Nitric oxide synthase responsible for <scp>l</scp>‐arginine‐induced relaxation of rat aortic rings in vitro may be an inducible type

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

1985 • 1,266 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

<scp>l</scp>‐N^G‐nitro arginine (<scp>l</scp>‐NOARG), a novel, <scp>l</scp>‐arginine‐reversible inhibitor of endothelium‐dependent vasodilatation in vitro

1990 • 769 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1990 • 700 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

1990 • 455 citations

Arginine is a physiological precursor of endothelium-derived nitric oxide

1988 • 392 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

Human vascular smooth muscle cells. Target for and source of tumor necrosis factor.

1989 • 333 citations

Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite

1981 • 318 citations

The effects of L‐arginine and N^G‐monomethyl L‐arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation

1989 • 313 citations

Characterization of the Effects of Endotoxin on Macrophage Tumor Cell Killing

1978 • 298 citations

NG-nitro-L-arginine (N5-[imino(nitroamino)methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from l-arginine

1990 • 269 citations

<scp>l</scp>‐N^G‐monomethyl arginine and <scp>l</scp>‐N^G‐nitro arginine inhibit non‐adrenergic, non‐cholinergic relaxation of the mouse anococcygeus muscle

1990 • 201 citations

Incubation with endotoxin activates the L-arginine pathway in vascular tissue

1990 • 193 citations

Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide.

1990 • 191 citations

Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide

1989 • 156 citations

L-Arginine-dependent production of nitrogen oxides by rat pulmonary macrophages

1991 • 123 citations

Inducible but not constitutive production of nitric oxide by vascular smooth muscle cells

1991 • 98 citations

Nitric oxide from vascular smooth muscle cells: regulation of platelet reactivity and smooth muscle cell guanylate cyclase

1991 • 89 citations

Influence of natural and recombinant interleukin 2 on endothelial cell arachidonate metabolism. Induction of de novo synthesis of prostaglandin H synthase.

1988 • 71 citations

Histamine potentiation of nerve- and drug-induced responses of a rabbit cerebral artery.

1975 • 66 citations

Is arginine a physiological precursor of endothelium-derived nitric oxide?

1988 • 66 citations

Coronary vasodilatation induced by endotoxin in the rabbit isolated perfused heart is nitric oxide‐dependent and inhibited by dexamethasone

1991 • 66 citations

Nitric oxide synthase inhibitors inhibit interleukin-1 beta-induced depression of vascular smooth muscle.

1991 • 45 citations

Mechanism of glucocorticoid regulation of alkaline phosphatase gene expression in osteoblast‐like cells

1990 • 43 citations

<scp>l</scp>‐Arginine induces relaxation of rat aorta possibly through non‐endothelial nitric oxide formation

1991 • 40 citations

Three regulation mechanisms of nitric oxide synthase

1991 • 36 citations

Anti-inflammatory steroids inhibit cytokine induction of nitric oxide synthase in rat renal mesangial cells

1991 • 29 citations

Angiotensin converting enzyme induction by cyclic AMP and analogues in cultured endothelial cells

1987 • 12 citations

Possible mechanism of arginine-induced vasodilation

1990 • 2 citations