T and B cell Tolerance and Responses to Viral Antigens in Transgenic Mice: Implications for the Pathogenesis of Autoimmune versus Immunopathological Disease

Towards a network theory of the immune system.

1974 • 3,379 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

The cytokine network

1989 • 785 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

The Relation Between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides

1987 • 696 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

1990 • 578 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

The Virology and Immunobiology of Lymphocytic Choriomeningitis Virus Infection

1980 • 554 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes.

1985 • 526 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

The Biology and Detection of Immune Complexes

1980 • 463 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen

1983 • 422 citations

Nucleotide sequences of the mRNA's encoding the vesicular stomatitis virus G and M proteins determined from cDNA clones containing the complete coding regions

1981 • 404 citations

Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments.

1983 • 363 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

A maternally inherited superantigen encoded by a mammary tumour virus

1991 • 335 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

The carrier effect in the secondary response to hapten‐protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis

1971 • 319 citations

The Biology of Lymphocytic Choriomeningitis Infection: Virus-induced Immune Disease

1962 • 309 citations

Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice

1991 • 307 citations

Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes

1991 • 297 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo

1984 • 296 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

T‐Cell‐Mediated Immunopathology in Viral Infections

1974 • 287 citations

The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus I. Analysis of neutralizing epitopes with monoclonal antibodies

1982 • 284 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

Immunological Unresponsiveness

1973 • 278 citations

An endogenous retrovirus mediating deletion of αβ T cells?

1991 • 278 citations

Vaccinia Virus Expression Vectors

1987 • 272 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

1988 • 266 citations

Antigen presenting function of class II MHC expressing pancreatic beta cells

1988 • 255 citations

A Disquisition on Suppressor T Cells

1975 • 255 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Cell Interactions Between Histoincompatible T and B Lymphocytes. The H-2 Gene Complex Determines Successful Physiologic Lymphocyte Interactions

1973 • 241 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Recombinant vaccinia virus primes and stimulates influenza haemagglutinin-specific cytotoxic T cells

1984 • 234 citations

Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin.

1983 • 225 citations

The Glycoprotein of Vesicular Stomatitis Virus Is the Antigen That Gives Rise to and Reacts with Neutralizing Antibody

1972 • 221 citations

The Origin and Mechanism of the Allograft Reaction

1977 • 217 citations

T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?

1986 • 210 citations

T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses

1988 • 205 citations

Do Suppressor T Cells Exist?

1988 • 201 citations

Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations.

1985 • 196 citations

An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it

1980 • 190 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.

1976 • 173 citations

STUDIES ON CELL-MEDIATED IMMUNITY TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN MICE

1973 • 167 citations

MHC-Linked Protection from Diabetes Dissociated from Clonal Deletion of T Cells

1990 • 167 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes.

1988 • 166 citations

Activation of Transplant Immunity: Effect of Donor Leukocytes on Thyroid Allograft Rejection

1976 • 159 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.

1989 • 156 citations

Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus

1988 • 155 citations

The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

1991 • 147 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Thymus dependence of viral antigens

1975 • 145 citations

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

1980 • 139 citations

Limit of T Cell Tolerance to Self Proteins by Peptide Presentation

1990 • 138 citations

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

1990 • 136 citations

NONANTIGENICITY AND IMMUNOLOGIC TOLERANCE: THE ROLE OF THE CARRIER IN THE INDUCTION OF TOLERANCE TO THE HAPTEN

1971 • 135 citations

T- and B-cell recognition of hepatitis B viral antigens

1988 • 130 citations

Virus-induced autoantibody response to a transgenic viral antigen

1990 • 130 citations

Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus

1988 • 125 citations

Anti‐viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia‐recombinant virus expressing LCMV‐WE nucleoprotein or glycoprotein

1989 • 123 citations

Experimental Allergic Encephalomyelitis in the Rat: Response to Encephalitogenic Proteins and Peptides

1973 • 122 citations

Recognition of cloned vesicular stomatitis virus internal and external gene products by cytotoxic T lymphocytes.

1986 • 122 citations

T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis

1989 • 121 citations

Recognition of influenza A matrix protein by HLA-A2-restricted cytotoxic T lymphocytes. Use of analogues to orientate the matrix peptide in the HLA-A2 binding site.

1988 • 121 citations

Regulatory Mechanisms in the Immune Response to Cell-surface Antigens

1977 • 118 citations

Thymocyte rosettes: multicellular complexes of lymphocytes and bone marrow-derived stromal cells in the mouse thymus.

1982 • 114 citations

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent.

1991 • 108 citations

Immunofluorescence study of the carrier state and mechanism of vertical transmission in lymphocytic choriomeningitis virus infection in mice

1966 • 106 citations

Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.

1989 • 104 citations

Intrathymic presentation of circulating non-major histocompatibility complex antigens

1984 • 102 citations

H-2 Compatibility Requirement for Virus-Specific T Cell-Mediated Effector Functions in Vivo

1976 • 99 citations

Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

1990 • 92 citations

Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides.

