Links Among Growth Factors, Hormones, and Nuclear Factors With Essential Roles in Bone Formation

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

1997 • 2,784 citations

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

1999 • 2,238 citations

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

1997 • 1,463 citations

Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors

1998 • 799 citations

The Role of C/EBP Genes in Adipocyte Differentiation

1998 • 736 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis

1993 • 677 citations

The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions

1998 • 661 citations

Estrogen Stimulates Gene Expression and Protein Production of Osteoprotegerin in Human Osteoblastic Cells*

1999 • 657 citations

Transcriptional Roles of Nuclear Factor κB and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor α-Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells

1995 • 657 citations

Mutations in TWIST, a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome

1997 • 657 citations

Bone Morphogenetic Protein and Bone Morphogenetic Protein Gene Family in Bone Formation and Repair

1998 • 628 citations

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

1993 • 621 citations

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

1987 • 619 citations

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1997 • 606 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

A MODEL FOR DEVELOPMENT AND EVOLUTION OF COMPLEX MORPHOLOGICAL STRUCTURES

1991 • 589 citations

Molecular Cloning and Characterization of PEBP2β, the Heterodimeric Partner of a Novel Drosophila runt-Related DNA Binding Protein PEBP2α

1993 • 504 citations

Local and Systemic Factors in the Pathogenesis of Osteoporosis

1988 • 496 citations

Fibroblast Growth Factors as Multifunctional Signaling Factors

1998 • 489 citations

Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex

1997 • 441 citations

Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functionsProceedings of Xth International Congress on Hormonal Steroids, Quebec, Canada, 17–21 June 1998.

1999 • 408 citations

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

1994 • 403 citations

CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter

1996 • 399 citations

A Phase I/II Clinical Trial to Evaluate a Combination of Recombinant Human Platelet‐Derived Growth Factor‐BB and Recombinant Human Insulin‐Like Growth Factor‐I in Patients with Periodontal Disease

1997 • 396 citations

The t(8;21) Fusion Protein Interferes with AML-1B-Dependent Transcriptional Activation

1995 • 391 citations

Transcriptional cross-talk, the second mode of steroid hormone receptor action

1998 • 390 citations

Estradiol Effects on Proliferation, Messenger Ribonucleic Acid for Collagen and Insulin-like Growth Factor-I, and Parathyroid Hormone-Stimulated Adenylate Cyclase Activity in Osteoblastic Cells from Calvariae and Long Bones

1989 • 369 citations

Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1989 • 337 citations

The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages.

1995 • 333 citations

A UK Consensus Group on management of glucocorticoid‐induced osteoporosis: an update

1998 • 325 citations

Role of cytokines in bone resorption

1995 • 315 citations

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

1997 • 282 citations

Alternative splicing and genomic structure of theAML1gene involved in acute myeloid leukemia

1995 • 269 citations

Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning

1996 • 259 citations

Two Domains Unique to Osteoblast-Specific Transcription Factor Osf2/Cbfa1 Contribute to Its Transactivation Function and Its Inability To Heterodimerize with Cbfβ

1998 • 253 citations

The Tissue-Specific Nuclear Matrix Protein, NMP-2, Is a Member of the AML/PEBP2/Runt Domain Transcription Factor Family: Interactions with the Osteocalcin Gene Promoter

1995 • 245 citations

The Actions and Interactions of Sex Steroids and Growth Factors/Cytokines on the Skeleton

1999 • 245 citations

C/EBP, c-Myb, and PU.1 Cooperate To Regulate the Neutrophil Elastase Promoter

1996 • 240 citations

The C/EBP Family of Transcription Factors

1995 • 236 citations

Osteoprogenitor cell frequency in rat bone marrow stromal populations: Role for heterotypic cell-cell interactions in osteoblast differentiation

1999 • 226 citations

THE SCIENCE AND THERAPY OF GLUCOCORTICOID-INDUCED BONE LOSS

1998 • 208 citations

PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.

