Back to search

Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C β-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial

Data up to Jan 2025

Published2005
Citations168
References75

Total Citations Per Year

Abstract

References (75)

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

1998 • 19,638 citations

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

2002 • 10,002 citations

ECDEU Assessment Manual for Psychopharmacology

1976 • 8,729 citations

The McGill Pain Questionnaire: Major properties and scoring methods

1975 • 6,706 citations

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

1997 • 6,073 citations

Multifactorial Intervention and Cardiovascular Disease in Patients with Type 2 Diabetes

2003 • 4,328 citations

WORLD MEDICAL ASSOCIATION DECLARATION OF HELSINKI: Ethical Principles for Medical Research Involving Human Subjects

2001 • 3,499 citations

World Medical Association Declaration of Helsinki

2000 • 2,287 citations

Ethical principles for medical research involving human subjects

2003 • 1,972 citations

Diabetic Neuropathies

2005 • 1,791 citations

A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population

1993 • 1,453 citations

The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population‐based cohort

1993 • 1,410 citations

Vascular Risk Factors and Diabetic Neuropathy

2005 • 1,197 citations

Diabetic Somatic Neuropathies

2004 • 908 citations

Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy

2001 • 674 citations

Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study

1996 • 674 citations

Detection, characterization, and staging of polyneuropathy: Assessed in diabetics

1988 • 549 citations

Lower-extremity amputation in diabetes. The independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers.

1999 • 505 citations

Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant ?-lipoic acid

1995 • 505 citations

Epidemiology of severe hypoglycemia in the diabetes control and complications trial

1991 • 465 citations

Risk Factors for Amputation in Patients with Diabetes Mellitus

1992 • 444 citations

[WHO Expert Committee on diabetes mellitus].

1981 • 422 citations

Longitudinal assessment of diabetic polyneuropathy using a composite score in the Rochester Diabetic Neuropathy Study cohort

1997 • 376 citations

Walking stability and sensorimotor function in older people with diabetic peripheral neuropathy

2004 • 373 citations

Epidemiological Correlates of Diabetic Neuropathy: Report From Pittsburgh Epidemiology of Diabetes Complications Study

1989 • 358 citations

Risk factors for severity of diabetic polyneuropathy: intensive longitudinal assessment of the Rochester Diabetic Neuropathy Study cohort.

1999 • 328 citations

Metabolic and Vascular Factors in the Pathogenesis of Diabetic Neuropathy

1997 • 314 citations

Modern Mathematical Statistics

1989 • 307 citations

Problems with Gait and Posture in Neuropathic Patients with Insulin‐Dependent Diabetes Mellitus

1992 • 298 citations

The effect of intensive diabetes therapy on measures of autonomic nervous system function in the Diabetes Control and Complications Trial (DCCT)

1998 • 296 citations

Microangiopathy in human diabetic neuropathy: relationship between capillary abnormalities and the severity of neuropathy

1989 • 286 citations

Report and Recommendations of the San Antonio Conference on Diabetic Neuropathy

1988 • 280 citations

A 4, 2, and 1 stepping algorithm for quick and accurate estimation of cutaneous sensation threshold

1993 • 280 citations

Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy

1999 • 277 citations

Variables influencing neuropathic endpoints

1995 • 275 citations

Inhibition of Protein Kinase Cβ Prevents Impaired Endothelium-Dependent Vasodilation Caused by Hyperglycemia in Humans

2002 • 274 citations

Introduction of automated systems to evaluate touch‐pressure, vibration, and thermal cutaneous sensation in man

1978 • 204 citations

Development and validity testing of the neuropathy total symptom score-6: Questionnaire for the study of sensory symptoms of diabetic peripheral neuropathy

2005 • 178 citations

Basement membrane reduplication and pericyte degeneration precede development of diabetic polyneuropathy and are associated with its severity

1995 • 161 citations

Quantitative measurement of cutaneous perception in diabetic neuropathy

1995 • 160 citations

Vibratory and cooling detection thresholds compared with other tests in diagnosing and staging diabetic neuropathy

1988 • 156 citations

A Multicenter Study on the Prevalence of Diabetic Neuropathy in Italy

1997 • 152 citations

Modern Mathematical Statistics.

