Cell Type‐specific Effects of the Neural Adhesion Molecules L1 and N‐CAM on Diverse Second Messenger Systems

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain

1959 • 2,294 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones.

1987 • 1,290 citations

Neural Cell Adhesion Molecule: Structure, Immunoglobulin-Like Domains, Cell Surface Modulation, and Alternative RNA Splicing

1987 • 1,134 citations

Classes of Calcium Channels in Vertebrate Cells

1989 • 1,082 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion.

1984 • 739 citations

G protein involvement in receptor-effector coupling.

1988 • 618 citations

Differential inhibition of neurone–neurone, neurone–astrocyte and astrocyte–astrocyte adhesion by L1, L2 and N-CAM antibodies

1985 • 497 citations

L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum

1983 • 482 citations

G Proteins in Signal Transduction

1990 • 479 citations

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

1983 • 473 citations

An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.

1987 • 464 citations

L1-mediated axon outgrowth occurs via a homophilic binding mechanism

1989 • 423 citations

Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels

1991 • 394 citations

Neural cell adhesion molecules influence second messenger systems

1989 • 387 citations

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

1988 • 359 citations

Genetic analysis of a drosophila neural cell adhesion molecule: Interaction of fasciclin I and abelson tyrosine kinase mutations

1990 • 340 citations

The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions.

1990 • 305 citations

The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions

1987 • 303 citations

Studies of adhesion molecules mediating interactions between cells of peripheral nervous system indicate a major role for L1 in mediating sensory neuron growth on Schwann cells in culture.

1988 • 288 citations

Neuronal cell–cell adhesion depends on interactions of N-CAM with heparin-like molecules

1986 • 270 citations

Inositol Lipids and Signal Transduction in the Nervous System: An Update

1992 • 260 citations

Increased brain myo-inositol 1-phosphate in lithium-treated rats

1976 • 252 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes

1992 • 197 citations

Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain.

1989 • 196 citations

Selective expression of the 180-kD component of the neural cell adhesion molecule N-CAM during development.

1985 • 196 citations

Immunoelectron‐microscopic localization of the 180 kD component of the neural cell adhesion molecule N‐CAM in postsynaptic membranes

1989 • 195 citations

Expression of Thy-1, H-2 and NS-4 cell surface antigens and tetanus toxin receptors in early postnatal and adult mouse cerebellum

1981 • 177 citations

Functional cooperation between the neural adhesion molecules L1 and N-CAM is carbohydrate dependent.

1990 • 174 citations

Studies on the transmembrane disposition of the neural cell adhesion molecule N-CAM. A monoclonal antibody recognizing a cytoplasmic domain and evidence for the presence of phosphoserine residues

1984 • 158 citations

Monoclonal antibody against cell surface glycoprotein of neurons

1981 • 151 citations

Identification of a heparin binding domain of the neural cell adhesion molecule N-CAM using synthetic peptides

1989 • 151 citations

Ionic responses and growth stimulation induced by nerve growth factor and epidermal growth factor in rat pheochromocytoma (PC12) cells.

1983 • 150 citations

Protein kinase C is involved in laminin stimulation of neurite outgrowth

1989 • 140 citations

Recombinant peripheral myelin protein P_o confers both adhesion and neurite outgrowth‐promoting properties

1990 • 133 citations

Guanine nucleotides stimulate production of inositol trisphosphate in rat cortical membranes

1985 • 125 citations

Astrocyte-derived TGF-beta 2 and NGF differentially regulate neural recognition molecule expression by cultured astrocytes.

1991 • 123 citations

Cultivation of mouse cerebellar cells in serum free, hormonally defined media: Survival of neurons

1982 • 121 citations

Different extracellular domains of the neural cell adhesion molecule (N-CAM) are involved in different functions.

1992 • 117 citations

Molecular heterogeneity and structural evolution during cerebellar ontogeny detected by monoclonal antibody of the mouse cell surface antigen BSP-2

1983 • 117 citations

Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms.

1990 • 116 citations

Neural Surface Antigens during Nervous System Development

1983 • 113 citations

Expression of neural cell adhesion molecule L1 during development, in neurological mutants and in the peripheral nervous system

1984 • 113 citations

Isolation of mouse N-CAM-related cDNA: detection and cloning using monoclonal antibodies.

1985 • 108 citations

Comparison of two cell surface molecules involved in neural cell adhesion.

1984 • 90 citations

Transfection of neonatal rat Schwann cells with SV-40 large T antigen gene under control of the metallothionein promoter.

1987 • 73 citations

Experimental modification of postnatal cerebellar granule cell migration in vitro

1986 • 69 citations

A Protein Kinase Activity Is Associated with and Specifically Phosphorylates the Neural Cell Adhesion Molecule LI

1989 • 68 citations

Both protein kinase C and calcium mediate activation of the Na⁺/H⁺ antiporter in Chinese hamster embryo fibroblasts

1987 • 57 citations

Adhesion of neural cells to extracellular matrix constituents. Involvement of glycosaminoglycans and cell adhesion molecules

1988 • 54 citations

Molecular Association of the Neural Adhesion Molecules L1 and N‐CAM in the Surface Membrane of Neuroblastoma Cells is Shown by Chemical Cross‐linking

1991 • 29 citations

Dual loading of the fluorescent indicator fura-2 and 2,7-biscarboxyethyl-5(6)-carboxyfluorescein (BCECF) in isolated myocytes

1989 • 27 citations

Lateral Mobility of the Cell Adhesion Molecule L1 Within the Surface Membrane of Morphologically Undifferentiated and Differentiated Neuroblastoma Cells

1990 • 17 citations