Co-evolutionary Analysis Reveals Insights into Protein–Protein Interactions

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Numerical recipes in C

1994 • 15,831 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

2002 • 3,624 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Human Chemokines: An Update

1997 • 2,235 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

1999 • 1,661 citations

Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

1999 • 1,556 citations

Regulation of myostatin activity and muscle growth

2001 • 1,536 citations

Controlling TGF-β signaling

2000 • 1,522 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Analysis of Proteins and Proteomes by Mass Spectrometry

2001 • 1,178 citations

SNARE-mediated membrane fusion

2001 • 1,121 citations

Protein interaction maps for complete genomes based on gene fusion events

1999 • 1,090 citations

Conservation of gene order: a fingerprint of proteins that physically interact

1998 • 1,054 citations

A combined algorithm for genome-wide prediction of protein function

1999 • 921 citations

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1999 • 788 citations

Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex

2000 • 783 citations

Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

1993 • 716 citations

A genomic perspective on membrane compartment organization

2001 • 693 citations

Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family

2001 • 662 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

How receptors talk to trimeric G proteins

1997 • 562 citations

Cloning and characterization of a human type II receptor for bone morphogenetic proteins.

1995 • 551 citations

Similarity of phylogenetic trees as indicator of protein–protein interaction

2001 • 511 citations

Role of chemokines in the biology of natural killer cells

2002 • 497 citations

Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11

1999 • 453 citations

Molecular Basis of Receptor/G-Protein-Coupling Selectivity

1998 • 444 citations

Co-evolution of proteins with their interaction partners 1 1Edited by B. Honig

2000 • 433 citations

The role of vascular endothelial growth factor in pathological angiogenesis

1995 • 419 citations

TGF-β receptor signaling

1997 • 417 citations

Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors

1993 • 417 citations

Chemokine/Chemokine Receptor Nomenclature

2002 • 348 citations

Chemokine receptors

2001 • 333 citations

Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion

1999 • 327 citations

Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor

1989 • 325 citations

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

1990 • 319 citations

Syntaxin 6 functions in trans-Golgi network vesicle trafficking.

1997 • 286 citations

Bone Morphogenetic Protein Receptor Complexes on the Surface of Live Cells: A New Oligomerization Mode for Serine/Threonine Kinase Receptors

2000 • 285 citations

Signaling via Vascular Endothelial Growth Factor Receptors

1999 • 281 citations

The Cystine-Knot Growth-Factor Superfamily

1995 • 281 citations

BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

2000 • 261 citations

Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry

1997 • 193 citations

The Cytokinesis Gene KEULE Encodes a Sec1 Protein That Binds the Syntaxin Knolle

2001 • 190 citations

The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein

1999 • 186 citations

Structural and mechanistic basis of immunity toward endonuclease colicins.

1999 • 165 citations

SNAREs and membrane fusion in the Golgi apparatus

1998 • 152 citations

Specificity in protein-protein interactions: the structural basis for dual recognition in endonuclease colicin-immunity protein complexes

2000 • 147 citations

Vam3p structure reveals conserved and divergent properties of syntaxins.

2001 • 147 citations

Protein-Protein Interactions in Colicin E9 DNase-Immunity Protein Complexes. 1. Diffusion-Controlled Association and Femtomolar Binding for the Cognate Complex

1995 • 142 citations

Protein Interaction Methods-Toward an Endgame

1999 • 134 citations

The syntaxins.

2001 • 131 citations

Sec1/Munc18 Proteins

2000 • 108 citations

Instruments of microbial warfare: Bacteriocin synthesis, toxicity and immunity

1998 • 105 citations

Assignment of the functional loci in colicin E2 and E3 molecules by the characterization of their proteolytic fragments

1980 • 104 citations

Immunity proteins: enzyme inhibitors that avoid the active site

2001 • 102 citations

Highly Purified Colicin E3 Contains Immunity Protein

1974 • 92 citations

Xenopus GDF6, a new antagonist of noggin and a partner of BMPs

1999 • 91 citations

Protein-Protein Interactions in Colicin E9 DNase-Immunity Protein Complexes. 2. Cognate and Noncognate Interactions That Span the Millilmolar to Femptomolar Affinity Range

1995 • 88 citations

Localization and control of expression of Nt‐Syr1, a tobacco snare protein

2000 • 87 citations

Mammalian Sly1 Regulates Syntaxin 5 Function in Endoplasmic Reticulum to Golgi Transport

1996 • 84 citations

Molecular Characterization of Mammalian Homologues of Class C Vps Proteins That Interact with Syntaxin-7

2001 • 82 citations

Munc18-2, a Functional Partner of Syntaxin 3, Controls Apical Membrane Trafficking in Epithelial Cells

2000 • 80 citations

Syntaxin 17 Is Abundant in Steroidogenic Cells and Implicated in Smooth Endoplasmic Reticulum Membrane Dynamics

2000 • 80 citations

E3 Immunity Substance

1974 • 74 citations

The BMP Family Member Gdf7 Is Required for Seminal Vesicle Growth, Branching Morphogenesis, and Cytodifferentiation

2001 • 65 citations

In vivo and in vitro characterization of overproduced colicin E9 immunity protein

1992 • 63 citations

Chemokine/Chemokine Receptor Nomenclature

2001 • 36 citations

Novel isoform of syntaxin 1 is expressed in mammalian cells

1997 • 31 citations

Protein–Protein Interactions of the Yeast Golgi t-SNARE Sed5 Protein Distinct from Its Neural Plasma Membrane Cognate Syntaxin 1

1998 • 30 citations

Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7

2002 • 13 citations

Sec1 gets a grip on syntaxin.

2000 • 10 citations

Preliminary X-ray crystallographic analysis of the complex between the DNAase domain of colicin E9 and its cognate immunity protein

1999 • 6 citations

SECuring the perimeter

2001 • 4 citations

Cited By (0)

Loading...