Uncoupling Raf1 from MEK1/2 Impairs Only a Subset of Cellular Responses to Raf Activation

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

The ins and outs of Raf kinases

1994 • 537 citations

Activation of the Protein Kinase ERK5/BMK1 by Receptor Tyrosine Kinases

1999 • 518 citations

New Insights into the Control of MAP Kinase Pathways

1999 • 431 citations

Random mutagenesis of gene-sized DNA molecules by use of PCR with Taq DNA polymerase

1991 • 243 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

1995 • 231 citations

Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase

1997 • 225 citations

The 90-kDa Ribosomal S6 Kinase (pp90rsk) Phosphorylates the N-terminal Regulatory Domain of IκBα and Stimulates Its Degradation in Vitro

1997 • 207 citations

Stimulation of NFκB Activity by Multiple Signaling Pathways Requires PAK1

2000 • 188 citations

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1994 • 186 citations

Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

2000 • 174 citations

Rapid Phosphorylation of Ets-2 Accompanies Mitogen-Activated Protein Kinase Activation and the Induction of Heparin-Binding Epidermal Growth Factor Gene Expression by Oncogenic Raf-1

1997 • 162 citations

Identification of Substrates and Regulators of the Mitogen-activated Protein Kinase ERK5 Using Chimeric Protein Kinases

1998 • 155 citations

Contribution of the ERK5/MEK5 Pathway to Ras/Raf Signaling and Growth Control

1999 • 134 citations

Ral GTPases Contribute to Regulation of Cyclin D1 through Activation of NF-κB

2000 • 105 citations

Raf, but Not MEK or ERK, Is Sufficient for Differentiation of Hippocampal Neuronal Cells

1996 • 89 citations

Oncogenic Raf-1 Activates p70 S6 Kinase via a Mitogen-activated Protein Kinase-independent Pathway

1996 • 88 citations

Physical Association with Ras Enhances Activation of Membrane-bound Raf (RafCAAX)

1997 • 88 citations

Induction of Heparin-binding EGF-like Growth Factor Expression during Myogenesis

1995 • 62 citations

Activation of NF-κB by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade

1998 • 48 citations

Ras- and Raf-induced Down-modulation of Non-muscle Tropomyosin Are MEK-independent

1998 • 37 citations

The Ankyrin Repeat-containing Adaptor Protein Tvl-1 Is a Novel Substrate and Regulator of Raf-1

1999 • 35 citations

The Role of Raf Kinases in Development and Growth of Tumors

1997 • 34 citations

A Raf‐induced, MEK‐independent signaling pathway regulates atrial natriuretic factor gene expression in cardiac muscle cells

2000 • 15 citations