Self Tolerance in the B‐Cell Repertoire

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Genes and Antibodies

1959 • 675 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells

1971 • 374 citations

Studies on the capacity of B cells to serve as antigen-presenting cells.

1981 • 349 citations

The Dynamic Nature of the Antibody Repertoire

1988 • 321 citations

The Role of Somatic Hypermutation in the Generation of Antibody Diversity

1989 • 305 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.

1989 • 245 citations

Murine Natural Monoclonal Autoantibodies: A Study of their Polyspecificities and their Affinities

1986 • 215 citations

Induction of Self-Rolerance in T Cells But Not B Cells of Transgenic Mice Expressing Little Self Antigen

1991 • 211 citations

A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

1986 • 197 citations

Can B cells turn on virgin T cells?

1988 • 192 citations

Receptor-mediated inactivation of early B lymphocytes

1975 • 187 citations

Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus.

1988 • 178 citations

The Need for Central and Peripheral Tolerance in the B Cell Repertoire

1990 • 154 citations

Antigen presentation by splenic B cells: resting B cells are ineffective, whereas activated B cells are effective accessory cells for T cell responses.

1985 • 145 citations

Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence

1983 • 133 citations

Antibody Repertoires of Normal BALB/c Mice: B Lymphocyte Populations Defined by State of Activation

1986 • 129 citations

Characterization of self-reactive B cells by polyclonal B-cell activators.

1977 • 125 citations

Modification of B Lymphocyte Differentiation by Anti-Immunoglobulins

1974 • 106 citations

Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

1990 • 92 citations

Paralysis to serum albumins in T and B lymphocytes in mice. Dose dependence, specificity and kinetics of escape

1974 • 51 citations

Immunological subsets in human B-cell lymphomas.

1981 • 47 citations

Cell surface immunoglobulin. XVIII. Functional differences of B lymphocytes bearing different surface immunoglobulin isotypes.

1976 • 46 citations

Intolerable secretion in tolerant transgenic mice

1988 • 42 citations

the relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. III. Expression of a single predominant isotype on primed and unprimed B cells

1978 • 37 citations

Clonal Silencing of Self-reactive B Lymphocytes in a Transgenic Mouse Model

1989 • 36 citations

In vivo generation and function of B cells in the presence of a monoclonal anti‐IgM antibody: implications for B cell tolerance

1987 • 29 citations

Do tolerant T cells exist?

1989 • 25 citations

A dichotomy between the expression of IgD on B cells and its requirement for triggering such cells with two T-independent antigens

1979 • 17 citations

The in vitro translation product of the murine λ 5 gene contains a functional signal peptide

1988 • 16 citations

Clonal anergy: Inhibition of antigen‐driven proliferation among single B lymphocytes from tolerant animals, and partial breakage of anergy by mitogens

1983 • 15 citations

Self-tolerance in B lymphocytes.

1989 • 14 citations

Irreversible Receptor Modulation on B Lymphocytes and the Control of Antibody‐Forming Cells by Antigen

1979 • 11 citations

Activation events in hapten-specific B cells from tolerant mice.

1988 • 10 citations