1994 • 204 citations

Cortisol Inhibits the Synthesis of Insulin-Like Growth Factor-I in Skeletal Cells*

1990 • 201 citations

Human Platelet-Derived Transforming Growth Factor-βStimulates Parameters of Bone Growth in Fetal Rat Calvariae*

1986 • 198 citations

The in vivo anabolic actions of prostaglandins in bone

1997 • 197 citations

Prostaglandin E₂Stimulates Insulin-Like Growth Factor I Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1991 • 197 citations

Growth factor stimulation of bone healing

1998 • 193 citations

CREB Controls LAP/C/EBPβ Transcription

1997 • 189 citations

Expression of Bone Morphogenetic Proteins in Fracture Healing

1998 • 183 citations

Fibroblast growth factor receptors: lessons from the genes

1998 • 175 citations

The Potential Role of Chemokines and Inflammatory Cytokines in Periodontal Disease Progression

1999 • 174 citations

An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene.

1996 • 171 citations

A PEBP2α/AML-1-related Factor Increases Osteocalcin Promoter Activity through Its Binding to an Osteoblast-specific cis-Acting Element

1995 • 171 citations

The Basic Domain of Myogenic Basic Helix-Loop-Helix (bHLH) Proteins Is the Novel Target for Direct Inhibition by Another bHLH Protein, Twist

1997 • 164 citations

Interleukin-6-Specific Activation of the C/EBPδ Gene in Hepatocytes Is Mediated by Stat3 and Sp1

1998 • 163 citations

Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone.

1991 • 163 citations

Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae.

1985 • 161 citations

Reduction in Transforming Growth Factor β Receptor I Expression and Transcription Factor CBFa1 on Bone Cells by Glucocorticoid

1998 • 160 citations

Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton

1996 • 154 citations

Tamoxifen and estrogen lower circulating lipoprotein(a) concentrations in healthy postmenopausal women.

1994 • 152 citations

Effects of Fibroblast Growth Factors on Deoxyribonucleic Acid and Collagen Synthesis in Rat Parietal Bone Cells*

1989 • 148 citations

Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures.

1990 • 147 citations

Roles of CCAAT/Enhancer-binding Proteins in Regulation of Liver Regenerative Growth

1998 • 145 citations

Estradiol Regulation of Insulin-Like Growth Factor-I Expression in Osteoblastic Cells: Evidence for Transcriptional Control

1991 • 138 citations

Independent Changes in Type I and Type II Receptors for Transforming Growth Factor β Induced by Bone Morphogenetic Protein 2 Parallel Expression of the Osteoblast Phenotype

1995 • 132 citations

Role of Nitric Oxide and Prostaglandins in Mechanically Induced Bone Formation

1998 • 125 citations

Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding sites in interleukin-6 promoter inhibition by estrogens.

1996 • 112 citations

Defective bone formation in Krox-20 mutant mice

1996 • 108 citations

Transforming growth factor-β1: Induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7)

1998 • 105 citations

Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3

1994 • 105 citations

Core Binding Factor Cannot Synergistically Activate the Myeloperoxidase Proximal Enhancer in Immature Myeloid Cells without c-Myb

1997 • 98 citations

Is Parathyroid Hormone a Therapeutic Option for Osteoporosis? A Review of the Clinical Evidence

1998 • 92 citations

Mechanism of action of estrogen on cancellous bone balance in tibiae of ovariectomized growing rats: Inhibition of indices of formation and resorption

1993 • 92 citations

Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activity.

1992 • 90 citations

CBFa(AML/PEBP2)-related elements in the TGF-β type I receptor promoter and expression with osteoblast differentiation

1998 • 90 citations

Bone and Cytokines: Beyond IL-1, IL-6 and TNF-α

1999 • 88 citations

Physiologic and Pathologic Roles of Prostaglandins and Other Eicosanoids in Bone Metabolism

1995 • 87 citations

C/EBP and the Control of Phosphoenolpyruvate Carboxykinase Gene Transcription in the Liver

1998 • 87 citations

Identification of the cAMP Response Element That Controls Transcriptional Activation of the Insulin-like Growth Factor-I Gene by Prostaglandin E2 in Osteoblasts

1996 • 84 citations

An estrogen receptor basis for raloxifene action in boneProceedings of Xth International Congress on Hormonal Steroids, Quebec, Canada, 17–21 June 1998.

