Nitric Oxide in the Kidney: Synthesis, Localization, and Function

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

1991 • 1,872 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Nitric Oxide: First in a New Class of Neurotransmitters

1992 • 1,001 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

1991 • 982 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle

1990 • 854 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.

1992 • 798 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.

1992 • 740 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Intracellular cyclic GMP receptor proteins

1993 • 655 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

1992 • 622 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 • 599 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Nitrate Synthesis in the Germfree and Conventional Rat

1981 • 551 citations

Nitric oxide synthase in macula densa regulates glomerular capillary pressure.

1992 • 531 citations

Inhibition of nitric oxide synthesis by methylene blue

1993 • 519 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Isoforms of nitric oxide synthase

1995 • 482 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.

1991 • 450 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative

1993 • 428 citations

Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat.

1990 • 421 citations

Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.

1993 • 411 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells

1994 • 320 citations

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

1993 • 319 citations

Expression of nitric oxide synthase in kidney macula densa cells

1992 • 296 citations

Endothelial derived relaxing factor controls renal hemodynamics in the normal rat kidney.

1990 • 294 citations

Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells

1993 • 293 citations

Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys.

1991 • 289 citations

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

1990 • 288 citations

Effects of NG-nitro-L-arginine methyl ester on renal function and blood pressure

1991 • 286 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man.

1988 • 267 citations

Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle.

1992 • 257 citations

Role of endothelium-derived relaxing factor in regulation of renal hemodynamic responses

1990 • 250 citations

Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat.

1992 • 248 citations

Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments.

1992 • 247 citations

Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips.

1982 • 228 citations

Role of EDRF (nitric oxide) in diabetic renal hyperfiltration

1993 • 211 citations

Modulation of angiotensin II-induced vasoconstriction by endothelium-derived relaxing factor in the isolated microperfused rabbit afferent arteriole.

1991 • 211 citations

Ca2+/calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase.

1992 • 210 citations

Role of nitric oxide in renal papillary blood flow and sodium excretion.

1992 • 210 citations

Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.

1977 • 209 citations

Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition.

1993 • 200 citations

Regulation of nitric oxide synthase by nitric oxide.

1993 • 197 citations

Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils

1991 • 195 citations

Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole.

1993 • 194 citations

Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.

1993 • 192 citations

Effects of acute nitric oxide inhibition on rat glomerular microcirculation

1991 • 189 citations

Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney.

1994 • 185 citations

Cytokine-induced expression of a nitric oxide synthase in rat renal tubule cells.

1993 • 184 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Immunological detection of nitric oxide synthase(s) in human tissues using heterologous antibodies suggesting different isoforms

1992 • 181 citations

Inhibition of nitric oxide synthesis attenuates pressure-induced natriuretic responses in anesthetized dogs

1993 • 178 citations

Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus

1989 • 174 citations

Endothelium-derived relaxing factor inhibits renin release

1988 • 165 citations

Role of the endothelium-dependent relaxing factor nitric oxide on renal function.

1992 • 163 citations

Modulation by prostaglandin synthesis inhibitors of the action of exogenous angiotensin II on glomerular ultrafiltration in the rat.

1978 • 162 citations

Pathobiology of Endothelial and Other Vascular Cells in Diabetes Mellitus: Call for Data

1991 • 145 citations

Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells

1990 • 142 citations

Locally produced EDRF controls preglomerular resistance and ultrafiltration coefficient

1993 • 141 citations

Glomeruli synthesize nitrite in experimental nephrotoxic nephritis

1990 • 137 citations

Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism.

1990 • 131 citations

Interleukin 1β and tumour necrosis factor α induce a macrophage‐type of nitric oxide synthase in rat renal mesangial cells

1992 • 126 citations

Effects of endothelium-derived relaxing factor and nitric oxide on rat mesangial cells

1990 • 126 citations

Endothelium-derived relaxing factor inhibits transport and increases cGMP content in cultured mouse cortical collecting duct cells.

1992 • 125 citations

INTRACELLULAR LOCALISATION OF DEHYDROGENASE SYSTEMS USING MONOTETRAZOLIUM SALTS AND METAL CHELATION OF THEIR FORMAZANS

1957 • 124 citations

Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells.

1993 • 123 citations

Sodium and angiotensin in hypertension induced by long-term nitric oxide blockade.

1993 • 120 citations

Purification and characterization of a human NO synthase

1991 • 115 citations

Nitric oxide decreases cytosolic free calcium in Balb/c 3T3 fibroblasts by a cyclic GMP-independent mechanism.

1991 • 115 citations

Suppression of blood flow autoregulation plateau during nitric oxide blockade in canine kidney

1992 • 113 citations

Blockade of pressure natriuresis induced by inhibition of renal synthesis of nitric oxide in dogs

1992 • 110 citations

Cross‐talk between transmembrane signalling systems: a prerequisite for the delicate regulation of glomerular haemodynamics by mesangial cells

1989 • 109 citations

EDRF-angiotensin II interactions in rat juxtamedullary afferent and efferent arterioles

1992 • 107 citations

Endothelium modulates renal blood flow but not autoregulation

1992 • 106 citations

Interleukin-1 β induces the production of an L-arginine-derived relaxing factor from cultured smooth muscle cells from rat aorta

1991 • 104 citations

Synthesis and action of nitric oxide in rat glomerular mesangial cells

1991 • 100 citations

The involvement of endothelium‐derived relaxing factor in the regulation of renal cortical blood flow in the rat

1991 • 99 citations

Effects of NG-monomethyl-L-arginine and L-arginine on acetylcholine renal response.

1990 • 99 citations

Nitric oxide modulates vascular tone in preglomerular arterioles.

1992 • 94 citations

Renal nitric oxide and angiotensin II interaction in renovascular hypertension.

