Role of cytochrome P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes.

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.

1989 • 303 citations

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

1992 • 228 citations

Identification of a polymorphically expressed member of the human cytochrome P-450III family.

1989 • 224 citations

Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver.

1990 • 191 citations

Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation.

1989 • 179 citations

Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P₄₅₀, compared with three further P₄₅₀-isoenzymes, NADPH P₄₅₀-reductase, glutathione transferases and microsomal epoxide hydrolase

1984 • 152 citations

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

1986 • 142 citations

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards.

1988 • 138 citations

Intensely potent morpholinyl anthracyclines

1984 • 136 citations

Characterization of mRNA Species Related to Human Liver Cytochrome P-450 Nifedipine Oxidase and the Regulation of Catalytic Activity

1989 • 123 citations

Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 α-ethinyloestradiol. Relative activities of rat and human liver enzymes

1990 • 79 citations

In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins

1987 • 69 citations

Cytochrome P-450-mediated O-demethylation: a route in the metabolic activation of etoposide (VP-16-213).

1987 • 66 citations

Interaction of Anticancer Drugs with Hepatic Monooxygenase Enzymes

1989 • 62 citations

Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat

1985 • 60 citations

Relative contribution of various forms of cytochrome P450 to the metabolism of benzo[a]pyrene by human liver microsomes

1989 • 56 citations

Metabolism and activation of N-nitrosodimethylamine by hamster and rat microsomes: comparative study with weanling and adult animals.

1987 • 54 citations

Dissociation of Antitumor Potency from Anthracycline Cardiotoxicity in a Doxorubicin Analog

1985 • 49 citations

Isolation of a high spin form of cytochrome P-450 induced in rat liver by 3-methylcholanthrene

1983 • 46 citations

Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N''-triethylenethiophosphoramide.

1989 • 44 citations

Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and-resistant P388 cells

1986 • 41 citations

Comparative cytotoxicities of various morpholinyl anthracyclines

1985 • 39 citations

Association of DNA Cross-Linking With Potentiation of the Morpholino Derivative of Doxorubicin by Human Liver Microsomes

1989 • 29 citations

Effects of 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin and doxorubicin on the survival, DNA integrity, and nucleolar morphology of human leukemia cells in vitro.

1986 • 25 citations

Stereochemistry of Cytochrome P-450 Reactions

1989 • 20 citations

DNA crosslinking by 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin in HT-29 human colon carcinoma cells in vitro

1985 • 18 citations