Identification of a Signal for Nuclear Targeting in Platelet-Derived-Growth-Factor-Related Molecules

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Sequence requirements for nuclear location of simian virus 40 large-T antigen

1984 • 1,278 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Nuclear envelope permeability

1975 • 808 citations

A polypeptide domain that specifies migration of nucleoplasmin into the nucleus

1982 • 556 citations

Protein Import into the Cell Nucleus

1986 • 544 citations

Movement of a karyophilic protein through the nuclear pores of oocytes.

1984 • 510 citations

Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores.

1987 • 510 citations

Synthetic peptides as nuclear localization signals

1986 • 472 citations

Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal

1986 • 394 citations

Targeting of E. coli β-galactosidase to the nucleus in yeast

1984 • 386 citations

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

1984 • 376 citations

Many Random Sequences Functionally Replace the Secretion Signal Sequence of Yeast Invertase

1987 • 375 citations

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

1983 • 352 citations

Nuclear location signals in polyoma virus large-T

1986 • 351 citations

Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis.

1983 • 293 citations

Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis

1985 • 286 citations

Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization.

1984 • 284 citations

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

1984 • 277 citations

Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells

1985 • 263 citations

Protein migration into nuclei. I. Frog oocyte nuclei in vivo accumulate microinjected histones, allow entry to small proteins, and exclude large proteins.

1975 • 262 citations

Expression of a Platelet-Derived Growth Factor-Like Protein in Simian Sarcoma Virus Transformed Cells

1983 • 246 citations

Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor.

1985 • 236 citations

Effect of heat shock on protein degradation in mammalian cells: involvement of the ubiquitin system.

1987 • 235 citations

Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus

1985 • 205 citations

Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus

1984 • 203 citations

Chromatin binding of epidermal growth factor, nerve growth factor, and platelet-derived growth factor in cells bearing the appropriate surface receptors.

1986 • 193 citations

Expression of a recombinant DNA gene coding for the vesicular stomatitis virus nucleocapsid protein

1983 • 170 citations

Blockade of autocrine stimulation in simian sarcoma virus-transformed cells reverses down-regulation of platelet-derived growth factor receptors.

1984 • 163 citations

Identification of a nuclear localization signal of a yeast ribosomal protein.

1985 • 162 citations

Nucleocytoplasmic exchange of macromolecules

1972 • 144 citations

The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.

1985 • 143 citations

Simian Sarcoma Virus—Transformed Cells Secrete a Mitogen Identical to Platelet-Derived Growth Factor

1984 • 137 citations

Nucleotide sequence of the tcml gene (ribosomal protein L3) of Saccharomyces cerevisiae

1983 • 126 citations

Human platelet-derived growth factor: radioimmunoassay and discovery of a specific plasma-binding protein.

1983 • 106 citations

Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor.

1985 • 97 citations

Nucleolar structure and ribosome biogenesis

1986 • 96 citations

Primary structure of chicken muscle pyruvate kinase mRNA.

1983 • 93 citations

The nuclear location signal

1985 • 92 citations

Nucleocytoplasmic movement of fluorescent tracers microinjected into living salivary gland cells.

1975 • 89 citations

Requirement for a Signal Sequence in Biological Expression of the v- sis Oncogene

1984 • 69 citations

Ultrastructural localization of a platelet-derived growth factor/v-sis-related protein(s) in cytoplasm and nucleus of simian sarcoma virus-transformed cells.

1987 • 63 citations

Deletions in the N-terminal coding region of the v-sis gene: determination of the minimal transforming region

1986 • 33 citations

Cell surface expression of membrane-anchored v-sis gene products: glycosylation is not required for cell surface transport.

1986 • 32 citations