Role of Human Cytochromes P450 in the Metabolic Activation of Chemical Carcinogens and Toxins

Methods in Enzymology , Vol

1966 • 26,261 citations

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1991 • 1,173 citations

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1991 • 997 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1991 • 671 citations

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1992 • 605 citations

Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma

1973 • 601 citations

Oxidative and reductive metabolism by cytochrome P450 2E1

1992 • 557 citations

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.

1991 • 547 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

1987 • 475 citations

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites

1992 • 417 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

Expression of Bovine 17α-Hydroxylase Cytochrome P-450 cDNA in Nonsteroidogenic (COS 1) Cells

1986 • 389 citations

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1990 • 387 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

1989 • 349 citations

Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas

1990 • 330 citations

Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family.

1987 • 317 citations

Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

1992 • 312 citations

Effect of smoking on caffeine clearance

1978 • 301 citations

Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

1990 • 291 citations

High Susceptibility to Lung Cancer Analyzed in Terms of Combined Genotypes of P450IA1 and Mu‐class Glutathione S‐Transferase Genes

1992 • 284 citations

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

1990 • 281 citations

Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization

1989 • 277 citations

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.

1982 • 269 citations

Purification and characterization of human liver microsomal cytochrome P-450 2A6.

1991 • 267 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

1991 • 258 citations

Characterization of Human Microsomal Cytochrome P-450 Enzymes

1989 • 244 citations

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

1990 • 236 citations

A tobacco smoke-derived nitrosamine, 4-(methytnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytocbrome P450s including the polymorphic human cytochrome P4502D6

1991 • 235 citations

Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

1992 • 230 citations

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

1992 • 228 citations

Identification of a polymorphically expressed member of the human cytochrome P-450III family.

1989 • 224 citations

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

1991 • 222 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Multiple mechanisms in the regulation of ethanol‐inducible cytochrome P450IIE1

1990 • 199 citations

Stabilization of Cytochrome P450j Messenger Ribonucleic Acid in the Diabetic Rat

1987 • 199 citations

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

1990 • 193 citations

Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver.

1990 • 191 citations

Genetic polymorphism of cytochrome P4502E1 in a Swedish population

1993 • 189 citations

Variability in nifedipine pharmacokinetics and dynamics: A new oxidation polymorphism in man

1984 • 182 citations

Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.

1991 • 176 citations

Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine

1992 • 172 citations

Expression of CYP1A1 and CYP1A2 genes in human liver

1993 • 165 citations

Human CYP1A1 (cytochrome P1450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population

1991 • 163 citations

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

1989 • 159 citations

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

1992 • 149 citations

Metabolism of N-nitrosodialkylamines by human liver microsomes.

1988 • 149 citations

cDNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment

1991 • 143 citations

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA

1990 • 143 citations

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing

1991 • 142 citations

Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence

1991 • 138 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Effect of cigarette smoking on phenacetin metabolism

1974 • 133 citations

Molecular genetics of the debrisoquin-sparteine polymorphism

1991 • 132 citations

The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease

1992 • 132 citations

Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake

1989 • 131 citations

The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finish study population

1993 • 129 citations

Role of phospholipids in reconstituted cytochrome P 450 3A form and mechanism of their activation of catalytic activity

1992 • 124 citations

Inter-Species Variations in the Metabolism of Xenobiotics

1974 • 120 citations

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

1992 • 120 citations

Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping

1989 • 120 citations

Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1

1992 • 118 citations

Cytochrome P450IIE1 Is Elevated in Lymphocytes from Poorly Controlled Insulin-Dependent Diabetics^*

1990 • 116 citations

Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

1987 • 112 citations

High‐level expression of functional human cytochrome P450 1A2 in Escherichia coli

1992 • 111 citations

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.

1992 • 111 citations

Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.

1986 • 110 citations

The caffeine CO2 breath test: Dose response and route of N-demethylation in smokers and nonsmokers

1982 • 106 citations

Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes

1988 • 104 citations

The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping

1990 • 98 citations

Caffeine as a probe for human cytochromes P450

1992 • 95 citations

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1987 • 91 citations

Expression of human liver cytochrome P450 IIIA4 in yeast

1990 • 91 citations

Defective provirus form of human T-cell leukemia virus type I in adult T-cell leukemia/lymphoma: clinicopathological features.

1991 • 90 citations

Optimization of yeast‐expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH‐cytochrome P450 reductase and cytochrome b₅

1992 • 88 citations

Comparison of a novel thin-layer chromatographic—fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine

1992 • 87 citations

Cytochrome P450 gene expression and regulation

1985 • 85 citations

Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus

1989 • 83 citations

Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene

1989 • 79 citations

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

1991 • 74 citations

Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity

1989 • 72 citations

Evolution of Cytochrome P-450 Proteins

1988 • 71 citations

The pharmacogenetics of chemical carcinogenesis

1992 • 64 citations

Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells.

1987 • 62 citations

cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC).

1987 • 61 citations

Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6

1993 • 59 citations

Monoclonal Antibody-Directed Radioimmunoassay Detects Cytochrome P-450 in Human Placenta and Lymphocytes

1985 • 56 citations

Constitutive and inducible expression of human cytochrome P450IA1 in yeast Saccharomyces cerevisiae: An alternative enzyme source for in vitro studies

1990 • 52 citations

Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae

1991 • 50 citations

Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system.

1989 • 46 citations

Characterization of Rat Cytochrome P-450MC Synthesized in Saccharomyces cerevisiae1

1985 • 45 citations

Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

1992 • 43 citations

Genetic polymorphism of cytochromes P450: Interethnic differences and relationship to incidence of lung cancer

1992 • 43 citations

Role of cytochrome P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes.

1992 • 41 citations

Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene.

1993 • 41 citations

Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples

1991 • 40 citations

Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer

1992 • 39 citations

Baculovirus-mediated expression and functional characterization of human NADPH-P450 oxidoreductase

1992 • 38 citations

Pharmacokinetics of Nifedipine Slow Release Tablet in Mexican Subjects: Further Evidence for an Oxidation Polymorphism

1989 • 37 citations

The metabolism of 1-nitropyrene by human cytochromes P450

1990 • 36 citations

Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

1993 • 31 citations

Transduction of cytochrome P3-450 by retroviruses: constitutive expression of enzymatically active microsomal hemoprotein in animal cells

1989 • 30 citations

Cytochrome P-450 3A4 (nifedipine oxidase) is responsible for the C-oxidative metabolism of 1-nitropyrene in human liver microsomal samples.

1992 • 23 citations

The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetate-induced carcinogenesis in rats

1991 • 18 citations

Deficient nifedipine oxidation: a rare inherited trait associated with cystic fibrosis kindreds

1992 • 15 citations

Deleted Work

1955 • 0 citations