An unstable beta 2-microglobulin: major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide.

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Protein folding in the cell

1992 • 4,138 citations

Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis

1978 • 1,954 citations

Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion

1976 • 1,926 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

1986 • 547 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro

1990 • 418 citations

Presentation of viral antigen controlled by a gene in the major histocompatibility complex

1990 • 381 citations

MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding

1994 • 356 citations

Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90)

1994 • 351 citations

Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

1989 • 329 citations

The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit.

1987 • 320 citations

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation

1989 • 317 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.

1991 • 304 citations

Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

1992 • 259 citations

Retention of Unassembled Components of Integral Membrane Proteins by Calnexin

1994 • 243 citations

Peptide-induced conformational change of the class I heavy chain

1991 • 221 citations

Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin)

1993 • 203 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

Role of beta2-microglobulin in the intracellular transport and surface expression of murine class I histocompatibility molecules

1989 • 153 citations

Excess β2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules

1991 • 129 citations

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

1992 • 125 citations

Intracellular transport of class I MHC molecules in antigen processing mutant cell lines.

1993 • 116 citations

Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum.

1994 • 106 citations

Peptide-induced stabilization and intracellular localization of empty HLA class I complexes.

1992 • 91 citations

Rescue of Daudi cell HLA expression by transfection of the mouse beta 2-microglobulin gene.

1988 • 79 citations

The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene.

1992 • 74 citations

A method to quantify binding of unlabeled peptides to class I MHC molecules and detect their allele specificity

1993 • 68 citations

Peptide binding to HLA-A2 and HLA-B27 isolated from Escherichia coli. Reconstitution of HLA-A2 and HLA-B27 heavy chain/beta 2-microglobulin complexes requires specific peptides.

1992 • 46 citations

Class I molecules retained in the endoplasmic reticulum bind antigenic peptides.

1993 • 31 citations

Short peptides assist the folding of free class I heavy chains in solution

1992 • 19 citations