Microdialysis evidence that acetylcholine in the nucleus accumhens is involved in morphine withdrawal and its treatment with clonidine

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Time‐dose relationships for locomotor activity effects of morphine after acute or repeated treatment

1972 • 439 citations

Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal

1990 • 317 citations

Opiate reward: Sites and substrates

1989 • 291 citations

κ and δ-opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release

1984 • 275 citations

Regulation of endogenous acetylcholine release from mammalian brain slices by opiate receptors: Hippocampus, striatum and cerebral cortex of guinea-pig and rat

1989 • 115 citations

Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats

1991 • 110 citations

Long-term sensitization to the excitatory effects of morphine

1983 • 92 citations

An analysis at synaptic level of the morphine action in striatum and N. accumbens: Dopamine and acetylcholine interactions

1975 • 73 citations

Inhibition by morphine of the release of [14C]acetylcholine from rat brain cortex slices

1969 • 63 citations

MODIFICATION OF BRAIN ACETYLCHOLINE RELEASE BY MORPHINE AND ITS ANTAGONISTS IN NORMAL AND MORPHINE‐DEPENDENT RATS

1974 • 54 citations

Nalorphine-induced abstinence syndrome in morphine-tolerant albino rats.

1956 • 51 citations

Brain acetylcholine and choline following acute and chronic morphine treatment and during withdrawal.

1975 • 29 citations

Chronic morphine-induced hyperactivity in rats is altered by nucleus accumbens and ventral tegmental lesions

1984 • 28 citations

Cortical acetylcholine release is increased and γ‐aminobutyric acid outflow is reduced during morphine withdrawal

1986 • 27 citations

Brain acetylcholine during morphine withdrawal

1984 • 23 citations

Microdialysis in the Study of Psychostimulants and the Neural Substrate for Reinforcement: Focus on Dopamine and Serotonin

1992 • 17 citations

Activation of locus coeruleus neurons in the rat by a benzazocine derivative (UM 1046) that mimics opiate withdrawal

1983 • 13 citations

The opiate quasiwithdrawal syndrome in rhesus monkeys: Comparison of naloxone-precipitated withdrawal to effects of cholinergic agents

1984 • 11 citations

Changes in cortical acetylcholine and gamma-aminobutyric acid outflow during morphine withdrawal involve alpha-1 and alpha-2 receptors.

1989 • 8 citations