17β-Estradiol Potently Suppresses cAMP-induced Insulin-like Growth Factor-I Gene Activation in Primary Rat Osteoblast Cultures

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 1,836 citations

The ovariectomized rat model of postmenopausal bone loss

1991 • 1,345 citations

An interleukin 1 like factor stimulates bone resorption in vitro

1983 • 1,017 citations

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.

1994 • 738 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.

1992 • 685 citations

Parathyroid Hormone Stimulates the Bone Apposition Rate Independently of Its Resorptive Action: Differential Effects of Intermittent and Continuous Administration*

1982 • 620 citations

Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication*

1988 • 606 citations

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

1989 • 541 citations

A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

1988 • 485 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

1993 • 442 citations

Regulatory Effects of Insulin-Like Growth Factors I and II on Bone Collagen Synthesis in Rat Calvarial Cultures*

1989 • 436 citations

Menopausal changes in bone remodeling.

1978 • 436 citations

Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer.

1994 • 390 citations

Estradiol Effects on Proliferation, Messenger Ribonucleic Acid for Collagen and Insulin-like Growth Factor-I, and Parathyroid Hormone-Stimulated Adenylate Cyclase Activity in Osteoblastic Cells from Calvariae and Long Bones

1989 • 369 citations

Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1,25-dihydroxyvitamin D

1986 • 351 citations

Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1989 • 337 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

1993 • 315 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Primer on the metabolic bone diseases and disorders of mineral metabolism.

1997 • 303 citations

[8] Gel retardation

1991 • 295 citations

Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats.

1993 • 276 citations

Bone loss and biochemical indices of bone remodeling in surgically induced postmenopausal women

1987 • 266 citations

Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism.

1981 • 260 citations

Prostaglandin E2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats

1990 • 256 citations

Differential Effects of Estrogen and Growth Hormone on Uterine and Hepatic Insulin-Like Growth Factor I Gene Expression in the Ovariectomized Hypophysectomized Rat*

1988 • 236 citations

Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats.

1994 • 234 citations

Further biochemical and molecular characterization of primary rat parietal bone cell cultures

1988 • 203 citations

Prostaglandin E₂Stimulates Insulin-Like Growth Factor I Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1991 • 197 citations

Local Injections of Human or Rat Growth Hormone or of Purified Human Somatomedin-C Stimulate Unilateral Tibial Epiphyseal Growth in Hypophysectomized Rats*

1985 • 170 citations

Skeletal response of ovariectomized rats to low and high doses of 17β-estradiol

1991 • 156 citations

Tamoxifen and estrogen lower circulating lipoprotein(a) concentrations in healthy postmenopausal women.

1994 • 152 citations

Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function.

1995 • 149 citations

Temporal changes in cancellous bone structure of rats immediately after ovariectomy

1995 • 148 citations

Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures.

1990 • 147 citations

Estradiol Regulation of Insulin-Like Growth Factor-I Expression in Osteoblastic Cells: Evidence for Transcriptional Control

1991 • 138 citations

Functional Analysis of the Rat Insulin-Like Growth Factor I Gene and Identification of an IGF-I Gene Promoter

1992 • 135 citations

Independent Changes in Type I and Type II Receptors for Transforming Growth Factor β Induced by Bone Morphogenetic Protein 2 Parallel Expression of the Osteoblast Phenotype

1995 • 132 citations

Gel electrophoresis assays for DNA-protein interactions.

1989 • 117 citations

Recombinant human insulin-like growth factor: testing the somatomedin hypothesis in hypophysectomized rats

1987 • 115 citations

Benefit of systemically administered rhIGF-I and rhIGF-I/IGFBP-3 on cancellous bone in ovariectomized rats

1994 • 115 citations

Insulin-Like Growth Factor I Regulates Type I Procollagen Messenger Ribonucleic Acid Steady State Levels in Bone of Rats*

1989 • 105 citations

Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3

1994 • 105 citations

Regulation of somatic growth and the somatotropic axis by gonadal steroids: primary effect on insulin-like growth factor I gene expression and secretion.

1996 • 101 citations

Effects of combined and separate intermittent administration of low-dose human parathyroid hormone fragment (1?34) and 17?-estradiol on bone histomorphometry in ovariectomized rats with established osteopenia

1992 • 96 citations

Mechanism of action of estrogen on cancellous bone balance in tibiae of ovariectomized growing rats: Inhibition of indices of formation and resorption

1993 • 92 citations

Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activity.

1992 • 90 citations

Identification of the cAMP Response Element That Controls Transcriptional Activation of the Insulin-like Growth Factor-I Gene by Prostaglandin E2 in Osteoblasts

1996 • 84 citations

Osteoclast formation together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-I

1992 • 79 citations

Parathyroid Hormone-Related Protein Modulates the Effect of Transforming Growth Factor-β on Deoxyribonucleic Acid and Collagen Synthesis in Fetal Rat Bone Cells*

1989 • 78 citations

Regulation of insulin-like growth factor I transcription by cyclic adenosine 3',5'-monophosphate (cAMP) in fetal rat bone cells through an element within exon 1: protein kinase A-dependent control without a consensus AMP response element.

1995 • 67 citations

Effect of oestrogen replacement on bone metabolism and cytokines in surgical menopause

1995 • 65 citations

Prostaglandin E2 rapidly stimulates insulin-like growth factor-I gene expression in primary rat osteoblast cultures: evidence for transcriptional control.

1993 • 54 citations

Estrogen replacement may be an alternative to parathyroid surgery for the treatment of osteoporosis in elderly postmenopausal women presenting with primary hyperparathyroidism: A preliminary report

1996 • 51 citations

Prostaglandin E2 prevents disuse-induced cortical bone loss

1992 • 44 citations

Estrogen blocks parathyroid hormone (PTH)-stimulated osteoclast-like cell formation by selectively affecting PTH-responsive cyclic adenosine monophosphate pathway.

1996 • 44 citations

The effect of systemically administered rhIGF-I/IGFBP-3 complex on cortical bone strength and structure in ovariectomized rats

1995 • 42 citations

Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats

1993 • 33 citations

Estrogen modulates the mRNA levels for cancellous bone protein of ovariectomized rats

1993 • 28 citations

Changes in Bone Morphogenetic Protein Sensitivity Relative to Differentiation in Fetal Rat Bone Cell Cultures

1996 • 27 citations

Effect of estrogen status on bone regulating hormones

1996 • 24 citations

Lack of effect of ovariectomy on divalent cation regulation of skeletal adenylate cyclase

1992 • 3 citations