Molecular Aspects of B-Lymphocyte Activation

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

Redistribution and Pinocytosis of Lymphocyte Surface Immunoglobulin Molecules Induced by Anti-Immunoglobulin Antibody

1971 • 1,093 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

1985 • 833 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

1985 • 679 citations

The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation

1971 • 677 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Bacterial Endotoxins and Host Immune Responses

1980 • 629 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

Replacement of T-Cell Function by a T-Cell Product

1972 • 537 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Membrane and Cytoplasmic Changes in B Lymphocytes Induced by Ligand-Surface Immunoglobulin Interaction

1976 • 383 citations

Direct Polyclonal Activation of Human B Lymphocytes by the Acquired Immune Deficiency Syndrome Virus

1986 • 374 citations

GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE

1972 • 349 citations

Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2)

1985 • 343 citations

Role of coated vesicles, microfilaments, and calmodulin in receptor-mediated endocytosis by cultured B lymphoblastoid cells.

1980 • 315 citations

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules.

1983 • 312 citations

Clonal growth and maturation to immunoglobulin secretion in vitro of every growth-inducible B lymphocyte

1977 • 309 citations

The CBA/N Mouse Strain: An Experimental Model Illustration the Influence of the X-Chromosome on Immunity

1982 • 305 citations

Complement Ligand-Receptor Interactions that Mediate Biological Responses

1983 • 294 citations

Interleukin-induced increase in Ia expression by normal mouse B cells.

1984 • 293 citations

Is There Evidence for a Non-Antigen Specific Diffusable Chemical Mediator from the Thymus-Derived Cell in the Initiation of the Immune Response?**Supported by U. S. Public Health Service Research Grant AI-08795-03 and American Cancer Society Research Grant E-395-D.

1971 • 276 citations

The specific direct interaction of helper T cells and antigen-presenting B cells.

1986 • 246 citations

Growth control of activated, synchronized murine B cells by the C3d fragment of human complement

1985 • 238 citations

Interaction of peptide antigens and class II major histocompatibility complex antigens

1986 • 221 citations

Capping and the Cytoskeleton

1984 • 215 citations

Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted

1981 • 207 citations

Immortalized B lymphocytes produce B-cell growth factor

1984 • 204 citations

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.

1983 • 204 citations

Role of γ-interferon in antibody-producing responses

1984 • 203 citations

Antigen presentation by normal B cells, B cell tumors, and macrophages: functional and biochemical comparison.

1982 • 199 citations

Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors.

1985 • 198 citations

Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.

1985 • 197 citations

Neuroleukin: A Lymphokine Product of Lectin-Stimulated T Cells

1986 • 195 citations

Fc-dependent inhibition of mouse B cell activation by whole anti-mu antibodies.

1983 • 187 citations

The activation of protein kinase C by biologically active lipid moieties of lipopolysaccharide.

1984 • 180 citations

B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis.

1984 • 180 citations

Actin and tubulin co-cap with surface immunoglobulins in mouse B lymphocytes

1977 • 177 citations

Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin.

1981 • 176 citations

Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes.

1985 • 154 citations

Induction of Human Interleukin-l by Toxic-Shock-Syndrome Toxin-1

1985 • 138 citations

Interferon-gamma suppresses B cell stimulation factor (BSF-1) induction of class II MHC determinants on B cells.

1986 • 138 citations

Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes.

1986 • 136 citations

B Lymphocyte: Activation by Insoluble Anti-Immunoglobulin: Induction of Immunoglobulin Secretion by a T Cell-Dependent Soluble Factor

1979 • 128 citations

Soluble factor requirements for the autostimulatory growth of B lymphoblasts immortalized by Epstein-Barr virus.

1984 • 127 citations

Redistribution of myosin accompanying capping of surface Ig.

1977 • 125 citations

Dissociation of two signals required for activation of resting B cells.

1982 • 123 citations

Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.

1985 • 119 citations

Biosynthesis and Regulation of Immunoglobulins

1983 • 119 citations

Factors Controlling the B-Cell Cycle

1986 • 116 citations

Redistribution of fodrin (a component of the cortical cytoplasm) accompanying capping of cell surface molecules.

1983 • 109 citations

Linkage between surface immunoglobulin and cytoskeleton of B lymphocytes may involve Gc protein

1983 • 106 citations

Development of a human T-T cell hybridoma secreting B cell growth factor.

1983 • 104 citations

Activation of murine B lymphocytes. III. Stimulation of B lymphocyte clonal growth with lipopolysaccharide and dextran sulfate.

