Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

[12] High-efficiency transformation of yeast by electroporation

1991 • 798 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol.

1985 • 412 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4

1989 • 264 citations

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

1992 • 228 citations

Tolbutamide hydroxylation by human liver microsomes

1988 • 198 citations

Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.

1988 • 161 citations

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

1991 • 98 citations

Expression of human liver cytochrome P450 IIIA4 in yeast

1990 • 91 citations

The Utility of p-Mtrophenol Hydroxylation in P450iie1 Analysis

1989 • 88 citations

[8] Expression of mammalian cytochrome P450 using vaccinia virus

1991 • 76 citations

Inhibition of sparteine oxidation in human liver by tricyclic antidepressants and other drugs

1983 • 61 citations

Mephenytoin hydroxylation polymorphism: Characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

1985 • 54 citations

Debrisoquine oxidation phenotype and susceptibility to lung cancer.

1990 • 51 citations

Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system.

1989 • 46 citations

[13] Expression of cytochrome P450 cDNAs in human B lymphoblastoid cells: Applications to toxicology and metabolite analysis

1991 • 41 citations

[10] Heterologous expression of mammalian P450 in COS cells

1991 • 38 citations

Evidence in humans for variant allozymes of the nondeficient sparteine/debrisoquine monooxygenase (P45OIID 1) in vitro.

1989 • 28 citations

The expression of human cytochrome P450IA1 in the yeast Saccharomyces cerevisiae

1991 • 24 citations

Inhibition of lignocaine metabolism by β-adrenoceptor antagonists in rat and human liver microsomes

1989 • 12 citations

Cloning of human cytochrome P-450 cDNA and its expression in Saccharomyces cerevisiae.

1989 • 6 citations