Establishment of the role of IL-6 and TNF receptor 1 using gene knockout mice

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

Interleukin-6: An Overview

1990 • 1,910 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

THE PHENOMENON OF THE ACUTE PHASE RESPONSE*

1982 • 1,498 citations

Interleukin-6 in Biology and Medicine

1993 • 1,398 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

ENDOTOXINS AND DISEASE MECHANISMS

1987 • 1,119 citations

Galactosamine-induced sensitization to the lethal effects of endotoxin.

1979 • 940 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.

1994 • 738 citations

Enhanced NK cell activity in mice injected with interferon and interferon inducers

1978 • 735 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection.

1985 • 555 citations

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

1988 • 537 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.

1988 • 382 citations

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.

1988 • 365 citations

Endogenous tumor necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection

1988 • 353 citations

Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide.

1993 • 352 citations

The acute phase response to injury and infection

1985 • 332 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma.

1986 • 328 citations

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

1994 • 305 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice.

1988 • 247 citations

T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor.

1988 • 244 citations

Production of tumor necrosis factor during murine listeriosis.

1987 • 241 citations

Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality

1991 • 239 citations

A T cell-independent mechanism of macrophage activation by interferon-gamma.

1987 • 239 citations

Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

1992 • 206 citations

Positive self regulation of cytotoxicity in human natural killer cells by production of interferon upon exposure to influenza and herpes viruses.

1982 • 188 citations

Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines.

1988 • 164 citations

Interleukin 2 enhances natural killer cell activity through induction of gamma interferon

1983 • 134 citations

Human gamma interferon and tumor necrosis factor exert a synergistic blockade on the replication of herpes simplex virus

1989 • 126 citations

Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor.

1993 • 106 citations

Constitutive synthesis of tumor necrosis factor in the thymus.

1992 • 93 citations

Accessory signals in murine cytolytic T cell responses. Dual requirement for IL-1 and IL-6.

1989 • 90 citations

Induction of receptors for tumor necrosis factor-alpha by interferons is not a major mechanism for their synergistic cytotoxic response.

1987 • 76 citations

Interferon‐γ induces cell surface expression for both types of tumor necrosis factor receptors

1992 • 66 citations

Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development.

1992 • 64 citations

Impaired Generation of Anti‐Viral Cytotoxicity against Lymphocytic Choriomeningitis and Vaccinia Virus in Mice Treated with CD4‐Specific Monoclonal Antibody

1989 • 56 citations

Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model.

1986 • 50 citations

Expression of tumor necrosis factor at a specific developmental stage of mouse embryos

1989 • 38 citations

The role of interleukin-6 in development

1992 • 38 citations

Role of tumor necrosis factor in Listeria resistance of nude mice

1990 • 32 citations