Apoptosis, tolerance, and regulatory T cells – old wine, new wineskins

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Consequences of Cell Death

2000 • 1,382 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans

2001 • 865 citations

Infectious immunological tolerance.

1971 • 811 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Control of T‐cell activation by CD4⁺ CD25⁺ suppressor T cells

2001 • 560 citations

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

2000 • 524 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L

1998 • 472 citations

Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages

2000 • 452 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

TGF-β Released by Apoptotic T Cells Contributes to an Immunosuppressive Milieu

2001 • 414 citations

Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10.

1992 • 412 citations

CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance

1996 • 394 citations

CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.

1997 • 375 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

Ultraviolet Radiation-induced Apoptosis Is Mediated by Activation of CD-95 (Fas/APO-1)

1997 • 298 citations

Immunogenicity of Apoptotic Cells In Vivo: Role of Antigen Load, Antigen-Presenting Cells, and Cytokines

1999 • 295 citations

Induction of anterior chamber-associated immune deviation requires an intact, functional spleen.

1981 • 255 citations

Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes.

1996 • 249 citations

Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis

1998 • 220 citations

Pretransplantation Blood Transfusion Revisited

1991 • 220 citations

T Cell Death and Transplantation Tolerance

2001 • 218 citations

Cross-tolerance: A Pathway for Inducing Tolerance to Peripheral Tissue Antigens

1998 • 216 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness

2002 • 193 citations

A vision of cell death: insights into immune privilege

1997 • 177 citations

Role of Antigen-Presenting Cells in Mediating Tolerance and Autoimmunity

1999 • 155 citations

Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID.

1991 • 144 citations

T cell vaccination induces T cell receptor Vβ-specific Qa-1-restricted regulatory CD8⁺T cells

1998 • 140 citations

Suppressive Mechanisms Involving Sensitization and Tolerance in Contact Allergy

1980 • 135 citations

Dual Immunological Unresponsiveness Induced by Cell Membrane Coupled Hapten or Antigen*

1966 • 108 citations

Split tolerance of T_hl and T_h2 cells in tolerance to Theiler's murine encephalomyelitis virus

1993 • 107 citations

TRAIL: A Mechanism of Tumor Surveillance in an Immune Privileged Site

2002 • 104 citations

Intermediary role of macrophages in the passage of suppressor signals between T-cell subsets.

1978 • 92 citations

A Splenic Requirement for the Generation of Suppressor T Cells

1977 • 84 citations

The role of T cell apoptosis in transplantation tolerance

2000 • 83 citations

Cutting Edge: Inflammatory Signals Drive Organ-Specific Autoimmunity to Normally Cross-Tolerizing Endogenous Antigen

2002 • 75 citations

Fas-FasL Interaction Involved in Pathogenesis of Ocular Toxoplasmosis in Mice

1999 • 72 citations

Studies on Hapten Specific T Cell Immunity and Suppression

1980 • 66 citations

Die Entwickelung der in fremden Grund versetzten lebenden Gewebe

1873 • 62 citations

A burn induced Ly-2 suppressor T cell lowers resistance to bacterial infection

1985 • 44 citations

Induction of a type 1 regulatory CD4 T cell response following Vβ8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis

2001 • 35 citations

Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion

2002 • 32 citations

Ipr T cells vaccinate against lupus in MRL/lpr mice

1992 • 30 citations

Suppressor cells in tolerance to contact sensitivity active against hapten-syngeneic and hapten-allogeneic determinants.

1977 • 28 citations

HindIII Liposomes Suppress Delayed-Type Hypersensitivity Responses In Vivo and Induce Epidermal IL-10 In Vitro

1998 • 21 citations

Resident tissue macrophages within the normal rat iris lack immunosuppressive activity and are effective antigen-presenting cells

2000 • 18 citations

Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis

2001 • 16 citations

Resident tissue macrophages within the normal rat iris lack immunosuppressive activity and are effective antigen-presenting cells

2000 • 16 citations