Different extracellular domains of the neural cell adhesion molecule (N-CAM) are involved in different functions.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

1972 • 1,456 citations

Vectors for selective expression of cloned DNAs by T7 RNA polymerase

1987 • 1,449 citations

Neural Cell Adhesion Molecule: Structure, Immunoglobulin-Like Domains, Cell Surface Modulation, and Alternative RNA Splicing

1987 • 1,134 citations

Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation

1991 • 796 citations

Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion.

1984 • 739 citations

Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1

1984 • 723 citations

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

CELL ADHESION MOLECULES: Implications for a Molecular Histology

1991 • 707 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin

1988 • 653 citations

Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.

1983 • 635 citations

The J1 glycoprotein—a novel nervous system cell adhesion molecule of the L2/HNK-1 family

1985 • 590 citations

The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity

1990 • 569 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

Differential inhibition of neurone–neurone, neurone–astrocyte and astrocyte–astrocyte adhesion by L1, L2 and N-CAM antibodies

1985 • 497 citations

Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function.

1984 • 465 citations

An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.

1987 • 464 citations

Protein G: a powerful tool for binding and detection of monoclonal and polyclonal antibodies.

1985 • 453 citations

Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos.

1984 • 429 citations

L1-mediated axon outgrowth occurs via a homophilic binding mechanism

1989 • 423 citations

Neural cell adhesion molecules influence second messenger systems

1989 • 387 citations

Renaturation, Purification and Characterization of Recombinant Fab-Fragments Produced in Escherichia coli

1991 • 385 citations

The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions.

1988 • 373 citations

Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and myelin-associated glycoprotein) in regenerating adult mouse sciatic nerve.

1988 • 364 citations

Adult and embryonic mouse neural cell adhesion molecules have different binding properties

1983 • 350 citations

Pathways and mechanisms of avian trunk neural crest cell migration and localization

1982 • 336 citations

Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscle.

1986 • 307 citations

The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions.

1990 • 305 citations

The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions

1987 • 303 citations

Studies of adhesion molecules mediating interactions between cells of peripheral nervous system indicate a major role for L1 in mediating sensory neuron growth on Schwann cells in culture.

1988 • 288 citations

J1/tenascin in substrate-bound and soluble form displays contrary effects on neurite outgrowth.

1991 • 276 citations

The mouse neuronal cell surface protein F3: a phosphatidylinositol-anchored member of the immunoglobulin superfamily related to chicken contactin.

1989 • 267 citations

Neurite outgrowth patterns in cerebellar microexplant cultures are affected by antibodies to the cell surface glycoprotein L1

1986 • 264 citations

Differentiation state-dependent surface mobilities of two forms of the neural cell adhesion molecule

1986 • 262 citations

A threshold effect of the major isoforms of NCAM on neurite outgrowth

1990 • 260 citations

Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system

1988 • 258 citations

Phosphatidylinositol is involved in the membrane attachment of NCAM-120, the smallest component of the neural cell adhesion molecule.

1986 • 232 citations

Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a Mr 79,000 polypeptide without a membrane-spanning region.

1987 • 231 citations

Neural cell recognition molecule F11: Homology with fibronectin type III and immunoglobulin type C domains

1989 • 222 citations

A heparin-binding domain from N-CAM is involved in neural cell-substratum adhesion.

1986 • 216 citations

Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes

1992 • 197 citations

Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain.

1989 • 196 citations

Selective expression of the 180-kD component of the neural cell adhesion molecule N-CAM during development.

1985 • 196 citations

Immunoelectron‐microscopic localization of the 180 kD component of the neural cell adhesion molecule N‐CAM in postsynaptic membranes

1989 • 195 citations

Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitro

1982 • 194 citations

Organization of the neural cell adhesion molecule (N-CAM) gene: alternative exon usage as the basis for different membrane-associated domains.

1987 • 193 citations

Expression sequences of cell adhesion molecules.

1985 • 193 citations

Molecular forms of N-CAM and its RNA in developing and denervated skeletal muscle.

1986 • 190 citations

Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules.

1991 • 190 citations

Recombinant myelin-associated glycoprotein confers neural adhesion and neurite outgrowth function

1989 • 190 citations

Expression of the neural cell adhesion molecules L1 and N-CAM and their common carbohydrate epitope L2/HNK-1 during development and after transection of the mouse sciatic nerve

1985 • 183 citations

Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs

1991 • 178 citations

Expression of Thy-1, H-2 and NS-4 cell surface antigens and tetanus toxin receptors in early postnatal and adult mouse cerebellum

1981 • 177 citations

Functional cooperation between the neural adhesion molecules L1 and N-CAM is carbohydrate dependent.

