Role of ion channels in lymphocytes

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Handbook of fluorescent probes and research chemicals

1996 • 2,829 citations

Calcium Channels, Stores, and Oscillations

1990 • 1,208 citations

Ionic channels of excitable membranes

1985 • 1,185 citations

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

1989 • 1,039 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

1984 • 734 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

Flow Cytometry and Sorting

1991 • 669 citations

Regulation of B-Cell Growth and Differentiation by Soluble Factors

1983 • 432 citations

A voltage‐gated potassium channel in human T lymphocytes.

1985 • 403 citations

Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.

1989 • 402 citations

Voltage-gated potassium channels are required for human T lymphocyte activation.

1984 • 337 citations

Lymphocyte membrane potential assessed with fluorescent probes

1980 • 336 citations

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

1984 • 308 citations

A cerebellar Purkinje cell marker P400 protein is an inositol 1,4,5-trisphosphate (InsP3) receptor protein. Purification and characterization of InsP3 receptor complex.

1990 • 280 citations

Molecular Mechanisms of Transmembrane Signaling in B Lymphocytes

1987 • 279 citations

Calcium and T lymphocyte activation

1989 • 246 citations

Currents carried by monovalent cations through calcium channels in mouse neoplastic B lymphocytes.

1985 • 239 citations

Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets.

1987 • 231 citations

Ion transport, membrane potential, and cytoplasmic pH in lymphocytes: changes during activation

1989 • 187 citations

Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes.

1989 • 182 citations

Characterization of the cytolytic reaction mechanism of the human natural killer (NK) lymphocyte: resolution into binding, programming, and killer cell-independent steps.

1982 • 177 citations

Expression and chromosomal localization of a lymphocyte K+ channel gene.

1990 • 170 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Lymphocyte membrane potential and Ca²⁺‐sensitive potassium channels described by oxonol dye fluorescence measurements

1985 • 169 citations

Subset-Specific Expression of Potassium Channels in Developing Murine T Lymphocytes

1988 • 167 citations

TEA prevents inactivation while blocking open K+ channels in human T lymphocytes

1989 • 165 citations

A cAMP-Regulated Chloride Channel in Lymphocytes That Is Affected in Cystic Fibrosis

1989 • 163 citations

Regulation of Human B-Cell Activation and Adhesion

1991 • 161 citations

Charybdotoxin blocks voltage-gated K+ channels in human and murine T lymphocytes.

1989 • 155 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Voltage‐gated potassium conductance in human T lymphocytes stimulated with phorbol ester.

1986 • 151 citations

A Family of Three Mouse Potassium Channel Genes with Intronless Coding Regions

1990 • 150 citations

Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum

1989 • 145 citations

Role of potassium and chloride channels in volume regulation by T lymphocytes.

1988 • 142 citations

Transmembrane Signals and Intracellular “Second Messengers” in the Regulation of Quiescent B‐Lymphocyte Activation

1987 • 137 citations

Molecular Aspects of B-Lymphocyte Activation

1987 • 136 citations

Cytotoxic T‐Lymphocytes How Do They Function?

1983 • 124 citations

Is an early calcium flux necessary to stimulate lymphocytes?

1977 • 122 citations

Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes.

1986 • 121 citations

Mitogen induction of ion channels in murine T lymphocytes.

1987 • 118 citations

Ion Channels and Signal Transduction in Lymphocytes

1990 • 116 citations

Ion channel blockers inhibit B cell activation at a precise stage of the G1 phase of the cell cycle. Possible involvement of K+ channels.

1990 • 110 citations

Increased voltage-gated potassium conductance during interleukin 2-stimulated proliferation of a mouse helper T lymphocyte clone.

1986 • 104 citations

Potassium current in clonal cytotoxic T lymphocytes from the mouse.

1984 • 101 citations

Potassium channels mediate killing by human natural killer cells.

1986 • 101 citations

The multifunctional Ca2+/calmodulin-dependent protein kinase.

1988 • 99 citations

Cell Cycle Dependence of Chloride Permeability in Normal and Cystic Fibrosis Lymphocytes

1990 • 94 citations

Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals.

1989 • 90 citations

Cyclic AMP-Modulated Potassium Channels in Murine B Cells and Their Precursors

1987 • 89 citations

Ca2(+)‐activated K+ channels in human B lymphocytes and rat thymocytes.

1989 • 84 citations

Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium.

1987 • 82 citations

The plasticity of ion channels: parallels between the nervous and immune systems

1988 • 80 citations

Volume response of quiescent and interleukin 2-stimulated T-lymphocytes to hypotonicity

1988 • 75 citations

Anion channels with multiple conductance levels in a mouse B lymphocyte cell line.

1989 • 68 citations

Regulation of CI− channels by multifunctional CaM kinase

1991 • 68 citations

Activation of Ca2+-dependent K+ channels in human B lymphocytes by anti-immunoglobulin.

1988 • 68 citations

A large, multiple-conductance chloride channel in normal human T lymphocytes

1990 • 68 citations

Early plasma-membrane-potential changes during stimulation of lymphocytes by concanavalin A.

1983 • 67 citations

Voltage-gated Ca2+ channel in mouse myeloma cells.

