Lipid raft domains and protein networks in T-cell receptor signal transduction

Functional rafts in cell membranes

1997 • 9,471 citations

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

2002 • 2,231 citations

Lipid Rafts

2003 • 1,485 citations

LAT

1998 • 1,251 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

2002 • 1,130 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Phospholipids undergo hop diffusion in compartmentalized cell membrane

2002 • 878 citations

Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes

2004 • 865 citations

LAT Palmitoylation

1998 • 837 citations

Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor

1999 • 800 citations

On the Origin of Sphingolipid/Cholesterol-Rich Detergent-Insoluble Cell Membranes: Physiological Concentrations of Cholesterol and Sphingolipid Induce Formation of a Detergent-Insoluble, Liquid-Ordered Lipid Phase in Model Membranes

1997 • 661 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

2002 • 597 citations

T-cell-antigen recognition and the immunological synapse

2003 • 587 citations

Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?

1997 • 512 citations

Visualizing lipid structure and raft domains in living cells with two-photon microscopy

2003 • 507 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Location is Everything: Lipid Rafts and Immune Cell Signaling

2003 • 477 citations

High-Resolution FRET Microscopy of Cholera Toxin B-Subunit and GPI-anchored Proteins in Cell Plasma Membranes

2000 • 427 citations

TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts

2002 • 330 citations

Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers

2001 • 329 citations

Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells : accumulation of actin regulated by local tyrosine phosphorylation

1999 • 316 citations

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

2002 • 278 citations

Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

2002 • 265 citations

Signaling Life and Death in the Thymus: Timing Is Everything

2003 • 255 citations

Condensed complexes, rafts, and the chemical activity of cholesterol in membranes

2000 • 233 citations

CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56lck Complexes

2001 • 213 citations

Differential extractability of influenza virus hemagglutinin during intracellular transport in polarized epithelial cells and nonpolar fibroblasts.

1989 • 204 citations

Non–T Cell Activation Linker (NTAL)

2002 • 203 citations

Lipid raft proteins have a random distribution during localized activation of the T-cell receptor

2004 • 200 citations

The tyrosine kinase connection: how GPI-anchored proteins activate T cells

1993 • 198 citations

Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT

2001 • 194 citations

Dynamics of raft molecules in the cell and artificial membranes: approaches by pulse EPR spin labeling and single molecule optical microscopy

2003 • 192 citations

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

2000 • 178 citations

Identification of the Minimal Tyrosine Residues Required for Linker for Activation of T Cell Function

2001 • 166 citations

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

2002 • 165 citations

Selective Accumulation of Raft-Associated Membrane Protein Lat in T Cell Receptor Signaling Assemblies

2000 • 154 citations

LAB: A new membrane-associated adaptor molecule in B cell activation

2003 • 154 citations

LAT regulates γδ T cell homeostasis and differentiation

2003 • 113 citations

The role of membrane-associated adaptors in T cell receptor signalling

2000 • 111 citations

Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts

2003 • 107 citations

Minimal Requirement of Tyrosine Residues of Linker for Activation of T Cells in TCR Signaling and Thymocyte Development

2003 • 107 citations

Formation and function of the immunological synapse

2002 • 106 citations

LIME

2003 • 104 citations

Pulse EPR Detection of Lipid Exchange between Protein-Rich Raft and Bulk Domains in the Membrane: Methodology Development and Its Application to Studies of Influenza Viral Membrane

2001 • 102 citations

LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation

2003 • 93 citations

Cell calcium signaling via GM1 cell surface gangliosides in the human Jurkat T cell line.

1994 • 79 citations

Lymphocyte lipid rafts: structure and function

2003 • 78 citations

Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activation

2003 • 77 citations

T Cell Receptor Can Be Recruited to a Subset of Plasma Membrane Rafts, Independently of Cell Signaling and Attendantly to Raft Clustering

2003 • 69 citations

Transmembrane adapters: attractants for cytoplasmic effectors

2003 • 54 citations

Synergistic Assembly of Linker for Activation of T Cells Signaling Protein Complexes in T Cell Plasma Membrane Domains

2003 • 51 citations

Binding of NAP-22, a Calmodulin-Binding Neuronal Protein, to Raft-like Domains in Model Membranes

2003 • 40 citations