1990 • 174 citations

Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily.

1991 • 160 citations

Antibodies to a neural cell adhesion molecule disrupt histogenesis in cultured chick retinae

1980 • 160 citations

Studies on the transmembrane disposition of the neural cell adhesion molecule N-CAM. A monoclonal antibody recognizing a cytoplasmic domain and evidence for the presence of phosphoserine residues

1984 • 158 citations

Biosynthesis and membrane topography of the neural cell adhesion molecule L1.

1985 • 157 citations

Monoclonal antibody against cell surface glycoprotein of neurons

1981 • 151 citations

Identification of a heparin binding domain of the neural cell adhesion molecule N-CAM using synthetic peptides

1989 • 151 citations

Mutational analysis of the interaction between CD4 and class II MHC: Class II antigens contact CD4 on a surface opposite the gp120-binding site

1991 • 146 citations

Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouse.

1988 • 146 citations

Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)

1987 • 143 citations

Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment.

1988 • 135 citations

Recombinant peripheral myelin protein P_o confers both adhesion and neurite outgrowth‐promoting properties

1990 • 133 citations

Cultivation of mouse cerebellar cells in serum free, hormonally defined media: Survival of neurons

1982 • 121 citations

Induction of neural cell adhesion molecule (NCAM) in Xenopus embryos

1986 • 117 citations

Alteration of the retinotectal map in Xenopus by antibodies to neural cell adhesion molecules.

1984 • 117 citations

Molecular heterogeneity and structural evolution during cerebellar ontogeny detected by monoclonal antibody of the mouse cell surface antigen BSP-2

1983 • 117 citations

Effects of fasciculation on the outgrowth of neurites from spinal ganglia in culture.

1980 • 116 citations

The neural cell adhesion molecule L1 is distinct from the N-CAM related group of surface antigens BSP-2 and D2.

1984 • 115 citations

Neural Surface Antigens during Nervous System Development

1983 • 113 citations

Role of N-linked glycans in the interaction between the envelope glycoprotein of human immunodeficiency virus and its CD4 cellular receptor. Structural enzymatic analysis.

1989 • 113 citations

Isolation of mouse N-CAM-related cDNA: detection and cloning using monoclonal antibodies.

1985 • 108 citations

Neuronal process outgrowth of human sensory neurons on monolayers of cells transfected with cDNAs for five human N-CAM isoforms.

1989 • 96 citations

Topography of N-CAM structural and functional determinants. II. Placement of monoclonal antibody epitopes.

1986 • 90 citations

Comparison of two cell surface molecules involved in neural cell adhesion.

1984 • 90 citations

Characterization of binding properties of the myelin-associated glycoprotein to extracellular matrix constituents.

1987 • 83 citations

Mapping of three carbohydrate attachment sites in embryonic and adult forms of the neural cell adhesion molecule.

1984 • 79 citations

Release of the 120 kDa component of the mouse neural cell adhesion molecule N-CAM from cell surfaces by phosphatidylinositol-specific phospholipase C

1986 • 70 citations

Localization of the L2 monoclonal antibody binding site on chicken neural cell adhesion molecule (NCAM) and evidence for its role in NCAM-mediated cell adhesion

1987 • 68 citations

Neural cell adhesion molecule expression is regulated by Schwann cell-neuron interactions in culture.

1989 • 62 citations

Adhesion of neural cells to extracellular matrix constituents. Involvement of glycosaminoglycans and cell adhesion molecules

1988 • 54 citations

Small inhibitory cerebellar interneurons grow in a perpendicular orientation to granule cell neurites in culture

1989 • 32 citations

Molecular Association of the Neural Adhesion Molecules L1 and N‐CAM in the Surface Membrane of Neuroblastoma Cells is Shown by Chemical Cross‐linking

1991 • 29 citations

Synthesis and characterization of extended and deleted recombinant analogs of parathyroid hormone-(1-84): correlation of peptide structure with function

1990 • 24 citations

Lateral Mobility of the Cell Adhesion Molecule L1 Within the Surface Membrane of Morphologically Undifferentiated and Differentiated Neuroblastoma Cells

1990 • 17 citations

Accumulation of N‐CAM 180 at Contact Sites Between Neuroblastoma Cells and Latex Beads Coated with Extracellular Matrix Molecules

1990 • 10 citations