Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Genetic immunization is a simple method for eliciting an immune response

1992 • 1,505 citations

Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes

1981 • 1,265 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6

1997 • 486 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells

1991 • 297 citations

Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

1999 • 259 citations

Oral Salmonella: malaria circumsporozoite recombinants induce specific CD8+ cytotoxic T cells.

1990 • 207 citations

Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes.

1996 • 201 citations

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.

1996 • 189 citations

DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection

1995 • 185 citations

A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge

1993 • 176 citations

Activated and Memory CD8+ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers

2000 • 174 citations

Identification of Db- and Kb-Restricted Subdominant Cytotoxic T-Cell Responses in Lymphocytic Choriomeningitis Virus-Infected Mice

1998 • 164 citations

DNA Immunization with Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral Protection Are Rectified by Ubiquitination

1998 • 148 citations

Cytotoxic T Cell Responses to DNA Vaccination: Dependence on Antigen Presentation via Class II MHC

1998 • 135 citations

Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope

1991 • 135 citations

Vaccination and protection from a lethal viral infection: Identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope

1990 • 132 citations

Long-Term CD4 Th1 and Th2 Memory following Acute Lymphocytic Choriomeningitis Virus Infection

1998 • 126 citations

Recombinant polyepitope vaccines for the delivery of multiple CD8 cytotoxic T cell epitopes.

1996 • 123 citations

Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.

1992 • 116 citations

MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies.

1997 • 110 citations

Ribosomal scanning past the primary initiation codon as a mechanism for expression of CTL epitopes encoded in alternative reading frames.

1996 • 100 citations

Detection of a high frequency of virus-specific CD4+ T cells during acute infection with lymphocytic choriomeningitis virus.

1998 • 95 citations

A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and Th epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen

1997 • 90 citations

DNA immunization

1996 • 89 citations

Cutting Edge: Detection of a High Frequency of Virus-Specific CD4+ T Cells During Acute Infection with Lymphocytic Choriomeningitis Virus

1998 • 86 citations

CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.

1992 • 79 citations

Comparison of Various Expression Plasmids for the Induction of Immune Response by DNA Immunization

1997 • 65 citations

Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes.

1989 • 62 citations

Induction of CD8+ T Cell Responses to Dominant and Subdominant Epitopes and Protective Immunity to Sendai Virus Infection by DNA Vaccination

1998 • 60 citations

Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.

1991 • 58 citations

Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice

1997 • 58 citations

Initiation Codon Scanthrough versus Termination Codon Readthrough Demonstrates Strong Potential for Major Histocompatibility Complex Class I–restricted Cryptic Epitope Expression

1997 • 51 citations

Development of BCG As a Recombinant Vaccine Vehicle

1990 • 45 citations

Qualitative and Quantitative Requirements for CD4+ T Cell-Mediated Antiviral Protection

1999 • 44 citations

Differential effects of flanking residues on presentation of epitopes from chimeric peptides

1994 • 40 citations

Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus

1994 • 39 citations

Protection by minigenes: a novel approach of DNA vaccines

1998 • 33 citations

Role of a Subdominant H-2Kd-Restricted SV40 Tumor Antigen Cytotoxic T Lymphocyte Epitope in Tumor Rejection

1998 • 29 citations

Animal Virus Pathogenesis: A Practical Approach

1990 • 20 citations

Multivalent minigene vaccines against infectious disease.

1999 • 17 citations