1999 • 83 citations

Mice, Estrogen, and Postmenopausal Osteoporosis

1999 • 82 citations

17β-Estradiol Potently Suppresses cAMP-induced Insulin-like Growth Factor-I Gene Activation in Primary Rat Osteoblast Cultures

1997 • 77 citations

CCAAT/Enhancer-binding Protein δ Activates Insulin-like Growth Factor-I Gene Transcription in Osteoblasts

1997 • 75 citations

Multiple and Essential Sp1 Binding Sites in the Promoter for Transforming Growth Factor-β Type I Receptor

1997 • 73 citations

Role of platelet derived growth factor in bone cell function.

1992 • 71 citations

Characterization of the Primary σ Factor of Staphylococcus aureus

1996 • 67 citations

Regulation of insulin-like growth factor I transcription by cyclic adenosine 3',5'-monophosphate (cAMP) in fetal rat bone cells through an element within exon 1: protein kinase A-dependent control without a consensus AMP response element.

1995 • 67 citations

Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.

1992 • 64 citations

CCAAT/Enhancer-binding Protein δ Is a Critical Regulator of Insulin-like Growth Factor-I Gene Transcription in Osteoblasts

1999 • 58 citations

Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4.

1996 • 56 citations

Cytokine networks in destructive periodontal disease

1995 • 55 citations

Time- and Dose-Related Interactions between Glucocorticoid and Cyclic Adenosine 3′,5′-Monophosphate on CCAAT/Enhancer-Binding Protein-Dependent Insulin-Like Growth Factor I Expression by Osteoblasts1

2000 • 53 citations

CCAAT/Enhancer-Binding Protein Gene Expression Is Mediated by APRF/STAT3

1997 • 52 citations

Interleukin-1 in Combination with Transforming Growth Factor-α Produces Enhanced Bone Resorptionin Vitro*

1988 • 47 citations

Effects of transforming growth factor-beta and IL-1 alpha on prostaglandin synthesis in serum-deprived osteoblastic cells.

1991 • 42 citations

Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats

1993 • 33 citations

Effects of tamoxifen on GH and IGF-I levels in acromegaly

1997 • 33 citations

Regulation of the Growth Hormone-Insulin-Like Growth Factor I Axis in Developing and Adult Monkeys Is Affected by Estradiol Replacement and Supplementation with Insulin-Like Growth Factor I¹

1998 • 30 citations

Prostaglandin E2 restores cancellous bone to immobilized limb and adds bone to overloaded limb in right hindlimb immobilization rats

1993 • 29 citations

Modulation of the Effects of Glucocorticoids on Collagen Synthesis in Fetal Rat Calvariae by Insulin-like Growth Factor Binding Protein-2

1997 • 29 citations

Effect of acute and chronic administration of tamoxifen on GH response to GHRH and on IGF-I serum levels in women with breast cancer

1998 • 29 citations

CCAAT/Enhancer-Binding Protein δ Gene Expression Is Mediated by Autoregulation through Downstream Binding Sites

1998 • 28 citations

Estrogen modulates the mRNA levels for cancellous bone protein of ovariectomized rats

1993 • 28 citations

Cloning, characterization, and expression of the transforming growth factor-beta type I receptor promoter in fetal rat bone cells.

1996 • 27 citations

Cloning, characterization, and expression of the transforming growth factor-β type I receptor promoter in fetal rat bone cells

1996 • 26 citations

Pro-inflammatory cytokines downregulate platelet derived growth factor-α receptor gene expression in human osteoblastic cells

1996 • 25 citations

Growth factors and bone regeneration. Implications of barrier membranes.

1998 • 22 citations

The prevention or treatment of age‐related osteoporosis in the elderly by systemic recombinant growth factor therapy (rhIGF‐I or rhTGFβ): a perspective

1997 • 21 citations

Parathyroid Hormone and Parathyroid Hormone-Related Protein: Model Systems for the Development of an Osteoporosis Therapy

1999 • 21 citations

The biology of the cytokine sequence cascade.

1996 • 21 citations

Regulation of IGF Activity in Bone

1994 • 19 citations

Repair of nasal defects using collagen gels containing insulin-like growth factor 1

1998 • 17 citations

Steroid receptors at the nexus of transcriptional regulation

1998 • 13 citations

The Role of Prostaglandins and Nitric Oxide in the Response of Bone to Mechanical Stimulation

1997 • 12 citations