1990 • 91 citations

Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens.

1981 • 90 citations

Functional clonal deletion of class I-specific cytotoxic T lymphocytes by veto cells that express antigen.

1984 • 90 citations

The veto phenomenon and T-cell regulation

1986 • 81 citations

The expression of influenza virus hemagglutinin in the pancreatic β cells of transgenic mice results in autoimmune diabetes

1990 • 79 citations

Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections.

1982 • 77 citations

A natural model of immunologic tolerance. Tolerance to murine C5 is mediated by T cells, and antigen is required to maintain unresponsiveness.

1982 • 74 citations

The immune response of the mouse to lymphocytic choriomeningitis virus V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection

1987 • 72 citations

Lipopolysaccharide induces C-type virus in short term cultures of BALB/c spleen cells

1975 • 66 citations

An antigenic analysis ofPasteurella pestisby diffusion of antigens and antibodies in agar

1956 • 63 citations

Speculations on Mechanisms of HLA Associations with Autoimmune Diseases and the Specificity of “Autoreactive” T Lymphocytes

1990 • 61 citations

Impaired Generation of Anti‐Viral Cytotoxicity against Lymphocytic Choriomeningitis and Vaccinia Virus in Mice Treated with CD4‐Specific Monoclonal Antibody

1989 • 56 citations

Characterization of virus‐specific cytotoxic T cell clones from allogeneic bone marrow chimeras

1987 • 56 citations

Analysis of the kinetics of antiviral memory T help in vivo: characterization of short‐lived cross‐reactive T help

1990 • 55 citations

Hypothesis: A model for generalised autoimmunity

1973 • 54 citations

Coxsackievirus-B3-induced myocarditis: virus receptor antibodies modulate myocarditis.

1989 • 53 citations

T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones.

1990 • 52 citations

Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen.

1987 • 51 citations

STUDIES ON IMMUNOLOGICAL TOLERANCE TO LCM VIRUS

1965 • 50 citations

Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model.

1986 • 50 citations

Cross-reactive cytotoxic T cells to serologically distinct vesicular stomatitis virus.

1980 • 47 citations

CELLULAR EVENTS DURING THE INDUCTION OF EXPERIMENTAL THYROIDITIS IN THE RABBIT

1972 • 44 citations

Transgenic mice expressing a soluble foreign H-2 class I antigen are tolerant to allogeneic fragments presented by self class I but not to the whole membrane-bound alloantigen.

1990 • 44 citations

Serological Characterization of the Three Major Proteins of Vesicular Stomatitis Virus

1974 • 42 citations

Self-reactive T cells can escape clonal deletion in T-cell receptor V beta 8.1 transgenic mice.

1990 • 41 citations

Peripheral tolerance in mice expressing a liver-specific class I molecule: inactivation/deletion of a T-cell subpopulation.

1990 • 40 citations

Antigen Presentation by B Lymphocytes: A Critical Step in T-B Collaboration

1986 • 32 citations

Idiotypic Regulation of T Cells in Graft‐Versus‐Host Disease and Autoimmunity

1989 • 30 citations

Antiviral T-Cell Memory?

1990 • 30 citations

The specificity of acquired immunological tolerance to azo proteins.

1958 • 28 citations

Does the presence of self-reactive T cells indicate the breakdown of tolerance?

1990 • 22 citations

Determinants of the B-cell response against a transgenic autoantigen.

1990 • 22 citations

Non‐tolerance and differential susceptibility to diabetes in transgenic mice expressing major histocompatibility class II genes on pancreatic β cells

1990 • 21 citations

Mimicry by Virus of Host Molecules: Implications for Autoimmune Disease

1986 • 19 citations

Partial tolerance in β‐galactosidase‐transgenic mice

1990 • 16 citations

Immunopathologic alterations of lymphatic tissues of mice infected with lymphocytic choriomeningitis virus. I. Histopathologic findings.

1981 • 15 citations

Neonatal exposure to immunogenic peptides. Differential susceptibility to tolerance induction of helper T cells and B cells reactive to malarial circumsporozoite peptide epitopes.

1988 • 14 citations

Antigen-presenting B cells: Efficient uptake and presentation by activated B cells for induction of cytotoxic T lymphocytes against vesicular stomatitis virus

1988 • 14 citations

Mother-Infant Interaction in Lymphocytic Choriomeningitis Virus Infection of the Newborn Mouse: The Effect of Maternal Health on Mortality of Offspring

1970 • 10 citations

Autoimmunity in the Nervous System: Functional Properties of an Encephalitogenic Protein

1989 • 10 citations

The Effects of carrier-specific helper T-cell tolerance on antibody avidity in the anti-hapten response

1976 • 7 citations

Central versus peripheral tolerance: clonal inactivation versus suppressor T cells, the second half of the 'Thirty Years War'.

1989 • 7 citations

How to escape immune surveillance?

1982 • 5 citations

Immunological Tolerance to Many Self Epitopes may be Unnecessary

1990 • 5 citations