Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

Striatal Dysfunction in Attention Deficit and Hyperkinetic Disorder

1989 • 556 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Focal Cerebral Hypoperfusion in Children With Dysphasia and/or Attention Deficit Disorder

1984 • 502 citations

Central Nervous System Toxicity after Liver Transplantation

1987 • 500 citations

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

1987 • 475 citations

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

1989 • 349 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.

1989 • 303 citations

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 • 292 citations

THE FRONTAL LOBES AND THE REGULATION OF BEHAVIOR

1973 • 267 citations

Hormones and Resistance

1971 • 223 citations

OPTIMIZATION OF CYCLOSPORINE THERAPY IN RENAL TRANSPLANTATION BY A PHARMACOKINETIC STRATEGY

1988 • 193 citations

Impaired oxidation of debrisoquine in patients with perhexiline liver injury.

1984 • 162 citations

Induction of microsomal cytochrome P-450 enzymes: The first Bernard B. Brodie lecture at Pennsylvania State University

1986 • 161 citations

Genetically determined polymorphisms in drug oxidation

1986 • 88 citations

Magnetic resonance technology in human brain science: Blueprint for a program based upon morphometry

1989 • 81 citations

Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats.

1987 • 61 citations

Cyclosporin A pharmacokinetics in liver transplant recipients in relation to biliary T-tube clamping and liver dysfunction.

1989 • 50 citations

The striatum: a fine tuner of the brain.

1982 • 45 citations

Absorption of Cyclosporine from Rabbit Small Intestine In Situ

1986 • 26 citations

Differential Effects of β-Naphthoflavone and Pregnenolone-16α-carbonitrile on Dimethylnitrosamine-Induced Hepatocarcinogenesis<xref ref-type="fn" rid="FN2">2</xref>

1978 • 25 citations

Liquid-chromatographic analysis for cyclosporine with use of a microbore column and small sample volume.

1986 • 24 citations