TNFα and IL-1β mediate intercellular adhesion molecule-1 induction via microglia–astrocyte interaction in CNS radiation injury

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Therapeutic irradiation and brain injury

1980 • 985 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains.

1992 • 651 citations

Radiation response of the central nervous system

1995 • 649 citations

Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.

1992 • 617 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha.

1994 • 421 citations

Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.

1996 • 415 citations

Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat

1995 • 346 citations

Closed Head Injury Triggers Early Production of TNFα and IL-6 by Brain Tissue

1994 • 344 citations

Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines

1994 • 343 citations

Induction of acute phase gene expression by brain irradiation

1995 • 338 citations

Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant

1997 • 332 citations

Cytokines and the nervous system I: expression and recognition

1995 • 307 citations

Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats

1997 • 233 citations

Cytokines and adhesion molecules in stroke and related diseases

1996 • 218 citations

Experimental brain injury induces expression of interleukin-1β mRNA in the rat brain

1995 • 217 citations

Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule

1991 • 207 citations

The Impact of Microglia-Derived Cytokines upon Gliosis in the CNS

1994 • 195 citations

Interleukin‐1β Induces Prostaglandin G/H Synthase‐2 (Cyclooxygenase‐2) in Primary Murine Astrocyte Cultures

1996 • 190 citations

Antibodies against Adhesion Molecules Reduce Apoptosis after Transient Middle Cerebral Artery Occlusion in Rat Brain

1996 • 188 citations

Radiation-induced astrocytic and microglial responses in mouse brain

1993 • 184 citations

Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture

1994 • 181 citations

Maturational Regulation and Regional Induction of Cyclooxygenase-2 in Rat Brain: Implications for Alzheimer's Disease

1997 • 175 citations

Intercellular adhesion molecule 1 knockout abrogates radiation induced pulmonary inflammation

1997 • 170 citations

Delayed molecular responses to brain irradiation

1997 • 161 citations

Late and persistent up-regulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro

1997 • 159 citations

Disruption of the blood-brain barrier as the primary effect of CNS irradiation

1994 • 154 citations

Induction of cyclo-oxygenase 2 in brains of patients with Downʼs syndrome and dementia of Alzheimer type

1997 • 152 citations

Progressive expression of immunomolecules on activated microglia and invading leukocytes following focal cerebral ischemia in the rat

1996 • 147 citations

Prostaglandin H Synthetase‐Mediated Metabolism of Dopamine: Implication for Parkinson's Disease

1995 • 143 citations

Vascular Activation of Adhesion Molecule mRNA and Cell Surface Expression by Ionizing Radiation

1998 • 130 citations

Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-α, interleukin-1β, and interferon-γ in astrocytes

1994 • 129 citations

Head Injury Induces Increased Prostaglandin Synthesis in Rat Brain

1987 • 125 citations

Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines

1992 • 122 citations

Differential Expression of ICAM-1, VCAM-1 and Their Ligands LFA-1, Mac-1, CD43, VLA-4, and MHC Class II Antigens in MurineToxoplasmaEncephalitis: A Light Microscopic and Ultrastructural Immunohistochemical Study

1994 • 110 citations

Cell adhesion molecules on vessels during inflammation in the mouse central nervous system

1994 • 105 citations

Histological changes in the normal rat brain after gamma irradiation

1996 • 105 citations

Brain peptides and glial growth. I. Glia-promoting factors as regulators of gliogenesis in the developing and injured central nervous system.

1986 • 104 citations

Experimental Traumatic Brain Injury Elevates Brain Prostaglandin E₂and Thromboxane B₂Levels in Rats

1988 • 104 citations

Radiation enhances tumor necrosis factor α production by murine brain cells

1991 • 100 citations

Prostaglandin E₂ Induces Interleukin‐6 Synthesis in Human Astrocytoma Cells

1997 • 98 citations

Microglial secretion products and their impact on the nervous system.

1993 • 98 citations

Improved survival duration in patients with unresected solitary brain metastasis using accelerated hyperfractionated radiation therapy at total doses of 54.4 gray and greater results of radiation therapy oncology group 85–28

1993 • 90 citations

Radiation dose response of normal brain

1988 • 80 citations

Cellular Responses to Experimental Brain Injury

1995 • 69 citations

ICAM-1 Induction in the Mouse CNS Following Irradiation

1997 • 65 citations

Increasing radiation dose intensity using hyperfractionation in patients with malignant glioma

1992 • 63 citations

Establishment of the role of IL-6 and TNF receptor 1 using gene knockout mice

1994 • 62 citations

Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murine oligodendrocytes and astrocytes

1991 • 58 citations

Adhesion to human neurons and astrocytes of monocytes: the role of interaction of CR3 and ICAM-1 and modulation by cytokines

1995 • 55 citations

Lymphocyte adhesion to brain capillary endothelial cells in vitro

1994 • 53 citations

Interleukin 1‐β‐ and tumor necrosis factor‐α‐mediated regulation of ICAM‐1 gene expression in astrocytes requires protein kinase C activity

1995 • 52 citations

Brain microvascular endothelial cells and leukocytes derived from patients with multiple sclerosis exhibit increased adhesion capacity

1997 • 45 citations

Blood-brain barrier breakdown and increased intercellular adhesion molecule (ICAM-1/CD54) expression after Semliki Forest ( A7) virus infection facilitates the development of experimental allergic encephalomyelitis

1996 • 39 citations

Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2

1992 • 37 citations

Expression of Intercellular Adhesion Molecule-1 and Lymphocyte Function-Associated Antigen-1 on Alveolar Macrophages in the Acute Stage of Radiation-Induced Lung Injury in Rats

1997 • 34 citations

Expression of CD54 (intercellular adhesion molecule-1) and the beta 1 integrin CD29 is modulated by a cyclic AMP dependent pathway in activated primary rat microglial cell cultures.

1998 • 20 citations

Progressive perturbations in cerebral energy metabolism after experimental whole-brain radiation in the therapeutic range

1994 • 19 citations

Effects of Prostaglandin E₂on Brain Edema and Liver Histopathology in A Galactosamine-Induced Fulminant Hepatic Failure Rat Model

1987 • 17 citations

Construction of quantitative RT-PCR MIMICs.

1995 • 14 citations

Altered Acute Phase Responses to Inflammation in IL‐1 and TNF Receptor Knockout Mice^a

1997 • 11 citations

Anti-Adhesion Molecule Monoclonal Antibodies

1996 • 4 citations