Enhanced expression of heat shock proteins in gradually dying cells and their release from necrotically dead cells

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

2002 • 3,280 citations

THE FUNCTION OF HEAT-SHOCK PROTEINS IN STRESS TOLERANCE: DEGRADATION AND REACTIVATION OF DAMAGED PROTEINS

1993 • 2,177 citations

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

1998 • 1,870 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

2000 • 1,594 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses

2004 • 1,164 citations

Chemistry, Biochemistry, and Safety of Acrylamide. A Review

2003 • 1,115 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

1993 • 879 citations

An innate sense of danger

1998 • 752 citations

Stress proteins in biology and medicine

1990 • 731 citations

The mystery of nonclassical protein secretion

2003 • 583 citations

Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness

2004 • 557 citations

Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System

1999 • 474 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Selective release from cultured mammalian cells of heat‐shock (stress) proteins that resemble glia‐axon transfer proteins

1989 • 389 citations

Heat Shock Protein 70 Induced During Tumor Cell Killing Induces Th1 Cytokines and Targets Immature Dendritic Cell Precursors to Enhance Antigen Uptake

1999 • 332 citations

In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance

2001 • 317 citations

Exercise increases serum Hsp72 in humans

2001 • 281 citations

Stress proteins in biology and medicine

1990 • 273 citations

1 The Stress Response, Function of the Proteins, and Perspectives

1990 • 271 citations

Primary Tumor Tissue Lysates Are Enriched in Heat Shock Proteins and Induce the Maturation of Human Dendritic Cells

2001 • 260 citations

Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system

2003 • 215 citations

Exercise induces hepatosplanchnic release of heat shock protein 72 in humans

2002 • 184 citations

Molecular chaperone function of mammalian Hsp70 and Hsp40-a review

2000 • 170 citations

HSF1 granules: a novel stress-induced nuclear compartment of human cells

1997 • 162 citations

Heat shock proteins: the fountainhead of innate and adaptive immune responses

2000 • 134 citations

Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells

2003 • 113 citations

A stress-inducible 40 kDa protein (hsp40): purification by modified two-dimensional gel electrophoresis and co-localization with hsc70(p73) in heat-shocked HeLa cells

1993 • 102 citations

Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-γ production in T cells

2001 • 100 citations

Paeoniflorin, a novel heat shock protein–inducing compound

2004 • 98 citations

Cell surface expression of heat shock protein gp96 enhances cross-presentation of cellular antigens and the generation of tumor-specific T cell memory.

2003 • 82 citations

Intracellular Localization and Partial Amino Acid Sequence of a Stress-Inducible 40-kDa Protein in HeLa Cells.

1992 • 72 citations

Activation of Heat Shock Gene Transcription by Heat Shock Factor 1 Involves Oligomerization, Acquisition of DNA-Binding Activity, and Nuclear Localization and Can Occur in the Absence of Stress

1993 • 49 citations

Characterization of HSE sequences in human Hsp40 gene: structural and promoter analysis

1998 • 31 citations