1983 • 64 citations

Altered K ⁺ Channel Expression in Abnormal T Lymphocytes from Mice with the lpr Gene Mutation

1986 • 62 citations

B cell activation. VII. Independent and synergistic effects of mobilized calcium and diacylglycerol on membrane potential and I-A expression.

1986 • 61 citations

ATP-induced activation of human B lymphocytes via P2-purinoceptors.

1991 • 60 citations

Synergistic action of A23187 and phorbol ester on human B cell activation.

1985 • 60 citations

Patch Clamp Studies of Lymphocyte Activation

1990 • 60 citations

Potassium channels in human NK cells are involved in discrete stages of the killing process.

1986 • 55 citations

Heterogeneity of lymphocyte calcium metabolism is caused by T cell-specific calcium-sensitive potassium channel and sensitivity of the calcium ATPase pump to membrane potential.

1988 • 51 citations

Cell Volume Regulation in Lymphocytes

1988 • 49 citations

Triggering of T-lymphocytes via Either T3-Ti or T11 Surface Structures Opens a Voltage-insensitive Plasma Membrane Calcium-permeable Channel: Requirement for Interleukin-2 Gene Function

1989 • 46 citations

Changes in the expression of potassium channels during mouse T cell development.

1986 • 44 citations

Antibody to a novel 95-kDa surface glycoprotein on human B cells induces calcium mobilization and B cell activation.

1988 • 42 citations

Cross-linking membrane IgM induces production of inositol trisphosphate and inositol tetrakisphosphate in WEHI-231 B lymphoma cells.

1987 • 41 citations

Cloned T-cell proliferation and synthesis of specific proteins are inhibited by quinine.

1986 • 41 citations

The inhibitory effects of K+ channel-blocking agents on T lymphocyte proliferation and lymphokine production are 'nonspecific'

1988 • 40 citations

Spatial and temporal characteristics of the increase in intracellular Ca2+ induced in cytotoxic T lymphocytes by cellular antigen.

1988 • 38 citations

Ion channels and b cell mitogenesis

1990 • 36 citations

The relationship between mitogen-induced membrane potential changes and intracellular free calcium in human T-lymphocytes

1986 • 35 citations

Cytolytic T lymphocyte effector function requires plasma membrane chloride flux.

1986 • 34 citations

Affinity requirements for induction of sequential phases of human B cell activation by membrane IgM-cross-linking ligands.

1991 • 32 citations

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid inhibits CD3-T cell antigen receptor-stimulated Ca2+ influx in human T lymphocytes.

1988 • 30 citations

Transmembrane ion conductance in human B lymphocyte activation.

1990 • 28 citations

The inhibitory effects of K+ channel-blocking agents on T lymphocyte proliferation and lymphokine production are "nonspecific".

1987 • 27 citations

Activation of dense human tonsilar B cells. Induction of c-myc gene expression via two distinct signal transduction pathways.

1991 • 26 citations

Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases?

1988 • 24 citations

Ion channels activated by specific Ti or T3 antibodies in plasma membranes of human T cells.

1987 • 23 citations

Modulation of voltage-dependent potassium channels in B lymphocytes

1988 • 23 citations

Accelerated 86Rb+ (K+) release from the cytotoxic T lymphocyte is a physiologic event associated with delivery of the lethal hit.

1983 • 19 citations

Patch-clamp profile of ion channels in resting murine B lymphocytes

1990 • 19 citations

Voltage-Sensitive Ion Channels in Human B Lymphocytes

1989 • 17 citations

Transmembrane chloride flux is required for target cell lysis but not for Golgi reorientation in cloned cytolytic effector cells. Golgi reorientation, N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase release, and delivery of the lethal hit are separable events in target cell lysis.

1988 • 17 citations

CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels.

1990 • 17 citations

Preface

1991 • 14 citations

Regulation of interleukin-2 production and phosphatidylserine synthesis in Jurkat T lymphocytes by K+ channel antagonists

1990 • 14 citations

Effect of K+ channel blockers on anti-immunoglobulin-induced murine B cell proliferation.

1988 • 12 citations

Interactive effects of Na and K in killing by human natural killer cells

1989 • 10 citations

Chapter 7 Cytosolic Calcium Changes during T- and B-Lymphocyte Activation: Biological Consequences and Significance

1990 • 8 citations

Role of K⁺Ion Channels in Lymphokine-Activated Killer (LAK) Cell Lytic Function

1989 • 7 citations

Chapter 5 Monovalent Ion Transport and Membrane Potential Changes during Leukocyte Activation: Lymphocytes

1990 • 6 citations

Chapter 19 Activation of Lymphocytes by Lymphokines

1990 • 5 citations

A transient acidification linked to intracellular Ca2 in anti‐μ‐stimulated human B‐lymphocytes

1990 • 3 citations

Chapter 9 Role of Intracellular pH in Lymphocyte Activation

1990 • 3 citations

Chapter 17 Induction of Protein Phosphorylation during Leukocyte Activation

1990 • 3 citations

Chapter 21 Portooncogene Expression following Lymphocyte Activation

1990 • 1 citations