Angiotensin II Promotes Glucose-Induced Activation of Cardiac Protein Kinase C Isozymes and Phosphorylation of Troponin I

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Some statistical methods useful in circulation research.

1980 • 3,978 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.

1998 • 460 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Angiotensin II Induces Apoptosis of Adult Ventricular MyocytesIn Vitro

1997 • 413 citations

Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy

1997 • 388 citations

A Selective ε-Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death

1997 • 386 citations

Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation

1999 • 361 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Myocyte Death in Streptozotocin-Induced Diabetes in Rats Is Angiotensin II- Dependent

2000 • 292 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Metabolic disturbances in diabetic cardiomyopathy.

1998 • 247 citations

Protein kinase C isoform expression and regulation in the developing rat heart.

1994 • 245 citations

Diabetic Cardiomyopathy: A unique entity or a complication of coronary artery disease?

1995 • 243 citations

The diabetic heart: metabolic causes for the development of a cardiomyopathy

1992 • 234 citations

Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells

1997 • 220 citations

Troponin I Switching in the Developing Heart

1989 • 212 citations

Protein Kinase C, but Not Tyrosine Kinases or Ras, Plays a Critical Role in Angiotensin II-induced Activation of Raf-1 Kinase and Extracellular Signal-regulated Protein Kinases in Cardiac Myocytes

1996 • 211 citations

Cardiotrophic Effects of Protein Kinase C ε

2000 • 199 citations

Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats.

1993 • 185 citations

Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat.

1994 • 181 citations

In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts.

1998 • 178 citations

Phosphorylation Specificities of Protein Kinase C Isozymes for Bovine Cardiac Troponin I and Troponin T and Sites within These Proteins and Regulation of Myofilament Properties

1996 • 170 citations

Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved.

1998 • 163 citations

Protein kinase C isoform diversity in the heart

1995 • 146 citations

Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes.

1997 • 145 citations

Experimental Diabetes Is Associated With Functional Activation of Protein Kinase Cε and Phosphorylation of Troponin I in the Heart, Which Are Prevented by Angiotensin II Receptor Blockade

1997 • 135 citations

Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats

1999 • 128 citations

Insulin-Like Growth Factor-1 Induces Mdm2 and Down-Regulates p53, Attenuating the Myocyte Renin-Angiotensin System and Stretch-Mediated Apoptosis

1999 • 113 citations

Responses of Cardiac Protein Kinase C Isoforms to Distinct Pathological Stimuli Are Differentially Regulated

1999 • 109 citations

The Cardiac Renin-Angiotensin System in STZ-Induced Diabetes

1994 • 106 citations

p53 phosphorylation: Biochemical and functional consequences

1996 • 104 citations

Troponin T switching in the developing rat heart.

1988 • 92 citations

Diabetic microvascular complications and growth factors

2009 • 91 citations

Protein kinase Cζ and n in murine epidermis TPA induces down‐regulation of PKCn but not PKCζ

1992 • 88 citations

Dissociation of protein kinase C redistribution from the phosphorylation of its substrates

1991 • 87 citations

Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites.

1996 • 77 citations

High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells

1995 • 75 citations

Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue.

1995 • 65 citations

Measurement of immunoreactive angiotensin peptides in rat tissues: Some pitfalls in angiotensin II analysis

1988 • 59 citations

Glucose-induced vascular smooth muscle dysfunction: the role of protein kinase C

1995 • 57 citations

Effects of Constitutive Overexpression of Insulin-Like Growth Factor-1 on the Mechanical Characteristics and Molecular Properties of Ventricular Myocytes

1998 • 55 citations

Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat

1998 • 53 citations

Protein kinase C activity is altered in diabetic rat hearts

1992 • 48 citations

Thrombin Receptor Actions in Neonatal Rat Ventricular Myocytes

1996 • 40 citations

Overexpression of core 2 N‐acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice

1999 • 27 citations

Metabolic disturbances in diabetic cardiomyopathy

1998 • 25 citations

The Role of Protein Kinase C in Ischemic Preconditioning

1996 • 23 citations

The cardiac renin-angiotensin system in STZ-induced diabetes

1994 • 23 citations