Mutation E46K increases phospholipid binding and assembly into filaments of human α‐synuclein

Staging of brain pathology related to sporadic Parkinson’s disease

2002 • 9,557 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

α-Synuclein Locus Triplication Causes Parkinson's Disease

2003 • 4,187 citations

α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

1998 • 2,898 citations

The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

2003 • 2,591 citations

Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

1985 • 2,037 citations

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1998 • 1,546 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

2000 • 1,497 citations

NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

1996 • 1,480 citations

Small-volume extrusion apparatus for preparation of large, unilamellar vesicles

1991 • 1,461 citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

1998 • 1,460 citations

Neuropathology of Parkinsonʼs Disease

1996 • 1,457 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

Alpha-synuclein and neurodegenerative diseases

2001 • 1,339 citations

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T

1989 • 1,133 citations

Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. Wright

2001 • 1,048 citations

Identification of two distinct synucleins from human brain

1994 • 1,031 citations

Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

1998 • 949 citations

Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

2003 • 790 citations

Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation

2000 • 714 citations

Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation

1999 • 695 citations

α-Synuclein Fibrillogenesis Is Nucleation-dependent

1999 • 686 citations

Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease

2001 • 675 citations

Comparison of kindreds with parkinsonism and α‐synuclein genomic multiplications

2004 • 669 citations

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

1998 • 647 citations

α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

1998 • 599 citations

α-Synuclein Membrane Interactions and Lipid Specificity

2000 • 571 citations

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

1999 • 510 citations

Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation

1998 • 510 citations

A Broken α-Helix in Folded α-Synuclein

2003 • 509 citations

Lipid Rafts Mediate the Synaptic Localization of α-Synuclein

2004 • 493 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Effect of Familial Parkinson's Disease Point Mutations A30P and A53T on the Structural Properties, Aggregation, and Fibrillation of Human α-Synuclein

2001 • 486 citations

Membrane-bound α-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form

2002 • 444 citations

Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein α-Synuclein

2002 • 429 citations

Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids

2000 • 427 citations

A Structural and Functional Role for 11-mer Repeats in α-Synuclein and Other Exchangeable Lipid Binding Proteins

2003 • 418 citations

Synthetic filaments assembled from C‐terminally truncated α‐synuclein

1998 • 408 citations

Structure of membrane-bound α-synuclein studied by site-directed spin labeling

2004 • 343 citations

Structural Organization of α-Synuclein Fibrils Studied by Site-directed Spin Labeling

2003 • 325 citations

The Association of α-Synuclein with Membranes Affects Bilayer Structure, Stability, and Fibril Formation

2003 • 316 citations

α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

2001 • 310 citations

Straight and paired helical filaments in Alzheimer disease have a common structural unit.

1991 • 310 citations

Lipid Binding Inhibits α-Synuclein Fibril Formation

2003 • 298 citations

Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins

2001 • 274 citations

Effects of the mutations Ala³⁰ to Pro and Ala⁵³ to Thr on the physical and morphological properties of α‐synuclein protein implicated in Parkinson's disease

1998 • 263 citations

α-Synuclein Has a High Affinity for Packing Defects in a Bilayer Membrane

2004 • 232 citations

Defective membrane interactions of familial Parkinson’s disease mutant A30P α-synuclein 1 1Edited by I. B. Holland

2002 • 217 citations

Abnormal Tau-Containing Filaments in Neurodegenerative Diseases

2000 • 177 citations

Membrane Binding and Self-Association of α-Synucleins

2001 • 166 citations

Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain

2000 • 152 citations

Effects of Parkinson's Disease-Linked Mutations on the Structure of Lipid-Associated α-Synuclein

2004 • 139 citations

Synaptotagmin Interaction with the Syntaxin/SNAP-25 Dimer Is Mediated by an Evolutionarily Conserved Motif and Is Sensitive to Inositol Hexakisphosphate

2004 • 128 citations

α‐Synuclein–synaptosomal membrane interactions

2004 • 81 citations

Asymmetry of lipid organization in cholinergic synaptic vesicle membranes

1983 • 78 citations

Gas-liquid chromatographic study and estimation of several urinary aromatic acids

1966 • 56 citations

α-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates

2003 • 44 citations