α‐Synuclein and Polyunsaturated Fatty Acids Promote Clathrin‐Mediated Endocytosis and Synaptic Vesicle Recycling

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

α-Synuclein Locus Triplication Causes Parkinson's Disease

2003 • 4,187 citations

Regulated portals of entry into the cell

2003 • 3,642 citations

THE SYNAPTIC VESICLE CYCLE

2004 • 2,413 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1988 • 1,518 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models

2006 • 1,328 citations

The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1995 • 1,266 citations

Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

2002 • 1,152 citations

Identification of two distinct synucleins from human brain

1994 • 1,031 citations

Causal relation between α-synuclein locus duplication as a cause of familial Parkinson's disease

2004 • 1,002 citations

α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration

2005 • 930 citations

Structure and Dynamics of Micelle-bound Human α-Synuclein

2004 • 884 citations

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

2000 • 830 citations

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch

1995 • 826 citations

Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein

2002 • 817 citations

Optical Analysis of Synaptic Vesicle Recycling at the Frog Neuromuscular Junction

1992 • 766 citations

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1998 • 756 citations

Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons

2000 • 724 citations

Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr α‐synuclein mutation

2001 • 593 citations

Protein structure and function

2004 • 575 citations

The Formation of Highly Soluble Oligomers of α-Synuclein Is Regulated by Fatty Acids and Enhanced in Parkinson's Disease

2003 • 541 citations

Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology

2006 • 514 citations

Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation

1998 • 510 citations

A Broken α-Helix in Folded α-Synuclein

2003 • 509 citations

The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

2007 • 506 citations

Lipid Rafts Mediate the Synaptic Localization of α-Synuclein

2004 • 493 citations

Assembly of New Individual Excitatory Synapses

2000 • 490 citations

Imaging exocytosis and endocytosis

1996 • 451 citations

Synucleins in synaptic plasticity and neurodegenerative disorders

1999 • 430 citations

Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein α-Synuclein

2002 • 429 citations

Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids

2000 • 427 citations

Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

2004 • 406 citations

α-Synuclein Overexpression in PC12 and Chromaffin Cells Impairs Catecholamine Release by Interfering with a Late Step in Exocytosis

2006 • 404 citations

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease

2007 • 386 citations

MONITORING SECRETORY MEMBRANE WITH FM1-43 FLUORESCENCE

1999 • 368 citations

Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3

2006 • 336 citations

C<scp>ELL</scp>B<scp>IOLOGY OF THE</scp>P<scp>RESYNAPTIC</scp>T<scp>ERMINAL</scp>

2003 • 327 citations

Chronic Dietary α-Linolenic Acid Deficiency Alters Dopaminergic and Serotoninergic Neurotransmission in Rats ,

1994 • 318 citations

The Association of α-Synuclein with Membranes Affects Bilayer Structure, Stability, and Fibril Formation

2003 • 316 citations

α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

2001 • 310 citations

SNARE Protein Structure and Function

2003 • 305 citations

Lipid Binding Inhibits α-Synuclein Fibril Formation

2003 • 298 citations

Dietary Fish Oil Affects Monoaminergic Neurotransmission and Behavior in Rats

1998 • 286 citations

Mutation E46K increases phospholipid binding and assembly into filaments of human α‐synuclein

2004 • 274 citations

Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins

2001 • 274 citations

Effect of Clathrin Heavy Chain- and α-Adaptin-specific Small Inhibitory RNAs on Endocytic Accessory Proteins and Receptor Trafficking in HeLa Cells

2003 • 261 citations

Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice.

2001 • 257 citations

Membrane Association and Protein Conformation of α-Synuclein in Intact Neurons

2000 • 239 citations

Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion

1991 • 213 citations

An Early Stage of Membrane Fusion Mediated by the Low pH Conformation of Influenza Hemagglutinin Depends upon Membrane Lipids

1997 • 210 citations

Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies

2003 • 172 citations

A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin

1992 • 168 citations

Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex

2000 • 164 citations

Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor.

1993 • 140 citations

Helix periodicity, topology, and dynamics of membrane‐associated α‐Synuclein

2005 • 139 citations

Phosphoinositide regulation of clathrin-mediated endocytosis

2005 • 129 citations

Age-related changes in phospholipid fatty acid composition and monoaminergic neurotransmission in the hippocampus of rats fed a balanced or an n-3 polyunsaturated fatty acid-deficient diet

1997 • 127 citations

The human NACP/α-synuclein gene: chromosome assignment to 4q21.3–q22 and TaqI RFLP analysis

1995 • 118 citations

Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice

2002 • 110 citations

α-Synuclein Gene Deletion Decreases Brain Palmitate Uptake and Alters the Palmitate Metabolism in the Absence of α-Synuclein Palmitate Binding

2005 • 103 citations

Fatty acid incorporation is decreased in astrocytes cultured from α‐synuclein gene‐ablated mice

2005 • 103 citations

Brain neutral lipids mass is increased in α‐synuclein gene‐ablated mice

2007 • 102 citations

Phosphoinositide regulation of clathrin-mediated endocytosis

2005 • 101 citations

Presynaptic imaging techniques

2001 • 92 citations

Acyl-CoA Synthetase Activity Links Wild-Type but Not Mutant α-Synuclein to Brain Arachidonate Metabolism

2006 • 82 citations

α‐Synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids

2007 • 75 citations

The efficiency of the synaptic vesicle cycle at central nervous system synapses

2006 • 71 citations

Structural intermediates in influenza haemagglutinin-mediated fusion

1999 • 70 citations

Cycling of Synaptic Vesicles: How Far? How Fast!

2001 • 65 citations

Signaling and Endocytosis: A Team Effort for Cell Migration

2005 • 58 citations

Interactions between fatty acids and α-synuclein

2006 • 55 citations

A pre-synaptic to-do list for coupling exocytosis to endocytosis

2006 • 49 citations

Cycling of Synaptic Vesicles: How Far? How Fast!

2004 • 33 citations

Polyunsaturated fatty acids and neurotransmission in Caenorhabditis elegans

2006 • 29 citations

Addition of Triglycerides with Arachidonic Acid or Docosahexaenoic Acid to Infant Formula Has Tissue- and Lipid Class–Specific Effects on Fatty Acids and Hepatic Desaturase Activities in Formula-Fed Piglets

1998 • 29 citations

n‐3 polyunsaturated fatty acid deficiency and dopamine metabolism in the rat frontal cortex

1999 • 26 citations

Single-molecule live-cell imaging of clathrin-based endocytosis.

2005 • 17 citations