New Potential Agents in Treating Diabetic Kidney Disease

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

1998 • 19,638 citations

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

2016 • 11,500 citations

Biochemistry and molecular cell biology of diabetic complications

2001 • 8,707 citations

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.

1998 • 8,603 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

Multifactorial Intervention and Cardiovascular Disease in Patients with Type 2 Diabetes

2003 • 4,328 citations

Dietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children

2016 • 3,967 citations

Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients.

2000 • 743 citations

Sensory Neuropathy from Pyridoxine Abuse

1983 • 695 citations

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

1997 • 532 citations

Randomized Trial of an Inhibitor of Formation of Advanced Glycation End Products in Diabetic Nephropathy

2004 • 444 citations

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

2000 • 425 citations

Protein Kinase C–Dependent Increase in Reactive Oxygen Species (ROS) Production in Vascular Tissues of Diabetes

2003 • 419 citations

Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat

2002 • 373 citations

Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

2003 • 373 citations

The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

2002 • 349 citations

Role of Advanced Glycation End Products in Diabetic Nephropathy

2003 • 344 citations

From Hyperglycemia to Diabetic Kidney Disease: The Role of Metabolic, Hemodynamic, Intracellular Factors and Growth Factors/Cytokines

2004 • 342 citations

(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ

1996 • 336 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Advanced glycation end products: A nephrologist's perspective

2000 • 293 citations

The Effect of Ruboxistaurin on Nephropathy in Type 2 Diabetes

2005 • 293 citations

Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy

1994 • 273 citations

Incidence of End-stage Renal Disease in Patients With Type 1 Diabetes

2005 • 269 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins

1995 • 246 citations

The Effect of Ruboxistaurin on Visual Loss in Patients With Moderately Severe to Very Severe Nonproliferative Diabetic Retinopathy

2005 • 209 citations

Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

2003 • 205 citations

AGEs induce oxidative stress and activate protein kinase C-β_IIin neonatal mesangial cells

2000 • 199 citations

Oral Sulodexide Reduces Albuminuria in Microalbuminuric and Macroalbuminuric Type 1 and Type 2 Diabetic Patients

2002 • 190 citations

Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage

2005 • 175 citations

The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats

2003 • 175 citations

Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders

2003 • 168 citations

Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C β-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial

2005 • 168 citations

Advanced glycation end products and the progressive course of renal disease

2001 • 160 citations

The Role of AGEs and AGE Inhibitors in Diabetic Cardiovascular Disease

2005 • 158 citations

Glycosaminoglycans prevent morphological renal alterations and albuminuria in diabetic rats

1992 • 157 citations

The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy. Initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) Multicenter Randomized Clinical Trial

2005 • 149 citations

Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α−Dependent Pathway

2004 • 148 citations

Diabetes and nephropathy

2003 • 148 citations

Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy

1994 • 138 citations

Pyridoxamine: The Many Virtues of a Maillard Reaction Inhibitor

2005 • 116 citations

Effective Antihypertensive Treatment Postpones Renal Insufficiency in Diabetic Nephropathy

1993 • 111 citations

Heparin stimulates the synthesis and modifies the sulfation pattern of heparan sulfate proteoglycan from endothelial cells

1989 • 110 citations

Heparanase-1 Gene Expression and Regulation by High Glucose in Renal Epithelial Cells

2005 • 109 citations

Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression

2005 • 108 citations

Proteomic Patterns and Prediction of Glomerulosclerosis and Its Mechanisms

2005 • 107 citations

Enhanced Expression of Receptor for Advanced Glycation End Products in Chronic Kidney Disease

2004 • 106 citations

Angiotensin II Promotes Glucose-Induced Activation of Cardiac Protein Kinase C Isozymes and Phosphorylation of Troponin I

2001 • 97 citations

The health care costs of diabetic nephropathy in the United States and the United Kingdom

2004 • 95 citations

Mechanism of Perturbation of Integrin-Mediated Cell-Matrix Interactions by Reactive Carbonyl Compounds and Its Implication for Pathogenesis of Diabetic Nephropathy

2005 • 95 citations

High expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy

2004 • 93 citations

Angiotensin-Converting Enzyme Inhibition and Renal Protection in Nondiabetic Patients

2005 • 91 citations

Protein Kinase Cβ Inhibition Attenuates Osteopontin Expression, Macrophage Recruitment, and Tubulointerstitial Injury in Advanced Experimental Diabetic Nephropathy

2005 • 89 citations

The Contribution of Increased Diabetes Prevalence and Improved Myocardial Infarction and Stroke Survival to the Increase in Treated End-Stage Renal Disease

