Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a []GTPγS binding study

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

1996 • 1,143 citations

Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine

1996 • 1,047 citations

Molecular biology of 5-HT receptors

1994 • 679 citations

Drugs and the treatment of psychiatric disorders

1996 • 581 citations

5-HT1A receptor agonists: recent developments and controversial issues

1995 • 463 citations

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

Diversity and Selectivity of Receptor-G Protein Interaction

1996 • 365 citations

Negative symptoms: a path analytic approach to a double-blind, placebo- and haloperidol-controlled clinical trial with olanzapine

1997 • 302 citations

Serotonin receptors in cognitive behaviors

1997 • 299 citations

Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.

1995 • 299 citations

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

1989 • 273 citations

The classification of seven transmembrane receptors in recombinant expression systems.

1996 • 271 citations

Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands.

1994 • 249 citations

Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors

1997 • 235 citations

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.

1990 • 227 citations

Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation

1997 • 201 citations

NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)

1988 • 183 citations

The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes

1995 • 178 citations

[3H]WAY–100635 for 5–HT1A receptor autoradiography in human brain: a comparison with [3H]8–OH–DPAT and demonstration of increased binding in the frontal cortex in schizophrenia

1997 • 174 citations

Extrapyramidal Symptoms and Tolerability of Olanzapine Versus Haloperidol in the Acute Treatment of Schizophrenia

1997 • 171 citations

Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia

1991 • 169 citations

Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.

1995 • 164 citations

Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists.

1982 • 158 citations

Centrally acting hypotensive agents with affinity for 5‐HT_1A binding sites inhibit forskolin‐stimulated adenylate cyclase activity in calf hippocampus

1988 • 151 citations

Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture.

1988 • 150 citations

Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein .alpha.-subunits and lack of coupling to Gs.alpha.

1993 • 145 citations

Effects of atypical antipsychotic agents on social behavior in rodents

1993 • 126 citations

Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.

1995 • 118 citations

Evidence that antipsychotic drugs are inverse agonists at D₂ dopamine receptors

1997 • 116 citations

Clozapine is a partial agonist at cloned, human serotonin 5-HT1A receptors

1996 • 110 citations

Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase.

1991 • 106 citations

Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes.

1992 • 105 citations

Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.

1991 • 100 citations

An Open Trial of Buspirone Added to Neuroleptics in Schizophrenic Patients

1991 • 97 citations

Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats.

1996 • 95 citations

Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.

1991 • 89 citations

Electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5‐HT_1A agonists

1993 • 87 citations

Inhibition of the constitutive activity of human 5‐HT_1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635

1997 • 86 citations

The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro

1992 • 84 citations

Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1a receptors that are negatively coupled to adenylate cyclase in permanently transfected hela cells

1993 • 78 citations

Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists.

1994 • 77 citations

Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTPγS binding

1997 • 76 citations

Pre-clinical Pharmacology of Atypical Antipsychotic Drugs: A Selective Review

1996 • 74 citations

Dual couplings of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein

1991 • 72 citations

Further evidence for differential affinity states of the serotonin1A receptor in rat hippocampus

1992 • 70 citations

A Clinical Guide to Antipsychotic Drugs

1992 • 68 citations

Clozapine has sub-micromolar affinity for 5-HT1A receptors in human brain tissue

1992 • 64 citations

Transfection of human 5-hydroxytryptamine1A receptors in NIH-3T3 fibroblasts: effects of increasing receptor density on the coupling of 5-hydroxytryptamine1A receptors to adenylyl cyclase.

1992 • 63 citations

BMY 14802, a Sigma Receptor Ligand for the Treatment of Schizophrenia

1994 • 63 citations

The 5-HT1A antagonist, WAY 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset.

1996 • 63 citations

Pharmacological Characterisation of [³⁵S]-GTPγS Binding to Chinese Hamster Ovary Cell Membranes Stably Expressing Cloned Human 5-HT_1DReceptor Subtypes

1995 • 63 citations

Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs

1988 • 62 citations

Drug Treatment of Schizophrenia in the 1990s

1997 • 58 citations

Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells

1992 • 55 citations

High-level stable expression of recombinant 5-HT1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells

1992 • 54 citations

Clozapine inhibits serotoninergic transmission by an action at α1-adrenoceptors not at 5-HT1A receptors

1994 • 54 citations

S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist at presynaptic and postsynaptic sites respectively

1993 • 54 citations

[35S]Guanosine-5'-O-(3-thio)triphosphate binding as a measure of efficacy at human recombinant dopamine D4.4 receptors: actions of antiparkinsonian and antipsychotic agents.

1997 • 53 citations

S 15535 and WAY 100,635 antagonise 5-HT-stimulated [35S]GTPγS binding at cloned human 5-HT1A receptors

1996 • 47 citations

Binding of Typical and Atypical Antipsychotic Drugs to Multiple Neurotransmitter Receptors

1997 • 45 citations

Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese Hamster Ovary cells

1993 • 45 citations

S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors.

1992 • 44 citations

S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity.

1997 • 40 citations

The dopamine D3 receptor antagonist, (+)-S14297, blocks the cataleptic properties of haloperidol in rats

1997 • 39 citations

[3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe

1997 • 39 citations

5-HT1A receptors are not involved in clozapine's lack of cataleptogenic potential

1996 • 37 citations

Prevention by (±)‐8‐hydroxy‐2‐(di‐npropylamino)tetralin of both catalepsy and the rises in rat striatal dopamine metabolism caused by haloperidol

1996 • 33 citations

Augmentation with Buspirone: A Review

1995 • 32 citations

The 5-HT1A receptor antagonist (S)-UH-301 blocks the (R)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat

1994 • 31 citations

Potency of 5-hydroxytryptamine1a agonists to inhibit adenylyl cyclase activity is a function of affinity for the "low-affinity" state of [3H]8-hydroxy-N,N-dipropylaminotetralin ([3H]8-OH-DPAT) binding.

1993 • 30 citations

Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone.

1994 • 29 citations

The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists

1994 • 24 citations

The 5-HT 1A antagonist, WAY 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset

1996 • 21 citations

Pharmacological characterization of the 5-hydroxytryptamine-1A receptor-mediated activation of high-affinity GTP hydrolysis in rat hippocampal membranes.

1995 • 18 citations

Tiaspirone in Schizophrenia

1987 • 16 citations

A Controlled Clinical Trial of Tiaspirone in Schizophrenia

1987 • 12 citations

Evaluation of Butaclamol in Chronic Schizophrenic Patients

1977 • 11 citations

P-4-13 Comparative profiles of interaction of atypical antipsychotics at cloned human dopamine hD2, hD3 and hD4 receptors: S 16924 shows a marked preference for hD4 sites

1995 • 1 citations