Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma.

Tumor Suppressor Genes

1991 • 1,784 citations

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

2000 • 1,073 citations

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

1999 • 801 citations

Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

2001 • 770 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.

2000 • 400 citations

Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours

2001 • 379 citations

Ras Uses the Novel Tumor Suppressor RASSF1 as an Effector to Mediate Apoptosis

2000 • 295 citations

High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma.

2001 • 290 citations

Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.

2001 • 286 citations

Identification of Nore1 as a Potential Ras Effector

1998 • 209 citations

A novel family ofras-binding domains

1996 • 207 citations

p53 in Prostate Cancer: Frequent Expressed Transition Mutations

1994 • 180 citations

Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene

1998 • 147 citations

Gastric adenocarcinoma: pathomorphology and molecular pathology

2001 • 145 citations

Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines.

1996 • 113 citations

Loss of FHIT expression in gastric carcinoma.

1998 • 109 citations

Allelotype of gastric adenocarcinoma.

1999 • 93 citations

Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma.

2000 • 79 citations

Mutational abrogation of the gene in gastrointestinal polyps in patients with Cowden disease

1998 • 49 citations

Frequent alteration of CDKN2 (p16(INK4A)/MTS1) expression in human primary prostate carcinomas.

1997 • 44 citations

Fractional allelic loss in gastric carcinoma correlates with growth patterns

1998 • 38 citations

Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.

2000 • 9 citations