A role for NF-κB–dependent gene transactivation in sunburn

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

NF-κB: Ten Years After

1996 • 3,008 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.

1990 • 707 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

1999 • 638 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction

1997 • 601 citations

Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice

1998 • 552 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L

1998 • 472 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

1990 • 437 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

UV-induced reactive oxygen species in photocarcinogenesis and photoaging.

1997 • 402 citations

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.

1983 • 400 citations

Regulation of Gene Expression with Double-Stranded Phosphorothioate Oligonucleotides

1990 • 373 citations

Mechanisms of Ultraviolet Light‐Induced Pigmentation

1996 • 349 citations

IκBα Deficiency Results in a Sustained NF-κB Response and Severe Widespread Dermatitis in Mice

1996 • 347 citations

A survey of transformation markers in differentiating epidermal cell lines in culture.

1980 • 320 citations

Activation of human B cells by phosphorothioate oligodeoxynucleotides.

1996 • 292 citations

DNA damage enhances melanogenesis.

1996 • 284 citations

Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy

1997 • 280 citations

Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase

1998 • 228 citations

Ultraviolet Light Induces Increased Circulating Interleukin-6 in Humans

1990 • 222 citations

Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene

1996 • 217 citations

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

1997 • 217 citations

Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for a p53-mediated mammalian SOS response

1997 • 210 citations

Genomic Organization of Human and Mouse Genes for Vascular Endothelial Growth Factor C

1997 • 205 citations

The Effect of In Vitro and In Vivo UV Irradiation on the Production of ETAF Activity by Human and Murine Keratinocytes

1983 • 166 citations

UVB Light Induces Nuclear Factor κB (NFκB) Activity Independently from Chromosomal DNA Damage in Cell-Free Cytosolic Extracts

1994 • 165 citations

Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells

1999 • 159 citations

Ultraviolet B and H2O2 Are Potent Inducers of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes

1996 • 159 citations

Successive generation of antigen-presenting, dendritic cell lines from murine epidermis.

1995 • 156 citations

Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions.

1995 • 151 citations

Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice.

1996 • 147 citations

The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored byin vitrophotorepair of cyclobutane pyrimidine dimers

1997 • 144 citations

Molecular Regulation of UVB-Induced Cutaneous Angiogenesis

1998 • 141 citations

DETECTION OF CYCLOBUTANE THYMINE DIMERS IN DNA OF HUMAN CELLS WITH MONOCLONAL ANTIBODIES RAISED AGAINST A THYMINE DIMER‐ CONTAINING TETRANUCLEOTIDE

1988 • 140 citations

DNA damage enhances melanogenesis

1996 • 139 citations

Sunscreens and T4N5 Liposomes Differ in Their Ability to Protect Against Ultraviolet-Induced Sunburn Cell Formation, Alterations of Dendritic Epidermal Cells, and Local Suppression of Contact Hypersensitivity

1995 • 132 citations

Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1

1993 • 120 citations

Involvement of Cytokines, DNA Damage, and Reactive Oxygen Intermediates in Ultraviolet Radiation-Induced Modulation of Intercellular Adhesion Molecule-1 Expression

1995 • 119 citations

Intratumoral injection of oligonucleotides to the NFκB binding site inhibits cachexia in a mouse tumor model

1999 • 119 citations

Impact of UVB Radiation on the Epidermal Cytokine Network

1996 • 117 citations

Immune Recognition of Foreign DNA

1999 • 116 citations

Oligodeoxynucleotides containing palindrome sequences with internal 5'-CpG-3' act directly on human NK and activated T cells to induce IFN-gamma production in vitro.

1999 • 115 citations

Oligonucleotide Adjuvants for T Helper 1 (Th1)–specific Vaccination

1997 • 109 citations

Quantitative analysis of the immunopotency of genetically transfected dendritic cells

1998 • 94 citations

Effects of physicochemical agents on murine epidermal Langerhans cells and Thy-1-positive dendritic epidermal cells.

1986 • 90 citations

Oligodeoxynucleotides Containing Palindrome Sequences with Internal 5′-CpG-3′ Act Directly on Human NK and Activated T Cells to Induce IFN-γ Production In Vitro

1999 • 84 citations

c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.

1996 • 81 citations

Decoy Administration of NF-κB into the Subarachnoid Space for Cerebral Angiopathy

1998 • 73 citations

T cell-mediated terminal maturation of dendritic cells: loss of adhesive and phagocytotic capacities.

1996 • 73 citations

PHOTOBIOLOGY SCHOOL

1990 • 72 citations

DNA double strand breaks in epidermal cells cause immune suppression in vivo and cytokine production in vitro.

1996 • 50 citations

Ultraviolet B radiation sensitizes a murine epidermal dendritic cell line (XS52) to undergo apoptosis upon antigen presentation to T cells.

1996 • 36 citations

In vivo activation of mouse dendritic epidermal T cells in sites of contact dermatitis

1993 • 29 citations

Ibuprofen in the Treatment of UV-B-Induced Inflammation

1985 • 11 citations

Darwin deal marks growth of link-ups for gene companies

1994 • 6 citations