The Role of Prostaglandins and Nitric Oxide in the Response of Bone to Mechanical Stimulation

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Regulation of bone formation by applied dynamic loads.

1984 • 1,533 citations

Dynamic strain similarity in vertebrates; an alternative to allometric limb bone scaling

1984 • 410 citations

Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo

1996 • 364 citations

Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo

1989 • 357 citations

Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling?

1995 • 332 citations

Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periostal pressure

1994 • 266 citations

A noninvasive, in vivo model for studying strain adaptive bone modeling

1991 • 241 citations

Mechanical loading stimulates rapid changes in periosteal gene expression

1994 • 216 citations

Cellular responses to mechanical loading in vitro

1990 • 202 citations

Prostaglandin E₂Stimulates Insulin-Like Growth Factor I Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1991 • 197 citations

Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation

1995 • 191 citations

The role of prostaglandins in bone in vivo

1990 • 189 citations

Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons

1984 • 184 citations

Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats

1996 • 178 citations

Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation

1996 • 178 citations

The influence of function on the development of bone curvature. An experimental study on the rat tibia

1980 • 177 citations

Expression and functional role of nitric oxide synthase in osteoblast-like cells

1995 • 177 citations

Indomethacin modulation of load-related stimulation of new bone formationin vivo

1989 • 151 citations

Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation

1994 • 144 citations

Osteocytic expression of mRNA for c-fos and IGF-I: an immediate early gene response to an osteogenic stimulus

1996 • 137 citations

Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae

1993 • 120 citations

Stimulation of bone nodule formation in vitro by prostaglandins E1 and E2.

1992 • 102 citations

Stimulation of bone nodule formation in vitro by prostaglandins E1 and E2

1992 • 35 citations