2003 • 87 citations

Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease

2003 • 86 citations

Overview

2003 • 86 citations

Activation of the Gi Heterotrimeric G Protein by ANCA IgG F(ab′)2 Fragments Is Necessary but not Sufficient to Stimulate the Recruitment of Those Downstream Mediators Used by Intact ANCA IgG

2003 • 84 citations

A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C β inhibition

2003 • 82 citations

Glycosaminoglycans Delay the Progression of Nephropathy in NIDDM

1997 • 81 citations

Pimagedine: a novel therapy for diabetic nephropathy

2002 • 81 citations

Nitric Oxide-Mediated Regulation of Connexin43 Expression and Gap Junctional Intercellular Communication in Mesangial Cells

2004 • 80 citations

Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding

1999 • 77 citations

Early glycosilation products induce glomerular hyperfiltration in normal rats

1992 • 77 citations

Characterization of Mechanisms Involved in Secretion of Active Heparanase

2006 • 76 citations

Glycosaminoglycan Therapy Prevents TGF-β1 Overexpression and Pathologic Changes in Renal Tissue of Long-Term Diabetic Rats

2000 • 74 citations

Immunocytochemical detection of advanced glycated end products in rat renal tissue as a function of age and diabetes

1998 • 66 citations

A randomized, controlled study of sulodexide therapy for the treatment of diabetic nephropathy

1997 • 65 citations

Pharmacological Actions of Sulodexide

1998 • 64 citations

Ruboxistaurin, a Protein Kinase C β Inhibitor, as an Emerging Treatment for Diabetes Microvascular Complications

2005 • 61 citations

High concentration of glucose inhibits glomerular endothelial eNOS through a PKC mechanism

2004 • 57 citations

Selective Protein Kinase C Inhibitors and Their Applications

2003 • 57 citations

Glycosaminoglycans

2000 • 56 citations

One year course of oral sulodexide in the management of diabetic nephropathy.

2005 • 55 citations

Advanced Glycation End Products in Clinical Nephrology

2003 • 54 citations

Aminoguanidine and ramipril prevent diabetes-induced increases in protein kinase C activity in glomeruli, retina and mesenteric artery

2001 • 52 citations

Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1

2006 • 52 citations

Advanced Glycation End Products in Diabetes‐Associated Atherosclerosis and Renal Disease: Interventional Studies

2005 • 49 citations

Clinical studies of advanced glycation end product inhibitors and diabetic kidney disease

2004 • 48 citations

Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose

2001 • 47 citations

Effect of glycosaminoglycans on urinary albumin excretion in insulin-dependent diabetic patients with micro- or macroalbuminuria

1997 • 42 citations

Reaction of pyridoxamine with malondialdehyde: Mechanism of inhibition of formation of advanced lipoxidation end-products

2005 • 42 citations

Glycosaminoglycan sulodexide decreases albuminuria in diabetic patients

1997 • 41 citations

Incidence of End-Stage Renal Disease Among Persons With Diabetes—United States, 1990-2002

2005 • 39 citations

Therapy with glycosaminoglycans lowers albumin excretion rate in non insulin dependent diabetic patients with macroalbuminuria

1994 • 36 citations

Post‐Amadori AGE Inhibition as a Therapeutic Target for Diabetic Complications: A Rational Approach to Second‐Generation Amadorin Design

2005 • 36 citations

Amino acids injure mesangial cells by advanced glycation end products, oxidative stress, and protein kinase C

2005 • 35 citations

New therapies for advanced glycation end product nephrotoxicity: Current challenges

2003 • 31 citations

The next generation of diabetic nephropathy therapies: An update

2005 • 29 citations

A pilot study of the effect of the glycosaminoglycan sulodexide on microalbuminuria in type I diabetic patients

1997 • 29 citations

Aminoguanidine and ramipril prevent diabetes-induced increases in protein kinase C activity in glomeruli, retina and mesenteric artery

2001 • 29 citations

Heparin modulates proliferation and proteoglycan biosynthesis in murine mesangial cells: molecular clues for its activity in nephropathy

1995 • 24 citations

Glycosaminoglycans: a new paradigm in the prevention of proteinuria and progression of glomerular disease

1996 • 23 citations

Subject Index Vol. 11, 2000

2000 • 18 citations

The protein kinase C-β inhibitor, ruboxistaurin, for the treatment of diabetic microvascular complications

2005 • 18 citations

Glycosaminoglycans as a Possible Tool for Micro- and Macroalbuminuria in Diabetic Patients. A Pilot Study

1997 • 17 citations

IN VIVO METABOLISM OF [¹⁴C]RUBOXISTAURIN IN DOGS, MICE, AND RATS FOLLOWING ORAL ADMINISTRATION AND THE STRUCTURE DETERMINATION OF ITS METABOLITES BY LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY AND NMR SPECTROSCOPY

2005 • 14 citations

Deleted Work

1955 • 0 citations