An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

Gout-associated uric acid crystals activate the NALP3 inflammasome

2006 • 4,851 citations

Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study

2004 • 4,332 citations

Toll-like receptors in innate immunity

2004 • 3,233 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

2006 • 2,874 citations

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

2008 • 2,815 citations

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

2008 • 2,505 citations

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

2009 • 2,348 citations

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

2008 • 2,199 citations

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

2009 • 1,699 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

2007 • 1,609 citations

Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

2003 • 1,593 citations

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

2008 • 1,465 citations

A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

1995 • 1,239 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Intracellular pattern recognition receptors in the host response

2006 • 1,170 citations

Dectin-1 Mediates the Biological Effects of β-Glucans

2003 • 1,167 citations

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

1997 • 1,137 citations

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

2006 • 1,099 citations

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

2006 • 1,097 citations

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

2009 • 1,040 citations

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

2009 • 1,021 citations

Dectin-1 Is A Major β-Glucan Receptor On Macrophages

2002 • 964 citations

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

2008 • 920 citations

Altered Cytokine Production in Mice Lacking P2X7Receptors

2001 • 918 citations

Inflammatory Caspases

2004 • 917 citations

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

2009 • 869 citations

Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

2005 • 844 citations

Function of Nod‐like receptors in microbial recognition and host defense

2008 • 815 citations

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

2009 • 799 citations

Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

1998 • 761 citations

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

2009 • 702 citations

Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

2006 • 681 citations

NLRs join TLRs as innate sensors of pathogens

2005 • 663 citations

Inflammasome recognition of influenza virus is essential for adaptive immune responses

2009 • 662 citations

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments

2005 • 638 citations

EngineeredControl of Cell Morphology In Vivo Reveals Distinct Roles for Yeast andFilamentous Forms of Candida albicans duringInfection

2003 • 617 citations

The IL-1 family and inflammatory diseases.

2004 • 597 citations

Predominant pathogens in hospital infections

1992 • 593 citations

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

2004 • 568 citations

The Contribution of the Toll-Like/IL-1 Receptor Superfamily to Innate and Adaptive Immunity to Fungal Pathogens In Vivo

2004 • 500 citations

Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).

1999 • 462 citations

Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf

2006 • 445 citations

Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

2004 • 443 citations

C-type lectins and phagocytosis

2009 • 289 citations

Pseudomonas aeruginosa activates caspase 1 through Ipaf

2008 • 287 citations

Denture‐related stomatitis: identification of aetiological and predisposing factors – a large cohort

2007 • 221 citations

Relationship between cell surface composition, adherence, and virulence of Candida albicans

1984 • 219 citations

Involvement of Caspase-1 and Caspase-3 in the Production and Processing of Mature Human Interleukin 18 in Monocytic THP.1 Cells

1997 • 198 citations

The inflammasome in pathogen recognition and inflammation

2007 • 165 citations

Cytokine and Chemokine Production by Human Oral and Vaginal Epithelial Cells in Response toCandida albicans

2002 • 165 citations

Endogenous Interleukin (IL)–1α and IL‐1β Are Crucial for Host Defense against Disseminated Candidiasis

2006 • 157 citations

Nucleotide-Binding Oligomerization Domain-Like Receptors: Intracellular Pattern Recognition Molecules for Pathogen Detection and Host Defense

2006 • 144 citations

RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity

2007 • 138 citations

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors

2008 • 134 citations

Interleukin-1β

2005 • 129 citations

Toll-like Receptor-dependent and -independent Viperin Gene Expression and Counter-regulation by PRDI-binding Factor-1/BLIMP1

2006 • 120 citations

The prevalence of Candida albicans populations in the mouths of complete denture wearers.

1998 • 106 citations

Occurrence rate of oral Candida albicans in denture wearer patients.

2006 • 97 citations

Candida albicans triggers interleukin-8 secretion by oral epithelial cells

2003 • 94 citations

NLRC4/IPAF: a CARD carrying member of the NLR family

2008 • 83 citations

Interleukin 18 Restores Defective Th1 Immunity toCandida albicansin Caspase 1-Deficient Mice

2000 • 80 citations

Bypassing Pathogen‐Induced Inflammasome Activation for the Regulation of Interleukin‐1β Production by the Fungal PathogenCandida albicans

2009 • 73 citations

Candida albicans and Streptococcus salivarius modulate IL-6, IL-8, and TNF-alpha expression and secretion by engineered human oral mucosa cells

2004 • 69 citations

The Role of Endogenous Interleukin (IL)–18, IL‐12, IL‐1β, and Tumor Necrosis Factor–α in the Production of Interferon‐γ Induced byCandida albicansin Human Whole‐Blood Cultures

2002 • 64 citations

Use of a Genetically Engineered Strain To Evaluate the Pathogenic Potential of Yeast Cell and Filamentous Forms duringCandida albicansSystemic Infection in Immunodeficient Mice

2007 • 49 citations

Hyphal Invasion of Candida albicans Inhibits the Expression of Human β-Defensins in Experimental Oral Candidiasis

2006 • 48 citations

Role of Interleukin-18 in Host Defense against DisseminatedCandida albicansInfection

2002 • 46 citations

Morphological aspects of gastrointestinal tract invasion byCandida albicansin the infant mouse

1988 • 45 citations

Bioactive interleukin-1α is cytolytically released fromCandida albicans-infected oral epithelial cells

2004 • 37 citations

Recombinant Interleukin‐18 Protects against DisseminatedCandida albicansInfection in Mice

2004 • 32 citations