Dendritic cell origins: Puzzles and paradoxes

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response

1997 • 1,536 citations

The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand

1997 • 1,224 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 1,041 citations

CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.

1996 • 962 citations

Epidermal Langerhans cells are derived from cells originating in bone marrow

1979 • 879 citations

Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking

1998 • 832 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 694 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.

1994 • 626 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Transforming Growth Factor β1, in the Presence of Granulocyte/Macrophage Colony-stimulating Factor and Interleukin 4, Induces Differentiation of Human Peripheral Blood Monocytes into Dendritic Langerhans Cells

1998 • 507 citations

Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin

1997 • 482 citations

A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells

1996 • 479 citations

Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow.

1992 • 452 citations

RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells

1998 • 443 citations

Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow.

1993 • 428 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells

1997 • 402 citations

Characterization of nonlymphoid cells derived from rat peripheral lymph

1983 • 343 citations

TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors.

1996 • 312 citations

Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha.

1995 • 296 citations

High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes

1997 • 292 citations

Dendritic Cell Development in Culture from Thymic Precursor Cells in the Absence of Granulocyte/Macrophage Colony-stimulating Factor

1996 • 265 citations

TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages

1992 • 257 citations

Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse

1999 • 244 citations

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate

1996 • 235 citations

Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.

1993 • 233 citations

Cell-Autonomous Defects in Dendritic Cell Populations of Ikaros Mutant Mice Point to a Developmental Relationship with the Lymphoid Lineage

1997 • 221 citations

Dendritic Cell Development: Multiple Pathways to Nature's Adjuvants

1997 • 217 citations

Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes

1996 • 212 citations

CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells

1996 • 200 citations

Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin.

1988 • 197 citations

Karyometrische Untersuchungen an Lymphknotenzellen des Menschen

1958 • 178 citations

A Skin Homing Molecule Defines the Langerhans Cell Progenitor in Human Peripheral Blood

1997 • 173 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

CD4+ blood dendritic cells are potent producers of IFN-alpha in response to in vitro HIV-1 infection.

1994 • 152 citations

Dendritic cells : biology and clinical applications

1999 • 151 citations

Identification of CD68+lin− Peripheral Blood Cells with Dendritic Precursor Characteristics

1998 • 141 citations

Dendritic Cells: Biology and Clinical Applications

1999 • 139 citations

Identification of Cord Blood Dendritic Cells as an Immature CD11c− Population

1999 • 134 citations

A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice.

1997 • 125 citations

Malignant lymphoma of plasmacytoid T-cells

1983 • 125 citations

Identification of a Common Developmental Pathway for Thymic Natural Killer Cells and Dendritic Cells

1998 • 123 citations

The linkage between T‐cell and dendritic cell development in the mouse thymus

1998 • 118 citations

The Cell Surface Phenotype of Human Natural Interferon‐α Producing Cells as Determined by Flow Cytometry

1996 • 116 citations

In vivo migration of dendritic cells differentiated in vitro: a chimpanzee model.

1997 • 103 citations

"Cocktail"-coronary care.

1984 • 100 citations

Leukemia-Associated Lymph Node Infiltrates of Plasmacytoid Monocytes (So-called Plasmacytoid T-cells) Evidence for Two Distinct Histological and Immunophenotypical Patterns

1990 • 92 citations

T-ASSOCIATED PLASMA-CELLS

1975 • 90 citations

Transforming Growth Factor-β1 Polarizes Murine Hematopoietic Progenitor Cells to Generate Langerhans Cell-Like Dendritic Cells Through a Monocyte/Macrophage Differentiation Pathway

1999 • 89 citations

Identification of a Committed T Cell Precursor Population in Adult Human Peripheral Blood

1997 • 72 citations

Plasmacytoid T-cell lymphoma associated with chronic myeloproliferative disorder

1985 • 66 citations

Cytogenetic Identification of Allogeneic Epidermal Langerhans Cells in a Bone-Marrow–Graft Recipient

1984 • 60 citations

CD4 and CD8 expression by human and mouse thymic dendritic cells

1994 • 59 citations

Plasmacytoid monocyte proliferation associated with myeloproliferative disorders

1992 • 57 citations

T‐zone lymphoma with predominance of ‘plasmacytoid T‐cells’ associated with myelomonocytic leukaemia—a distinct clinicopathological entity

1986 • 53 citations

Immunocytology of plasmacytoid T cells: Marker analysis indicates a unique phenotype of this enigmatic cell

1987 • 50 citations

Plasmacytoid Monocytes in Jessnerʼs Lymphocytic Infiltration of the Skin

1990 • 42 citations

Identification of Plasmacytoid T Cells in Lymphoid Hyperplasia of the Skin

1989 • 36 citations

ONTOGENY OF HUMAN EPIDERMAL LANGERHANS CELLS

1984 • 26 citations

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