Pimagedine: a novel therapy for diabetic nephropathy

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes

2001 • 2,520 citations

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

1999 • 2,452 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

1986 • 1,154 citations

Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

1998 • 1,102 citations

The Advanced Glycation End Product, N∊-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions

1996 • 780 citations

Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy

1997 • 774 citations

Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker

2001 • 710 citations

Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial

1995 • 666 citations

Vascular Endothelial Growth Factor–Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform–Selective Inhibitor

1997 • 665 citations

The Effect of Dietary Protein Restriction on the Progression of Diabetic and Nondiabetic Renal Diseases

1996 • 656 citations

Glycation and Diabetic Complications

1994 • 634 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Hypertriglyceridemia, insulin resistance, and the metabolic syndrome

1999 • 607 citations

An agent cleaving glucose-derived protein crosslinks in vitro and in vivo

1996 • 466 citations

Nutritional and toxicological aspects of the Maillard browning reaction in foods

1989 • 464 citations

Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats.

1994 • 463 citations

Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

1996 • 460 citations

Breakers of advanced glycation end products restore large artery properties in experimental diabetes

1998 • 436 citations

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

2000 • 425 citations

Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozocin-induced diabetic rat

1991 • 395 citations

Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure

1994 • 374 citations

THORPE SR ROLE OF OXIDATIVE STRESS IN DIABETIC COMPLICATIONS: A NEW PERSPECTIVE ON AN OLD PARADIGM

1999 • 342 citations

Mechanistic Studies of Advanced Glycosylation End Product Inhibition by Aminoguanidine

1992 • 341 citations

An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness

2000 • 331 citations

Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications.

1999 • 309 citations

Amadorins: Novel Post-Amadori Inhibitors of Advanced Glycation Reactions

1999 • 271 citations

Mechanisms of diabetic vasculopathy: an overview

2001 • 264 citations

A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

2001 • 259 citations

Design and Baseline Characteristics for the Aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II)

1999 • 245 citations

Lipoxidation products as biomarkers of oxidative damage to proteins during lipid peroxidation reactions

1996 • 245 citations

Progression of Nephropathy in Spontaneous Diabetic Rats Is Prevented by OPB-9195, a Novel Inhibitor of Advanced Glycation

1997 • 229 citations

A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.

1999 • 223 citations

Biological effects of aminoguanidine: An update

1999 • 215 citations

Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195

1999 • 213 citations

Diabetic neuropathy: pathogenesis and therapy

1999 • 209 citations

Renoprotective effects of a novel inhibitor of advanced glycation

2001 • 165 citations

Renoprotective effects of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes

2002 • 161 citations

Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment

1996 • 160 citations

Captopril reduces the risk of nephropathy in IDDM patients with microalbuminuria

1996 • 159 citations

Immunohistochemical study of human advanced glycosylation end-products (AGE) in chronic renal failure.

1994 • 156 citations

Captopril reduces the risk of nephropathy in IDDM patients with microalbuminuria

1996 • 155 citations

Evidence that pioglitazone, metformin and pentoxifylline are inhibitors of glycation

2000 • 152 citations

Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-α and inducible nitric oxide synthase in diabetic rat glomeruli

1999 • 150 citations

Amides Are Novel Protein Modifications Formed by Physiological Sugars

2001 • 135 citations

Aminoguanidine Ameliorates Overexpression of Prosclerotic Growth Factors and Collagen Deposition in Experimental Diabetic Nephropathy

2001 • 133 citations

The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat

1995 • 132 citations

Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo

1995 • 131 citations

Zur Hemmung der Diaminooxydase (Histaminase)

1952 • 122 citations

Potential Therapeutic Approaches to the Treatment or Prevention of Diabetic Neuropathy: Evidence from Experimental Studies

1993 • 121 citations

Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C.

2000 • 121 citations

Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats

1992 • 110 citations

Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats

1997 • 102 citations

The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation

2000 • 100 citations

Nϵ-(carboxymethyl)lysine levels in patients with type 2 diabetes: Role of renal function

2001 • 100 citations

Prevention of glomerular basement membrane thickening by aminoguanidine in experimental diabetes mellitus

1991 • 91 citations

Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding

1999 • 77 citations

Renin-angiotensin system dependence of renal hemodynamics in mice.

1999 • 68 citations

Inhibitory effects of pyridoxal phosphate, ascorbate and aminoguanidine on nonenzymatic glycosylation

1988 • 68 citations

Beneficial effects of adopting an aggressive intravenous iron policy in a hemodialysis unit

1999 • 67 citations

DIABETIC VASCULAR COMPLICATIONS

1997 • 66 citations

Magnetic Resonance Imaging-Based Hippocampal Volumetry in Patients with Dementia of the Alzheimer Type

1999 • 65 citations

Aminoguanidine treatment reduces the increase in collagen stability of rats with experimental diabetes mellitus

1992 • 60 citations

Chronic Dosing With Aminoguanidine and Novel Advanced Glycosylation End Product-Formation Inhibitors Ameliorates Cross-Linking of Tail Tendon Collagen in STZ-Induced Diabetic Rats

1996 • 51 citations

A novel inhibitor of advanced glycation end-product formation inhibits mesenteric vascular hypertrophy in experimental diabetes

1999 • 48 citations

Nonenzymatic Glycosylation of Macromolecules: Prospects of Pharmacologic Modulation

1992 • 47 citations

Advanced nonenzymatic glycation endproducts (AGE): their relevance to aging and the pathogenesis of late diabetic complications.

1991 • 46 citations

Inhibitors of advanced glycation end product-associated protein cross-linking

2001 • 34 citations

Pharmacological Treatment Strategies in Age-Related Cataracts

1992 • 32 citations

Aminoguanidine‐provoked leukocyte adherence to rat mesenteric venules: role of constitutive nitric oxide synthase inhibition

1995 • 32 citations

Effects of aminoguanidine on serum advanced glycation endproducts, urinary albilmin excretion, mesangial expansion, and glomerular basement membrane thickening in Otsuka Long-Evans Tokushima fatty rats

1997 • 31 citations

Aminoguanidine decreases urinary albumin and high-molecular-weight proteins in diabetic rats

1991 • 30 citations

The pharmacokinetics of aminoguanidine in end-stage renal disease patients on hemodialysis

1995 • 27 citations

Active site modification of aldose reductase by nitric oxide donors

1997 • 27 citations

Aminoguanidine ameliorates changes in the IGF system in experimental diabetic nephropathy

2000 • 25 citations

Advanced glycation end products (AGEs)‐induced expression of TGF‐β1 is suppressed by a protease in the tubule cell line LLC‐PK1

2001 • 24 citations

CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme

1997 • 22 citations

N-phenacylthiazolium bromide decreases renal and increases urinary advanced glycation end products excretion without ameliorating diabetic nephropathy in C57BL/6 mice

2001 • 20 citations

Publish and Perish ?

1999 • 19 citations

Stabilization of S-adenosylmethionine decarboxylase by aminoguanidine

1993 • 16 citations

What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine?

1996 • 11 citations

Silicagel-Dünnschichtchromatographie von Nucleosiden, Nucleotiden und Oligonucleotiden

1967 • 9 citations

Does combined blockade of RAS and advanced glycation end-product formation confer superior renoprotection in a hypertensive model of diabetic nephropathy?

2002 • 1 citations