Localized Hyperthermia Combined with Intratumoral Dendritic Cells Induces Systemic Antitumor Immunity

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Consequences of Cell Death

2000 • 1,382 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

Placebo-Controlled Phase III Trial of Immunologic Therapy with Sipuleucel-T (APC8015) in Patients with Metastatic, Asymptomatic Hormone Refractory Prostate Cancer

2006 • 1,069 citations

Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses

2002 • 845 citations

Distinct patterns and kinetics of chemokine production regulate dendritic cell function

1999 • 692 citations

Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World

1998 • 560 citations

The current and potential role of hyperthermia in radiotherapy

1989 • 505 citations

Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer.

1999 • 468 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene.

2000 • 354 citations

Vaccination With Irradiated, Autologous Melanoma Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor by Adenoviral-Mediated Gene Transfer Augments Antitumor Immunity in Patients With Metastatic Melanoma

2003 • 306 citations

Immunotherapy of cancer with dendritic-cell-based vaccines

1998 • 298 citations

Vaccination With Irradiated Autologous Tumor Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor Augments Antitumor Immunity in Some Patients With Metastatic Non–Small-Cell Lung Carcinoma

2003 • 296 citations

Molecular Characterization of Defective Antigen Processing in Human Prostate Cancer

1995 • 240 citations

Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12.

1999 • 231 citations

Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer.

1999 • 211 citations

Isolation of Dendritic Cells

2009 • 204 citations

Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization.

2001 • 202 citations

Loss of HLA class I expression in prostate cancer: Implications for immunotherapy

1995 • 189 citations

Heat shock protein 70: role in antigen presentation and immune stimulation

2002 • 189 citations

Intratumoral Injection of Dendritic Cells Engineered to Secrete Interleukin-12 by Recombinant Adenovirus in Patients With Metastatic Gastrointestinal Carcinomas

2004 • 176 citations

Dendritic cell-based immunotherapy of prostate cancer: immune monitoring of a phase II clinical trial.

2000 • 164 citations

Heat Shock Protein Vaccines Against Cancer

1993 • 156 citations

CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes.

2000 • 148 citations

T cell-dependent antitumor immunity mediated by secondary lymphoid tissue chemokine: augmentation of dendritic cell-based immunotherapy.

2001 • 148 citations

Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer

2000 • 143 citations

Noninvasive surgery of prostate tissue by high intensity focused ultrasound: an updated report

1999 • 136 citations

Therapeutic cancer vaccines

2006 • 121 citations

Progression to androgen insensitivity in a novelin vitro mouse model for prostate cancer

1995 • 121 citations

Hyperthermia Enhances CTL Cross-Priming

2006 • 95 citations

Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate

1997 • 89 citations

Hyperthermia induces apoptosis in malignant fibrous histiocytoma cellsin vitro

1996 • 87 citations

Effect of Canarypox Virus (ALVAC)-Mediated Cytokine Expression on Murine Prostate Tumor Growth

1997 • 63 citations

Therapeutic cancer vaccines: Using unique antigens

2004 • 59 citations

Sipuleucel-T (APC8015) for prostate cancer

2006 • 54 citations

Treatment Options for Localized Prostate Cancer Based on Pretreatment Serum Prostate Specific Antigen Levels

1997 • 49 citations

Flt3L Therapy following Localized Tumor Irradiation Generates Long-Term Protective Immune Response in Metastatic Lung Cancer: Its Implication in Designing a Vaccination Strategy

2006 • 49 citations

Apoptotic, necrotic, or fused tumor cells: An equivalent source of antigen for dendritic cell loading

2006 • 46 citations

Feasibility and patient tolerance of a novel transrectal ultrasound hyperthermia system for treatment of prostate cancer

2001 • 35 citations

Transperineal radiofrequency interstitial tumor ablation (RITA) of the prostate.

1998 • 32 citations

Inhibition of Murine Prostate Tumor Growth and Activation of Immunoregulatory Cells With Recombinant Canarypox Viruses

2001 • 30 citations

Radiation- and Heat-Induced Apoptosis in PC-3 Prostate Cancer Cells

1998 • 29 citations

Recent advances in the management of the neurogenic bladder

2000 • 29 citations

Role of cell-mediated immunity in tumor eradication by hyperthermia.

1981 • 26 citations

Transurethral hot-water balloon thermoablation for benign prostatic hyperplasia: patient tolerance and pathologic findings

2000 • 22 citations

Therapeutic vaccines for prostate cancer: a review of clinical data.

2005 • 15 citations