The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat

Smoking withdrawal symptoms in two weeks of abstinence

1976 • 551 citations

The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

1983 • 457 citations

Symptoms of Tobacco Withdrawal

1991 • 449 citations

Rodent model of nicotine abstinence syndrome

1992 • 326 citations

Characterization of nicotine binding in mouse brain and comparison with the binding of alpha-bungarotoxin and quinuclidinyl benzilate.

1982 • 305 citations

Quantitative aspects of precipitated abstinence in morphine-dependent rats.

1973 • 252 citations

Nicotine-induced antinociception in rats and mice: correlation with nicotine brain levels.

1982 • 171 citations

Neuroendocrine reactivity to nicotine in smokers

1983 • 162 citations

Naloxone precipitates nicotine abstinence syndrome in the rat

1993 • 147 citations

Nicotine protects against μ-opioid receptor antagonism by β-funaltrexamine: Evidence for nicotine-induced release of endogenous opioids in brain

1990 • 146 citations

Nicotine and the central nervous system: Biobehavioral effects of cigarette smoking

1992 • 140 citations

Effects of the nicotinic receptor blocker mecamylamine on radial-arm maze performance in rats

1987 • 112 citations

Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats

1987 • 100 citations

What is the nature of mecamylamine's antagonism of the central effects of nicotine?

1989 • 92 citations

EEG Changes During Tobacco Withdrawal

1983 • 91 citations

Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms

1983 • 86 citations

Mecamylamine increases nicotine preference and attenuates nicotine discrimination

1989 • 83 citations

Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity

1993 • 82 citations

Neuroregulatory effects of nicotine

1989 • 82 citations

Nicotine-induced alterations in brain regional concentrations of native and cryptic Met- and Leu-enkephalin

1987 • 76 citations

[3H]mecamylamine binding to rat brain membranes

1990 • 57 citations

Effects of nicotine on fixed-interval behavior and their modification by cholinergic antagonists.

1970 • 48 citations

Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine.

1990 • 47 citations

Evidence for a behavioral deficit during withdrawal from chronic nicotine treatment

1989 • 44 citations

Biphasic effects of chronic nicotine treatment on hypothalamic immunoreactive β-endorphin in the mouse

1985 • 42 citations

Auricular microelectrostimulation: Naloxone-reversible attenuation of opiate abstinence syndrome

1988 • 42 citations

Changes in body temperature produced by cholinomimetic substances injected into the cerebral ventricles of unanaesthetized cats

1972 • 40 citations

Nicotine dependence in rats

1989 • 37 citations

Characterization of a dose—response curve for nicotine-induced conditioned taste aversion in rats: Relationship to elevation of plasma β-endorphin concentration

1990 • 35 citations

Investigations on the CNS sites of action of the discriminative stimulus effects of arecoline and nicotine

1981 • 33 citations

Plasma enkephalin-like peptide response to chronic nicotine infusion in guinea pig

1987 • 27 citations

An analysis of nicotinic and opioid processes in the medulla oblongata and nucleus ambiguus of the dog.

1983 • 26 citations

Nicotine-induced tail-tremor and drug effects

1989 • 22 citations

NICOTINE INDUCED TREMOR AND ANTIDIURESIS AND BRAIN NICOTINE LEVELS IN RATS

1977 • 16 citations