1981 • 100 citations

Involvement of spectrin in cell-surface receptor capping in lymphocytes.

1983 • 97 citations

Requirement for macrophages or for macrophage‐ or T cell‐derived factors in the mitogenic stimulation of murine B lymphocytes by lipopolysaccharides

1983 • 93 citations

Calmodulin localization during capping and receptor-mediated endocytosis

1981 • 90 citations

Purification to homogeneity of a high molecular weight human B cell growth factor; demonstration of specific binding to activated B cells; and development of a monoclonal antibody to the factor.

1985 • 88 citations

Biochemical separation of a human B cell mitogenic factor.

1982 • 84 citations

Molecular events in B cell activation. I. Signals required to stimulate G0 to G1 transition of resting B lymphocytes.

1985 • 80 citations

The action of human C3 in soluble or cross‐linked form with resting and activated murine B lymphocytes

1985 • 79 citations

Actin may be present on the lymphocyte surface.

1978 • 72 citations

Specific cellular stimulation in the primary immune response: experimental test of a quantized model.

1982 • 70 citations

Interleukin 4 (B-cell growth factor II/eosinophil differentiation factor) is a mitogen and differentiation factor for preactivated murine B lymphocytes.

1986 • 70 citations

Regulation of antibody response in vitro. IV. Heavy chain antigenic determinants on hapten-specific memory cells.

1972 • 68 citations

Anti-immunoglobulin and phorbol ester induce phosphorylation of proteins associated with the plasma membrane and cytoskeleton in murine B lymphocytes.

1986 • 67 citations

Gc (vitamin D binding protein) binds to cytoplasm of all human lymphocytes and is expressed on B-cell membranes

1984 • 67 citations

Phorbol myristate acetate inhibits anti-IgM-mediated signaling in resting B cells.

1986 • 58 citations

A lymphoma plasma membrane-associated protein with ankyrin-like properties.

1986 • 58 citations

Anti-immunoglobulin augments the B-cell antigen-presentation function independently of internalization of receptor-antigen complex.

1985 • 56 citations

B cell-derived BCGF functions as autocrine growth factor(s) in normal and transformed B lymphocytes.

1986 • 53 citations

Production of B cell growth factor by normal human B cells.

1986 • 51 citations

Participation of calmodulin in immunoglobulin capping.

1982 • 50 citations

Activation of antigen-enriched B cells. II. Role of linked recognition in B cell proliferation to thymus-dependent antigens.

1983 • 48 citations

Activation and proliferation signals in mouse B cells. III. Intact (IGG) anti-immunoglobulin antibodies activate B cells but inhibit induction of DNA synthesis.

1984 • 48 citations

Perturbation of the human T-cell antigen receptor-T3 complex leads to the production of inositol tetrakisphosphate: evidence for conversion from inositol trisphosphate.

1986 • 46 citations

Cross-linking membrane IgM induces production of inositol trisphosphate and inositol tetrakisphosphate in WEHI-231 B lymphoma cells.

1987 • 41 citations

Capacity of B cells to function as stimulators of a primary mixed leukocyte reaction.

1986 • 41 citations

Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line.

1985 • 39 citations

Induction of antigen-specific proliferation in affinity-purified small B lymphocytes: requirement for BSF-1 by type 2 but not type 1 thymus-independent antigens.

1986 • 34 citations

Effects of Anti‐immunoglobulin Sera on B Lymphocyte Functions

1978 • 33 citations

The glycoprotein isolated from vesicular stomatitis virus is mitogenic for mouse B lymphocytes.

1981 • 32 citations

Constitutive production by the WEHI-3 cell line of B cell growth and differentiation factor that co-purifies with interleukin 1.

1983 • 32 citations

Polyclonal B cell stimulation and interleukin 1 induction by the mucoid exopolysaccharide of Pseudomonas aeruginosa associated with cystic fibrosis.

1985 • 30 citations

Immunoglobulin Heavy Chain Switching in Cultured I.29 Murine B Lymphoma Cells: Commitment to an IgA or IgE Switch

1984 • 28 citations

Internalized membrane immunoglobulin meets intracytoplasmic DR antigen in human B lymphoblastoid cells

1983 • 27 citations

A B cell growth factor-like activity is secreted by cloned, neoplastic B cells.

1984 • 26 citations

Relation between actin-associated proteins and membrane immunoglobulin in B-cells

1982 • 26 citations

The role of prostaglandins in endotoxic activities

1982 • 24 citations