The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid.

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

1990 • 1,471 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

1990 • 1,107 citations

The neurofibromatosis type 1 gene encodes a protein related to GAP

1990 • 1,099 citations

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus

1990 • 1,085 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1990 • 834 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins

1984 • 471 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein

1990 • 333 citations

Cellular ras activity and phospholipid metabolism

1988 • 331 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

ras and GAP—Who's controlling whom?

1990 • 185 citations

Suppression of c-ras transformation by GTPase-activating protein

1990 • 166 citations

A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.

1989 • 161 citations

IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein.

1991 • 111 citations

The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures.

1991 • 86 citations

Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/“effector” domain

1991 • 83 citations

Serum stimulation of NIH 3T3 cells induces the production of lipids able to inhibit GTPase-activating protein activity.

1990 • 66 citations

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

1989 • 66 citations

Ras GTPase-activating protein physically associates with mitogenically active phospholipids.

1991 • 56 citations

Critical Role of Cellular ras Proteins in Proliferative Signal Transduction

1988 • 31 citations

Inhibition by Phospholipids of the Interaction between R-ras, Rho, and Their GTPase-Activating Proteins

1989 • 15 citations

Serum Stimulation of NIH 3T3 Cells Induces the Production of Lipids Able To Inhibit GTPase-Activating Protein Activity

1990 • 9 citations

Ras GTPase-Activating Protein Physically Associates with Mitogenically Active Phospholipids

1991 • 9 citations