Behavioral manifestations of the nicotine abstinence syndrome in the rat: peripheral versus central mechanisms

Induction of physical dependence upon ethanol and the associated behavioral changes in rats

1975 • 740 citations

Smoking withdrawal symptoms in two weeks of abstinence

1976 • 551 citations

Tolerance to and physical dependence on morphine in rats

1963 • 446 citations

Ethanol withdrawal seizures and the NMDA receptor complex

1990 • 444 citations

Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain: putative implications for psychiatry and psychopharmacology

1987 • 342 citations

Rodent model of nicotine abstinence syndrome

1992 • 326 citations

Characterization of the locomotor stimulant action of nicotine in tolerant rats

1983 • 222 citations

Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol

1974 • 195 citations

Desensitization of the nicotine‐induced mesolimbic dopamine responses during constant infusion with nicotine

1995 • 168 citations

The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat

1994 • 168 citations

Condition-independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat

1996 • 157 citations

Nicotine and smoking: a perspective from animal studies

1987 • 151 citations

Naloxone precipitates nicotine abstinence syndrome in the rat

1993 • 147 citations

Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats

1987 • 100 citations

Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion‐blocking drug chlorisondamine

1984 • 62 citations

Peripheral induction of burst firing in locus coeruleus neurons by nicotine mediated via excitatory amino acids

1989 • 53 citations

Regulation of nicotinic receptors in rat brain following quasi‐irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine

1994 • 50 citations

Evidence for a behavioral deficit during withdrawal from chronic nicotine treatment

1989 • 44 citations

Nicotinic receptor blockade therapy and smoking cessation

1991 • 35 citations

Nicotine-induced activation of locus coeruleus neurons —an analysis of peripheral versus central induction

1994 • 31 citations