1989 • 151 citations

SENSORY ACTION POTENTIALS AND BIOPSY OF THE SURAL NERVE IN NEUROPATHY

1978 • 143 citations

Diabetes, peripheral neuropathy, and old age disability

2001 • 138 citations

Independent effects of peripheral nerve dysfunction on lower-extremity physical function in old age: the Women's Health and Aging Study.

2000 • 131 citations

Clinical Trials of Diabetic Neuropathy: Past, Present, and Future

1995 • 106 citations

A Comparison of Gait Characteristics Between Older Women with and Without Peripheral Neuropathy in Standard and Challenging Environments

2004 • 104 citations

Effects of the protein kinase Cβ inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes

2002 • 103 citations

Positive neuropathic sensory symptoms as endpoints in diabetic neuropathy trials

2001 • 103 citations

Epidemiological correlates of diabetic neuropathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study

1989 • 100 citations

Factors in development of diabetic neuropathy. Baseline analysis of neuropathy in feasibility phase of Diabetes Control and Complications Trial (DCCT). The DCCT Research Group

1988 • 95 citations

Nerve conduction measures in mild diabetic neuropathy in the Early Diabetes Intervention Trial

1996 • 92 citations

Diagnosis and Management of Diabetic Neuropathy

1999 • 81 citations

Vibratory Perception in Normal Subjects

1957 • 77 citations

Clinical utility of dorsal sural nerve conduction studies

2001 • 77 citations

Vibratory Perception in Diabetics

1957 • 73 citations

Impact of low frequency transcutaneous electrical nerve stimulation on symptomatic diabetic neuropathy using the new Salutaris device.

2004 • 68 citations

The role of protein kinase C in the development of the complications of diabetes

2000 • 67 citations

Possible role of the protein kinase C/CPI‐17 pathway in the augmented contraction of human myometrium after gestation

2003 • 67 citations

Outcome on diabetic foot complications in relation to clinical examination and quantitative sensory testing: a case-control study

1998 • 66 citations

Sural nerve myelinated fiber density differences associated with meaningful changes in clinical and electrophysiologic measurements

1996 • 61 citations

Peripheral and autonomic nerve function in 259 diabetic patients with peripheral neuropathy treated with ponalrestat (an aldose reductase inhibitor) or placebo for 18 months

1992 • 58 citations

New developments in the diagnosis of diabetic neuropathy

1999 • 58 citations

Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapy

2005 • 58 citations

Clinical trials of diabetic neuropathy: past, present, and future

1995 • 46 citations

Electronic Case-Report Forms of Symptoms and Impairments of Peripheral Neuropathy

2002 • 45 citations

Progression Rates of Diabetic Neuropathy in Placebo Patients in an 18-Month Clinical Trial

1998 • 29 citations

The usefulness of minimal F-wave latency and sural/radial amplitude ratio in diabetic polyneuropathy

2000 • 26 citations

A Placebo‐controlled Double‐blind Study of Epalrestat (ONO‐2235) in Patients with Diabetic Neuropathy

1993 • 25 citations

Design of Controlled Clinical Trials for Diabetic Polyneuropathy

1996 • 23 citations

Prospects for Kinase Activity Modulators in the Treatment of Diabetes and Diabetic Complications

2002 • 23 citations

Distal sensory nerves of the lower extremity in peripheral neuropathy: comparison of medial dorsal cutaneous and sural nerve abnormalities.

1985 • 18 citations

Diabetic neuropathy: electrophysiologic abnormalities of distal lower extremity sensory nerves.

1986 • 16 citations

Cited By (0)

Loading...