Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

2006 • 1,564 citations

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

2000 • 1,304 citations

Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

2006 • 1,292 citations

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

2004 • 1,109 citations

Rapid Detection of West Nile Virus from Human Clinical Specimens, Field-Collected Mosquitoes, and Avian Samples by a TaqMan Reverse Transcriptase-PCR Assay

2000 • 1,086 citations

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

2007 • 1,082 citations

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

2004 • 946 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

Innate Recognition of Viruses

2007 • 671 citations

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

2008 • 621 citations

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia

2006 • 487 citations

Toll-like Receptors and Type I Interferons

2007 • 475 citations

B Cells and Antibody Play Critical Roles in the Immediate Defense of Disseminated Infection by West Nile Encephalitis Virus

2003 • 473 citations

Antiviral Signaling Through Pattern Recognition Receptors

2006 • 441 citations

Alpha/Beta Interferon Protects against Lethal West Nile Virus Infection by Restricting Cellular Tropism and Enhancing Neuronal Survival

2005 • 411 citations

Neuronal CXCL10 Directs CD8⁺T-Cell Recruitment and Control of West Nile Virus Encephalitis

2005 • 405 citations

Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection

2005 • 385 citations

Does Toll-like receptor 3 play a biological role in virus infections?

2004 • 354 citations

Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion

2006 • 337 citations

Virus Infection Switches TLR-3-Positive Human Neurons To Become Strong Producers of Beta Interferon

2005 • 336 citations

Isolation of West Nile Virus from Mosquitoes, Crows, and a Cooper's Hawk in Connecticut

1999 • 329 citations

Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1

2007 • 313 citations

Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3

2008 • 308 citations

Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope Protein

2006 • 298 citations

A Critical Role for Induced IgM in the Protection against West Nile Virus Infection

2003 • 296 citations

Neurons produce type I interferon during viral encephalitis

2006 • 250 citations

Preferential expression and function of Toll-like receptor 3 in human astrocytes

2004 • 248 citations

Toll‐like receptors, RIG‐I‐like RNA helicases and the antiviral innate immune response

2007 • 245 citations

PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons

2006 • 239 citations

Maturation of Japanese encephalitis virus glycoproteins produced by infected mammalian and mosquito cells

1989 • 231 citations

CD8⁺T Cells Require Perforin To Clear West Nile Virus from Infected Neurons

2005 • 210 citations

Cell-Specific IRF-3 Responses Protect against West Nile Virus Infection by Interferon-Dependent and -Independent Mechanisms

2007 • 192 citations

West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling

2006 • 188 citations

Gamma Interferon Plays a Crucial Early Antiviral Role in Protection against West Nile Virus Infection

2006 • 187 citations

Microglia Recognize Double-Stranded RNA via TLR3

2006 • 184 citations

West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal Transduction

2008 • 169 citations

Principles of intracellular viral recognition

2006 • 164 citations

Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury

2006 • 163 citations

TLR3 Deletion Limits Mortality and Disease Severity due to Phlebovirus Infection

2006 • 126 citations

Partial Genetic Characterization of West Nile Virus Strains, New York State, 2000

2001 • 112 citations

Antigen‐specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis

2007 • 110 citations

A missense mutation of the Toll-like receptor 3 gene in a patient with influenza-associated encephalopathy

2006 • 100 citations

Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases

2006 • 99 citations

Differential Induction of Type I Interferon Responses in Myeloid Dendritic Cells by Mosquito and Mammalian-Cell-Derived Alphaviruses

2006 • 97 citations

Partial Genetic Characterization of West Nile Virus Strains, New York State, 2000

2001 • 96 citations

Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood–brain barrier dysfunction in stroke

2007 • 96 citations

Differential Activation of Human Monocyte-Derived and Plasmacytoid Dendritic Cells by West Nile Virus Generated in Different Host Cells

2007 • 92 citations

Increased blood–brain barrier permeability is not a primary determinant for lethality of West Nile virus infection in rodents

2008 • 89 citations

TLR3 Increases Disease Morbidity and Mortality from Vaccinia Infection

2008 • 84 citations

CD40-CD40 Ligand Interactions Promote Trafficking of CD8 ⁺ T Cells into the Brain and Protection against West Nile Virus Encephalitis

2007 • 78 citations

Polyriboinosinic polyribocytidylic acid [poly(I:C)]/TLR3 signaling allows class I processing of exogenous protein and induction of HIV-specific CD8+ cytotoxic T lymphocytes

2003 • 73 citations

West Nile Virus Envelope Protein Inhibits dsRNA-Induced Innate Immune Responses

2007 • 71 citations

West Nile virus replication interferes with both poly(I:C)-induced interferon gene transcription and response to interferon treatment

2005 • 70 citations

TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help

2007 • 64 citations

Characterization of Defective Viral RNA Produced during Persistent Infection of Vero Cells with Murray Valley Encephalitis Virus

1998 • 56 citations

Translational Mini-Review Series on Toll-like Receptors:
Recent advances in understanding the role of Toll-like receptors in anti-viral immunity

2007 • 49 citations

Double‐stranded RNA mediates interferon regulatory factor 3 activation and interleukin‐6 production by engaging Toll‐like receptor 3 in human brain astrocytes

2008 • 44 citations

In vitro homotypic and heterotypic interference by defective interfering particles of West Nile virus

1991 • 25 citations

Signalling pathways mediating type I interferon gene expression

2007 • 22 citations