Expressional Regulation of Angiopoietin-1 and -2 and the Tie-1 and -2 Receptor Tyrosine Kinases during Cutaneous Wound Healing: A Comparative Study of Normal and Impaired Repair

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1

1999 • 1,372 citations

Constitutive Expression of phVEGF ₁₆₅ After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia

1998 • 1,109 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.

1992 • 880 citations

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

1998 • 876 citations

Increased Vascularization in Mice Overexpressing Angiopoietin-1

1998 • 818 citations

Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development

1999 • 795 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development

1996 • 684 citations

Large induction of keratinocyte growth factor expression in the dermis during wound healing.

1992 • 603 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1995 • 517 citations

Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis

1998 • 491 citations

Rescue of Diabetes-Related Impairment of Angiogenesis by Intramuscular Gene Therapy with Adeno-VEGF

1999 • 473 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

1999 • 463 citations

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

1997 • 410 citations

Diabetes-Obesity Syndromes in Mice

1982 • 357 citations

Production of Vascular Endothelial Growth Factor by Murine Macrophages

1998 • 304 citations

The Molecular Genetics of Rodent Single Gene Obesities

1997 • 293 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

Expression of the Vascular Endothelial Growth Factor C Receptor VEGFR-3 in Lymphatic Endothelium of the Skin and in Vascular Tumors

1998 • 206 citations

Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors.

1995 • 205 citations

Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.

1993 • 129 citations

Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas.

1994 • 112 citations

Molecular cloning of murine FLT and FLT4.

1993 • 90 citations

Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1.

1993 • 90 citations

Diabetes and obesity.

1996 • 75 citations

von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene

1995 • 48 citations

Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis

1996 • 48 citations

von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene [published erratum appears in Blood 1995 Sep 15;86(6):2461]

1994 • 42 citations

von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene [published erratum appears in Blood 1995 Sep 15;86(6):2461]

1994 • 32 citations