Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

1982 • 1,765 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

[6] Preparation of microsomal membranes for cotranslational protein translocation

1983 • 679 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis

1986 • 560 citations

[4] Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA

1983 • 547 citations

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.

1989 • 349 citations

Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.

1986 • 346 citations

Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.

1987 • 297 citations

Expression in Non-Hodgkin's Lymphoma of thebcl-2 Protein Associated with the t(14;18) Chromosomal Translocation

1988 • 292 citations

Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants

1985 • 277 citations

Oncogenic potential of bcl-2 demonstrated by gene transfer

1988 • 180 citations

Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein.

1984 • 173 citations

Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5.

1983 • 155 citations

Virus-specific proteins in the plasma membrane of cells lytically infected or transformed by pol-oma virus.

1977 • 139 citations

Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells.

1989 • 131 citations

A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum.

1982 • 118 citations

The membrane-embedded segment of cytochrome b5 as studied by cross-linking with photoactivatable phospholipids. II. The nontransferable form.

1983 • 75 citations

[7] Methods for the study of protein translocation across the RER membrane using the reticulocyte lysate translation system and canine pancreatic microsomal membranes

1983 • 50 citations

Membrane integration and intracellular transport of the coronavirus glycoprotein E1, a class III membrane glycoprotein.

1988 • 45 citations

Subcellular localization of the v-erb-B protein, the product of a transforming gene of avian erythroblastosis virus

1984 • 42 citations

Construction and expression of a recombinant DNA gene encoding a polyomavirus middle-size tumor antigen with the carboxyl terminus of the vesicular stomatitis virus glycoprotein G.

1984 • 33 citations

In vitro synthesized bacterial outer membrane protein is integrated into bacterial inner membranes but translocated across microsomal membranes

1986 • 22 citations