 E1 ^∧ E4 Contributes to Multiple Facets of the Papillomavirus Life Cycle

2005 • 104 citations

Enhancement of EGF- and PMA-mediated MAP kinase activation in cells expressing the human papillomavirus type 16 E5 protein

1997 • 103 citations

Human papillomaviruses: are we ready to type?

1989 • 99 citations

Reorganization of Nuclear Domain 10 Induced by Papillomavirus Capsid Protein L2

2002 • 98 citations

Role of Rb-Dependent and Rb-Independent Functions of Papillomavirus E7 Oncogene in Head and Neck Cancer

2007 • 98 citations

Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): A natural disease model provides insights into viral carcinogenesis

2005 • 95 citations

Epidermodysplasia verruciformis. Immunological and nonimmunological surveillance mechanisms: Role in tumor progression

1997 • 91 citations

The L2 Minor Capsid Protein of Human Papillomavirus Type 16 Interacts with a Network of Nuclear Import Receptors

2004 • 88 citations

Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV

1997 • 87 citations

High frequency of latent and clinical human papillomavirus cervical infections in immunocompromised human immuno-deficiency virus-infected women

1992 • 86 citations

Modulation of the Cell Division Cycle by Human Papillomavirus Type 18 E4

2002 • 86 citations

High Frequency of Latent and Clinical Human Papillomavirus Cervical Infections in Immunocompromised Human Immunodeficiency Virus-Infected Women

1992 • 86 citations

Molecular analyses and prognostic relevance of HPV in head and neck tumours

2007 • 84 citations

Human Papillomavirus and Risk of Laryngeal Cancer

2000 • 83 citations

Antibodies against oncoproteins E6 and E7 of human papillomavirus types 16 and 18 in patients with head-and-neck squamous-cell carcinoma

2000 • 79 citations

Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation

1997 • 73 citations

Papillomavirus-Like Particles for Serology and Vaccine Development

1996 • 71 citations

Physical state and expression of human papillomavirus in laryngeal carcinoma and surrounding normal mucosa

2000 • 69 citations

Presence of HPV in head and neck tumours: high prevalence in tonsillar localization.

2004 • 68 citations

Human Papillomavirus Infection in the Malignant and Premalignant Head and Neck Epithelium

1995 • 66 citations

Detection and Typing of Human Papillomavirus DNA in Benign and Malignant Tumours of Laryngeal Epithelium

1998 • 50 citations

Papilloma formation by cottontail rabbit papillomavirus requires E1 and E2 regulatory genes in addition to E6 and E7 transforming genes

1994 • 49 citations

A New Link Between Fanconi Anemia and Human Papillomavirus-Associated Malignancies

2003 • 45 citations

Beyond Human Papillomavirus: The Cervix, Exogenous Secondary Factors, and the Development of Cervical Precancer and Cancer

2004 • 44 citations

In situ hybridization detection of single-copy human papillomavirus on isolated cells, using a catalyzed signal amplification system: Genpoint?

2001 • 44 citations

Tissue Effects of and Host Response to Human Papillomavirus Infection

1991 • 42 citations

Absence of Human Papillomavirus in Tonsillar Squamous Cell Carcinomas from Chinese Patients

2003 • 39 citations

Basaloid in contrast to nonbasaloid head and neck squamous cell carcinomas display aberrations especially in cell cycle control genes

2003 • 36 citations

Evaluation of oral and laryngeal specimens for human papillomavirus (HPV) DNA by dot blot hybridization

1990 • 31 citations

Detection of human papillomavirus (HPV) type 47 DNA in malignant lesions from epidermodysplasia verruciformis by protocols for precise typing of related HPV DNAs

1996 • 31 citations

Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: Use of fuzzy neural networks

2005 • 28 citations

Chemo-radiotherapy in head and neck cancer

2006 • 28 citations

Prevalence of human papilloma virus DNA in head and neck cancers carrying wild-type or mutant p53 tumor suppressor genes.

1999 • 20 citations

Taking up Challenges at the Interface of Wear and Tear

2007 • 17 citations

Human papillomavirus subtypes are not uncommon

2007 • 17 citations

The site of infection and ethnicity of the patient influence the biological pathways to HPV-induced mucosal cancer

2004 • 10 citations