Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

1998 • 3,973 citations

From motivation to action: Functional interface between the limbic system and the motor system

1980 • 2,292 citations

Specificity in the projection patterns of accumbal core and shell in the rat

1991 • 1,186 citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

1996 • 1,083 citations

Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis

1988 • 619 citations

Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area

1994 • 524 citations

Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis

1989 • 386 citations

Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal

1990 • 317 citations

Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment

1991 • 282 citations

The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence

2000 • 235 citations

Conditioned taste aversions and drugs of abuse: A reinterpretation.

1997 • 233 citations

Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.

2000 • 213 citations

A small, removable microdialysis probe

1986 • 210 citations

Nicotine and food induced dopamine release in the nucleus accumbens of the rat: Putative role of α7 nicotinic receptors in the ventral tegmental area

1998 • 203 citations

Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome

1998 • 201 citations

Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis

1989 • 193 citations

Pharmacologic characterization of nicotine-induced conditioned place preference

1985 • 191 citations

The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat

1994 • 168 citations

The distribution and compartmental organization of the cholinergic neurons in nucleus accumbens of the rat

1989 • 157 citations

Effects of local and repeated systemic administration of (−)nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine, and serotonin in rat cortex

1995 • 154 citations

Nicotine-induced place preferences following prior nicotine exposure in rats

1994 • 154 citations

Effects of Feeding and Drinking on Acetylcholine Release in the Nucleus Accumbens, Striatum, and Hippocampus of Freely Behaving Rats

1992 • 150 citations

Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal

1989 • 145 citations

Systemic nicotine stimulates dopamine release in nucleus accumbens: re-evaluation of the role of N-methyl-D-aspartate receptors in the ventral tegmental area.

2000 • 135 citations

Behavioral manifestations of the nicotine abstinence syndrome in the rat: peripheral versus central mechanisms

1997 • 121 citations

Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats

1991 • 110 citations

Behavioral and Biochemical Manifestations of Mecamylamine-Precipitated Nicotine Withdrawal in the Rat Role of Nicotinic Receptors in the Ventral Tegmental Area

1999 • 102 citations

Aversion instead of preference learning indicated by nicotine place conditioning in rats

1990 • 98 citations

Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus

1995 • 97 citations

Characteristics of conditioned taste aversion produced by nicotine in rats

1983 • 90 citations

Neural systems for reinforcement and inhibition of behavior: Relevance to eating, addiction, and depression.

1999 • 83 citations

Morphine and naloxone, IP or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex

1996 • 81 citations

Microdialysis evidence that acetylcholine in the nucleus accumhens is involved in morphine withdrawal and its treatment with clonidine

1991 • 77 citations

Pharmacological characterization of nicotinic receptor-mediated acetylcholine release in rat brain—an in vivo microdialysis study

1998 • 71 citations

Modulation of opioidergic system on mecamylamine-precipitated nicotine-withdrawal aversion in rats

2000 • 63 citations

Chronic morphine induces long-lasting changes in acetylcholine release in rat nucleus accumbens core and shell: an in vivo microdialysis study

1999 • 54 citations

Neurotransmitters extraction by local intracerebral dialysis in anesthetized rats

1983 • 45 citations

Substance P decreases extracellular concentrations of acetylcholine in neostriatum and nucleus accumbens in vivo: Possible relevance for the central processing of reward and aversion

1994 • 45 citations

A microdialysis study of the effects of the nicotinic agonist RJR-2403 on cortical release of acetylcholine and biogenic amines

1996 • 42 citations

Effects of Nicotine and Footshock Stress on Dopamine Release in the Striatum and Nucleus Accumbens

1998 • 39 citations

Pharmacological characterization of nicotine‐induced acetylcholine release in the rat hippocampus in vivo: evidence for a permissive dopamine synapse

1999 • 38 citations

Aversive hypothalamic stimulation releases acetylcholine in the nucleus accumbens, and stimulation-escape decreases it

2001 • 35 citations

Different effects of scopolamine on extracellular acetylcholine levels in neostriatum and nucleus accumbens measured in vivo: possible interaction with aversive stimulation

1994 • 28 citations

Supraadditive Effect of d-Fenfluramine Plus Phentermine on Extracellular Acetylcholine in the Nucleus Accumbens

2000 • 24 citations

Previous experience of withdrawal from chronic diazepam ameliorates the aversiveness of precipitated withdrawal and reduces withdrawal‐induced c‐fos expression in nucleus accumbens

2000 • 19 citations

Deleted Work

1955 • 0 citations