Autoimmunity, microbial immunity and the immunological homunculus

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation

1971 • 677 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

1990 • 605 citations

Cardiac myosin induces myocarditis in genetically predisposed mice.

1987 • 507 citations

Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.

1989 • 492 citations

Stress proteins are immune targets in leprosy and tuberculosis.

1988 • 446 citations

Anti-Idiotypic Network Induced by T Cell Vaccination Against Experimental Autoimmune Encephalomyelitis

1988 • 409 citations

The clonal selection theory of acquired immunity

1960 • 396 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Chlamydial disease pathogenesis. The 57-kD chlamydial hypersensitivity antigen is a stress response protein.

1989 • 334 citations

Antibodies to two major chicken heat shock proteins cross-react with similar proteins in widely divergent species.

1982 • 316 citations

SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITIS

1988 • 311 citations

Normal, Autoimmune, and Malignant CD5+ B Cells: The LY-1 B Lineage?

1988 • 302 citations

The Mycobacterium tuberculosis 65-kilodalton antigen is a heat shock protein which corresponds to common antigen and to the Escherichia coli GroEL protein

1988 • 297 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Stress proteins may provide a link between the immune response to infection and autoimmunity

1989 • 264 citations

A role for heat shock proteins in inflammation?

1988 • 262 citations

Molecular cloning of a protective antigen of schistosomes

1987 • 245 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

A heat shock operon in Coxiella burnetti produces a major antigen homologous to a protein in both mycobacteria and Escherichia coli

1988 • 198 citations

Control of Experimental Autoimmune Encephalomyelitis by T Cells Responding to Activated T Cells

1989 • 197 citations

The major parasite surface antigen associated with human resistance to schistosomiasis is a 37-kD glyceraldehyde-3P-dehydrogenase.

1989 • 188 citations

Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus.

1988 • 186 citations

Immunochemical characterization of and isolation of the gene for a Borrelia burgdorferi immunodominant 60-kilodalton antigen common to a wide range of bacteria

1988 • 178 citations

The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni.

1988 • 177 citations

Primary structures of Sm31/32 diagnostic proteins of Schistosoma mansoni and their identification as proteases

1989 • 161 citations

Autoantibodies to the heat-shock protein hsp90 in systemic lupus erythematosus.

1988 • 158 citations

Immunological Aspects of Leprosy � Present Status

2015 • 138 citations

T Cell Receptors in Murine Autoimmune Diseases

1989 • 137 citations

Natural autoantibodies might prevent autoimmune disease

1986 • 136 citations

The Genome of Trypanosoma cruzi Contains a Constitutively Expressed, Tandemly Arranged Multicopy Gene Homologous to a Major Heat Shock Protein

1987 • 129 citations

The T-Cell Receptor Repertoire and Autoimmune Diseases

1989 • 124 citations

A major immunogen in Schistosoma mansoni infections is homologous to the heat-shock protein Hsp70.

1987 • 120 citations

Homology of the 70-kilodalton antigens from Mycobacterium leprae and Mycobacterium bovis with the Mycobacterium tuberculosis 71-kilodalton antigen and with the conserved heat shock protein 70 of eucaryotes

1989 • 114 citations

The Self, the World and Autoimmunity

1988 • 112 citations

Sequence and expression of a major egg antigen from Schistosoma mansoni. Homologies to heat shock proteins and alpha-crystallins

1986 • 112 citations

A 75 kd merozoite surface protein of Plasmodium falciparum which is related to the 70 kd heat-shock proteins.

1987 • 104 citations

Molecular cloning of mtp70, a mitochondrial member of the hsp70 family.

1989 • 97 citations

Orientation of epitopes influences the immunogenicity of synthetic peptide dimmers

1988 • 91 citations

The role of anti‐idiotypic antibodies in the induction of experimental systemic lupus erythematosus in mice

1989 • 87 citations

The genome of Trypanosoma cruzi contains a constitutively expressed, tandemly arranged multicopy gene homologous to a major heat shock protein.

1987 • 87 citations

Aldolase Activity of a Plasmodium falciparum Protein with Protective Properties

1988 • 83 citations

Heat shock cognate 70 is a prominent immunogen in Brugian filariasis.

1989 • 83 citations

Cloning and temperature-dependent expression in Escherichia coli of a Legionella pneumophila gene coding for a genus-common 60-kilodalton antigen

1989 • 83 citations

The 75-kilodalton protein of Chlamydia trachomatis: a member of the heat shock protein 70 family?

1990 • 80 citations

A heat shock‐like protein from the human malaria parasite plasmodium falciparum induces autoantibodies

1989 • 80 citations

Theories of Immune Networks

1989 • 79 citations

Schistosome heat-shock proteins are immunologically distinct host-like antigens

1988 • 72 citations

A protein antigen of Mycobacterium leprae is related to a family of small heat shock proteins

1988 • 68 citations

Amino acid sequence homology between cyclophilin and a cDNA-cloned antigen of Echinococcus granulosus

1989 • 61 citations

Onchocerca volvulus heat shock protein 70 is a major immunogen in amicrofilaremic individuals from a filariasis-endemic area

1989 • 60 citations

A major antigen from Mycobacterium tuberculosis which is homologous to the heat shock proteins groES from E.coli and the htpA gene product of Coxiella burneti

1988 • 58 citations

Chaperonins and the immune response.

1990 • 57 citations

V-Region Connectivity in T Cell Repertoires

1989 • 54 citations

Network regulation of autoimmunity: An automaton model

1989 • 53 citations

Cloning and Expression of Treponema pallidum Common Antigen (Tp-4) in Escherichia coli K12

1987 • 52 citations

Tolerize one, tolerize them all: tolerance is self-assertion

1989 • 44 citations

Perspectives on Autoimmunity

1989 • 41 citations

The 86-kilodalton antigen from Schistosoma mansoni is a heat-shock protein homologous to yeast HSP-90

1989 • 37 citations

Molecular cloning of Schistosoma mansoni myosin

1987 • 36 citations

APlasmodium falciparumgene encoding a heat shock-like antigen related to the rat 78 Kd glucose-regulated protein

1988 • 32 citations

Identification of a heat shock-like antigen in P.falciparum, related to the heat shock protein 90 family

1988 • 29 citations

The mosaic of autoimmunity : (the factors associated with autoimmune disease )

1989 • 23 citations

Acetylcholine Receptor Antibodies and Anti‐Idiotype Antibodies Produced in Blood Lymphocyte Cultures from Patients with Myasthenia Gravis

1986 • 21 citations

Autoantibodies directed against heart antigens and endocrine reactivity in patients with recent myocardial infarction

1973 • 17 citations

Nucleotide and deduced amino acid sequence ofMycobacterium lepraemanganese superoxide dismutase

1989 • 16 citations

The Mosaic of Autoimmunity. The Factors Associated with Autoimmune Disease

1990 • 12 citations

Characterization of a Leishmania donovani antigen similar to heat shock protein 70

1989 • 4 citations

[20] Production and properties of anti-idiotypic antibodies that recognize insulin receptor

1989 • 1 citations