TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway

Phosphoinositides in cell regulation and membrane dynamics

2006 • 2,604 citations

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

2007 • 2,524 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Rab Conversion as a Mechanism of Progression from Early to Late Endosomes

2005 • 1,573 citations

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

2001 • 1,231 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

2004 • 1,186 citations

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

2008 • 1,153 citations

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

2003 • 1,137 citations

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

2003 • 1,023 citations

Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus

1990 • 979 citations

HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2

2006 • 802 citations

Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

2006 • 797 citations

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

2008 • 589 citations

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

2008 • 458 citations

Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

2006 • 456 citations

Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction

2002 • 452 citations

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

2003 • 450 citations

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

2007 • 418 citations

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

2008 • 411 citations

gp25L/emp24/p24 Protein Family Members of the cis-Golgi Network Bind Both COP I and II Coatomer

1998 • 335 citations

Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-κB Activation by Alternative Splicing of MyD88

2002 • 275 citations

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

2006 • 263 citations

Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4

2007 • 203 citations

IRAK-2 Participates in Multiple Toll-like Receptor Signaling Pathways to NFκB via Activation of TRAF6 Ubiquitination

2007 • 203 citations

Development of TLR inhibitors for the treatment of autoimmune diseases

2008 • 194 citations

A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins

2007 • 189 citations

The GOLD domain, a novel protein module involved in Golgi function and secretion

2002 • 170 citations

Trif-related adapter molecule is phosphorylated by PKCε during Toll-like receptor 4 signaling

2006 • 137 citations

The Murine Irak2 Gene Encodes Four Alternatively Spliced Isoforms, Two of Which Are Inhibitory

2004 • 105 citations