Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2^Val-19-activated phenotypes

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

The neurofibromatosis type 1 gene encodes a protein related to GAP

1990 • 1,099 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1990 • 834 citations

Neurofibromatosis, Phenotype, Natural History, and Pathogenesis

1992 • 789 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

Somatic mutations in the neurofibromatosis 1 gene in human tumors

1992 • 399 citations

cDNA cloning of the type 1 neurofibromatosis gene: Complete sequence of the NF1 gene product

1991 • 391 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway

1990 • 193 citations

A Conserved Alternative Splice in the von Recklinghausen Neurofibromatosis (NF1) Gene Produces Two Neurofibromin Isoforms, Both of Which Have GTPase-Activating Protein Activity

1993 • 159 citations

Differential expression of two types of the neurofibromatosis type 1 (NF1) gene transcripts related to neuronal differentiation.

1991 • 119 citations

IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein.

1991 • 111 citations

Neurofibromatosis: Phenotype, Natural History and Pathogenesis

1987 • 98 citations

Ras interaction with the GTPase‐activating protein (GAP)

1989 • 87 citations

sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.

1991 • 77 citations

Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis.

1993 • 58 citations

Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue.

1992 • 54 citations

Interactions between adenylate cyclase and the yeast GTPase-activating protein IRA1.

1991 • 48 citations

Complete Human NF1 cDNA Sequence: Two Alternatively Spliced mRNAs and Absence of Expression in a Neuroblastoma Line

1992 • 36 citations

IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase protein

1991 • 35 citations

Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.

1993 • 25 citations