1993 • 91 citations

Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney.

1993 • 89 citations

Importance of NO/EDRF for glomerular and tubular function: Studies in the isolated perfused rat kidney

1992 • 88 citations

Nitric oxide gas: mediator, modulator, and pathophysiologic entity.

1992 • 88 citations

Endothelium-derived relaxing factor regulates renin release in vivo

1992 • 87 citations

Nitric Oxide: An Inflammatory Mediator of Glomerular Mesangial Cells

1993 • 87 citations

Endothelium-derived NO stimulates pressure-dependent renin release in conscious dogs

1993 • 85 citations

Effects of interferon-gamma on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cells.

1992 • 84 citations

Mediatory Role of Endothelium-Derived Nitric Oxide in Renal Vasodilatory and Excretory Effects of Bradykinin

1991 • 82 citations

Relaxation of sheep cerebral arteries by vasoactive intestinal polypeptide and neurogenic stimulation: inhibition by <scp>l</scp>‐N^G‐monomethyl arginine in endothelium‐denuded vessels

1991 • 82 citations

Induction of Nitric Oxide Synthase in Human Mesangial Cells

1993 • 81 citations

Role of nitric oxide in mediating renal response to volume expansion.

1992 • 76 citations

Glomeruli synthesize nitrite in active Heymann nephritis; the source is infiltrating macrophages

1991 • 76 citations

Role of NO on pressure-natriuresis in Wistar-Kyoto and spontaneously hypertensive rats

1993 • 73 citations

Glomerular NO synthase activity in mesangial cell immune injury.

1993 • 73 citations

Nonprostanoid endothelium-derived factors inhibit renin release.

1992 • 72 citations

Role of endothelium-derived relaxing factor in renal autoregulation in conscious dogs

1992 • 70 citations

Renal effects of acute endothelial-derived relaxing factor blockade are not mediated by angiotensin II

1993 • 69 citations

Liberators of NO exert a dual effect on renin secretion from isolated mouse renal juxtaglomerular cells

1993 • 69 citations

Pressure natriuresis in rats during blockade of the L-arginine/nitric oxide pathway.

1992 • 68 citations

A mechanism by which atrial natriuretic factor mediates its glomerular actions

1986 • 65 citations

Mechanism of vasodilation by molsidomine

1985 • 60 citations

Endothelium-derived relaxing factor influences renal vascular resistance

1990 • 59 citations

Characterization of a nitric‐oxide‐catalysed ADP‐ribosylation of glyceraldehyde‐3‐phosphate dehydrogenase

1992 • 58 citations

Role of nitric oxide in hemodialysis hypotension.

1992 • 56 citations

Decreased renin release and constant kallikrein secretion after injection of L-NAME in isolated perfused rat kidney

1992 • 56 citations

Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells.

1991 • 55 citations

Glomerular nitrite synthesis in in situ immune complex glomerulonephritis in the rat.

1991 • 54 citations

Nitric oxide synthases in the cardiovascular system

1993 • 50 citations

Influence of endothelium-derived relaxing factor on renal microvessels and pressure-dependent vasodilation

1993 • 49 citations

Arginine synthesis in mouse and rabbit nephron: localization and functional significance

1993 • 49 citations

Glucose-6-phosphate dehydrogenase and renin in kidneys of hypertensive or adrenalectomized rats

1959 • 48 citations

Formation of endothelium-derived relaxing factor in porcine kidney epithelial LLC-PK1 cells: an intra- and intercellular messenger for activation of soluble guanylate cyclase.

1991 • 47 citations

Role of prostaglandins and endothelium-derived relaxing factor on the renal response to acetylcholine

1991 • 47 citations

Immunolocalization of soluble guanylyl cyclase subunits in rat kidney

1995 • 47 citations

Acute and Chronic Inhibition of Nitric Oxide Synthase in Conscious Rabbits

1993 • 44 citations

Role of renal interstitial pressure as a mediator of sodium retention during systemic blockade of nitric oxide.

1993 • 43 citations

Cloning and Expression of a Rat Neuronal Nitric Oxide Synthase Coding Sequence in a Baculovirus/Insect Cell System

1993 • 43 citations

Effect of arginine depletion on glomerular and tubular kidney function: studies in isolated perfused rat kidneys

1991 • 39 citations

Endothelium-derived relaxing and contracting factors

1990 • 35 citations

Nitric oxide synthase responsible for <scp>l</scp>‐arginine‐induced relaxation of rat aortic rings in vitro may be an inducible type

1992 • 32 citations

Localization of cGMP after infusion of ANP or nitroprusside in the maturing rat

1992 • 31 citations

Evidences for the Existence of Endothelium-Derived Relaxing Factor in the Renal Medulla

1990 • 31 citations

Metabolism of arginine by the isolated perfused rat kidney

1978 • 30 citations

Role of nitric oxide in long-term angiotensin II-induced renal vasoconstriction.

1993 • 26 citations

Ultrastructural Localization of Nitric Oxide Synthase in Intima of Rabbit Aorta

1993 • 23 citations

Zonal Changes of Guanidine 3’ 5’ -Cyclic Monophosphate Related to Endothelium-Derived Relaxing Factor in Dog Renal Medulla

1992 • 20 citations

The participation of the endothelium in the control of renin release

1991 • 19 citations

The participation of the endothelium in the control of renin release

1991 • 9 citations

Quantitative measurement of glucose-6-phosphate dehydrogenase in cortical fractions of the rabbit nephron

1979 • 9 citations

Quantitation of glucose-6-phosphate dehydrogenase activity in cortical fractions of the nephron in sodium-depleted and sodium-loaded rabbits

1980 • 6 citations

Human erythropoietin improves the blood platelet phospholipid composition in chronically hemodialyzed patients.

1995 • 6 citations