Single-chain immunotoxin fusions between anti-tac and Pseudomonas exotoxin: Relative importance of the two toxin disulfide bonds

Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli.

1988 • 1,536 citations

Single-Chain Antigen-Binding Proteins

1988 • 1,450 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli

1987 • 449 citations

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

1989 • 420 citations

A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies

1992 • 343 citations

Recombinant Toxins for Cancer Treatment

1991 • 308 citations

In Vivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein

1990 • 304 citations

Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity.

1990 • 267 citations

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

1990 • 233 citations

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

1991 • 219 citations

Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.

1991 • 213 citations

Functional Analysis of Domains II, Ib, and III of Pseudomonas exotoxin

1989 • 193 citations

Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol.

1992 • 158 citations

A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins.

1990 • 156 citations

Anti-Tac(Fv)-PE40, a single chain antibody Pseudomonas fusion protein directed at interleukin 2 receptor bearing cells.

1990 • 94 citations

Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections.

1992 • 91 citations

Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv).

1991 • 81 citations

A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin.

1990 • 80 citations

The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia.

1990 • 80 citations

Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.

1990 • 69 citations

IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes.

1990 • 41 citations

Effects of eliminating a disulfide bridge within domain II of Pseudomonas aeruginosa exotoxin A

1989 • 35 citations

Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins.

1989 • 30 citations

Cytotoxic activity of a recombinant fusion protein between insulin-like growth factor I and Pseudomonas exotoxin.

1991 • 29 citations

Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor.

1992 • 27 citations

A recombinant, membrane-acting immunotoxin.

1991 • 27 citations